Corticotrophin (ACTH) - 1st Edition - ISBN: 9780124472136, 9780323160124

Corticotrophin (ACTH)

1st Edition

Editors: Choh Hao Li
eBook ISBN: 9780323160124
Imprint: Academic Press
Published Date: 12th February 1987
Page Count: 212
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Description

Hormonal Proteins and Peptides: Corticotrophin (ACTH) is a collection of papers dealing with the chemistry and biology of adrenocorticotropic hormone (ACTH). One paper describes the structure-function studies made on ACTH, with reference to the steroidogenic activity of synthetic ACTH fragments and analogs. The paper also discusses the melanocyte-stimulating hormone (MSH) activity, as well as the behavioral effects among the extraadrenal properties of ACTH. Some problems related to ACTH receptors include the role of extracellular calcium and the characterization of ACTH receptors in fetal and adult human adrenocortical cells. Another paper describes ACTH synthesis in the pituitary and extrapituitary tissues. One paper analyzes the role of ACTH in the regulation process concerning the production of steroid hormones, particularly, on the generation of glucocorticoids. Glucocorticoids are the characteristic products of the zona fasciculata. Another paper shows that the steady-state level of ACTH synthesis and release are due to the effects of stimulatory factors such as CRF and inhibitory hormones (namely, the glucocorticoids on the corticotroph). The maintenance of responsiveness of ACTH-secreting cells (as a response to individual stress in humans) can be a manifestation of an inherent molecular characteristic. This collection will prove valuable to microbiologists, biotechnologists, and academicians connected with the biological sciences.

Table of Contents


Preface


1 ACTH: Structure—Function Relationship


I. Introduction


II. Structure of ACTH


III. Structure—Function Relationships


IV. Conclusions


References


2 ACTH Receptors


I. Introduction


II. Detection of ACTH Receptors


III. Characterization of ACTH Receptors in Rat Adrenocortical Cells


IV. ACTH Receptors in Human Adrenocortical Cells


V. ACTH Receptors in Rat Adipocytes


VI. ACTH Receptors in 3T3-L1 Cells


References


3 Biosynthesis of ACTH and Related Peptides


I. Introduction


II. Structure of POMC Gene and Protein in Different Species


III. Distribution and Site of Synthesis of POMC-Derived Peptides


IV. Regulation of Expression of POMC Genes


V. Processing of POMC in the Pituitary and Brain


VI. Processing Pathways of POMC in the Anterior and Neurointermediate Lobes of the Pituitary and the Brain


VII. Approaches to the Identification of Prohormone Processing Enzymes


VIII. Conclusions


References


4 ACTH and Corticosteroidogenesis


I. Introduction


II. Production of Steroids by the Adrenal Cortex


III. Stimulation of Steroid Synthesis


IV. Site of Action of ACTH in the Steroidogenic Pathway: Cholesterol Transport


V. The Role of Cyclic AMP


VI. The Role of Protein Synthesis


VII. The Role of Phosphorylation


VIII. The Role of Ca2+


IX. The Possible Role of Protein Kinase C


X. The Possible Role of Phospholipids


XI. The Roles of Subcellular Components of the Adrenal Cell


XII. Synthesis and Conclusions


References


5 Effect of ACTH and Other Proopiomelanocortin-Derived Peptide

Details

No. of pages:
212
Language:
English
Copyright:
© Academic Press 1987
Published:
Imprint:
Academic Press
eBook ISBN:
9780323160124

About the Editor

Choh Hao Li

Ratings and Reviews