Craniopharyngiomas: A Comprehensive Guide to Diagnosis, Treatment and Outcome is a comprehensive guide to the science, diagnosis and treatment of craniopharyngiomas, rare brain tumors that grow near the pituitary gland. Even though these tumors are generally benign, due to the location, prognosis was often bleak. This reference provides a resource for specialists requiring a comprehensive overview of this rare form of tumor, outlining new diagnostic, imaging and surgical techniques, including endoscopic endonasal cranial base surgery, which enable successful neurosurgical intervention. With a better prognosis, patients require multidisciplinary management from neurology, otolaryngology, radiation oncology, endocrinology, and neuropathology.

Key Features

  • The only comprehensive guide to the science, diagnosis and treatment of craniopharyngiomas
  • Includes multidisciplinary management from neurology, otolaryngology, radiation oncology, endocrinology, and neuropathology
  • Detailed coverage of the impacts of new diagnostic, imaging and neurosurgical techniques including endoscopic endonasal cranial base surgery


Practitioners and clinical researchers in the fields of neuroscience, neurology, neurooncology, neurosurgery, otolaryngology, radiation oncology, and neuropathology.

Table of Contents

  • Dedications
  • List of Contributors
  • Foreword
  • Preface
  • Section I. Introduction
    • Chapter 1. Introduction
      • Introduction
      • Epidemiology
      • Pathophysiology
      • History
      • Presentation and the Modern Disease Course
      • Conclusion
    • Chapter 2. Craniopharyngiomas: Anatomical Considerations
      • Introduction
      • Anatomy of the Cranial Base
      • Vascular Relationships
      • Cisternal, Neural, and Ventricular Anatomy
      • Anatomy of Surgical Approaches for Craniopharyngiomas
    • Chapter 3. Imaging of Craniopharyngiomas and Radiologic Differential Diagnosis
      • Introduction
      • Imaging – General Concepts
      • Location, Location, Location
      • Adamantinomatous Craniopharyngioma
      • Papillary Craniopharyngioma
      • Unusual Locations of Craniopharyngioma
      • Rathke Cleft Cyst
      • Radiologic Differential Diagnosis
      • Vascular Pedicle Nasoseptal Flap
      • Conclusion
    • Chapter 4. Craniopharyngioma: Embryology, Pathology, and Molecular Aspects
      • Definition and Embryogenesis
      • Pathology
      • Molecular Genetics
  • Section II. Medical Evaluation
    • Chapter 5. Craniopharyngioma: Neuroendocrine Evaluation and Management
      • Introduction
      • Prevalence of Neuroendocrine Dysfunction
      • Clinical Features and Findings
      • Diagnosis
      • Management
      • Summary – Future Directions
    • Chapter 6. Neuro-Ophthalmic Manifestations of Craniopharyngiomas
      • Introduction and Historical Background
      • Pathophysiology of The Visual Symptoms
      • Summary
  • Section III. Surgical Approaches
    • Chapter 7. Surgical Approaches: Introduction and Outcomes
      • Introduction
      • Outcomes
    • Chapter 8. Endoscopic Resection of Craniopharyngiomas
      • Intro


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© 2015
Academic Press
eBook ISBN:
Print ISBN:

About the editors

James Evans

Professor, Department of Neurological Surgery and Otolaryngology, Director, Cranial Base and Pituitary Surgery, Co-Director, Jefferson Center for Minimally Invasive Cranial Base Surgery, Thomas Jefferson University Hospital. Dr. Evans is a fellowship-trained cranial base surgeon, board-certified, and has been in practice for over ten years. He has held numerous prominent positions in national societies, is well-known in the field of cranial base surgery, and is an innovator in the field of endoscopic endonasal surgery. He is well-published and co-authored Clinical Manual of Trigeminal Neuralgia (CRC Press, 2007).

Affiliations and Expertise

Department of Neurological Surgery and Otolaryngology, Thomas Jefferson University, Philadelphia, PA, USA

Tyler Kenning

Assistant Professor of Neurosurgery, Albany Medical Center. Dr. Kenning is fellowship trained in surgery of pathology of the cranial base and specifically endoscopic endonasal surgery, Dr. Kenning heads the cranial base surgery program at a major academic center in Albany, NY. He has authored many peer-reviewed papers in neurosurgical and neuro-oncological journals as well as contributed several book chapters.

Affiliations and Expertise

Department of Neurosurgery, Albany Medical Center, Albany, NY, USA