Description

Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful.

Key Features

  • The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels.
  • Contributors are authoritative researchers who have produced important advances in the field.
  • The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject.


Readership

Scientists and researchers in biochemistry and molecular and cellular biology

Table of Contents

Series Page

Contributors

Preface

Previous Volumes in Series

Chapter One. Store-Operated Orai Channels: Structure and Function

1 Introduction

2 Identification of the Orai Proteins

3 STIM1 Is the ER Ca2 + Sensor for SOCE

4 Orai1 Is the Pore-Forming Subunit of the CRAC Channel

5 The CRAC Channel Is Essential for Lymphocyte Activation

6 Oligomerization and Redistribution of STIM1 to the ER–Plasma Membrane Junctions

7 Conformational Changes in STIM1

8 STIM1 Directly Binds to Orai1

9 Orai1 Domains Involved in STIM1 Binding

10 CRAC Channel Subunit Stoichiometry

11 How Many STIM Molecules Does It Take to Activate CRAC Channels?

12 Structural Basis of Selectivity and Permeation

13 STIM1 Regulates CRAC Channel Ion Selectivity

14 Regulation of CRAC Channels by Calcium

15 Conclusions

Acknowledgments

References

Chapter Two. STIM–ORAI Interactions That Control the CRAC Channel

1 Overview of STIM–ORAI Interactions

2 The C-terminal Region of the ORAI Channel

3 The N-terminal Region of the ORAI Channel

4 Conclusion

Acknowledgments

References

Chapter Three. Structure and Function of Endoplasmic Reticulum STIM Calcium Sensors

1 Introduction

2 STIM and Orai Domain Architectures

3 STIM1 and Orai1 in the Activation in SOCE

4 Human STIM1 and STIM2 EF–SAM Biophysical Features

5 Human STIM1 EF–SAM Structure

6 Human STIM2 EF–SAM Structure

7 Human STIM1 and STIM2 Cytosolic Domains

8 STIM Coupling to Orai

9 Concluding Remarks

Acknowledgments

References

Chapter Four. On the Stoichiometry of Resting and Activated CRAC Channels

1 The Stoichiometry of Orai1

2 The Stoichiometry of STIM1

3 Summary

Details

No. of pages:
298
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
Electronic ISBN:
9780124079380
Print ISBN:
9780124078703

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