Coronavirus Disease

From Origin to Outbreak

1st Edition - October 21, 2021
Editors: Adnan I. Qureshi, Omar Saeed, Uzma Syed
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 4 4 0 9 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 9 6 4 - 6

Coronavirus Disease: From Origin to Outbreak provides a comprehensive review of coronaviruses, particularly COVID-19, its transmission, and disease pathology. The book covers th… Read more

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Coronavirus Disease: From Origin to Outbreak provides a comprehensive review of coronaviruses, particularly COVID-19, its transmission, and disease pathology. The book covers the viral structure and genetics of coronaviruses, the pathogenesis and unique characteristics of coronavirus infection, and the evolving nature of our understanding of coronaviruses and disease. It also looks at the history of SARS-CoV and MERS-CoV infections and its global spread. The book examines the effectiveness of various preventive measures and new therapeutic agents that are either currently available or expected to available. Finally, it details the psychological and societal impact the virus and disease has in outbreak regions and what the financial impact an outbreak has on the healthcare system and local economies.

Cover image
Title page
Table of Contents
Copyright
Contributors
Chapter 1. Introduction
Chapter 2. History of SARS-CoV-2
Chapter 3. Zoonotic infections
Definition
Transmission
History of zoonoses
Emerging infections and virus spillover
Bat ecology
Challenges to control outbreak
Chapter 4. Global response
An enemy emerges
The virus marches on: East Asian countries
Europe will not be spared: Italy
Let us worship in peace: Pakistan
The new norm: the United States gets caught in a storm
The city that never sleeps
The dilemma of one of the largest gathering in the world
The search for a prevention
The need to monitor the cases
As Earth completes its revolution
Chapter 5. Coronavirus infection outbreak: comparison with other viral infection outbreak
Understanding SARS-CoV-2
Epidemic versus pandemic
Common features of epidemics
Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics
Gene structure of MERS-CoV, SARS-CoV, and SARS-CoV-2
Transmissibility and the basic reproductive rate
Incubation period of SARS-CoV-2 and viral excretion
Case fatality and risk of severe illness
Population-based mortality
Incidence of SARS-CoV-2 infections
Comparing SARS-CoV-2 and SARS-CoV spread
Conclusion
Chapter 6. SARS-CoV-2 viral structure and genetics
Introduction
Viral structure
Molecular genetics
Replication and gene expression
Replication transcription complexes
Basics of immune response
Viral host immune interactions
SARS-CoV-2 vaccines
Conclusions
Chapter 7. Clinical manifestation and diagnosis
Introduction
Transmission of COVID-19
Clinical manifestations
Diagnosis
Differential diagnosis
Viral persistence, convalescence, and recovery period
Precautionary guidelines set up by the Centers for Disease Control and Prevention regarding the testing process of COVID-19 and laboratory biosafety
Chapter 8. Treatment and therapeutic agents
Emergency use authorizations during the SARS-CoV-2 pandemic
Part I: Antiviral drug therapy Fig. 8.2
Part II: Immunomodulatory agents
Part III: Convalescent plasma, Intravenous immunoglobulin, and Cell-based therapies
Clinical Research
Part IV: Vaccine
Conclusion
Chapter 9. The economic repercussions of Coronavirus disease 2019 (COVID-19)
World economy December 2019
Major conflicts
Political impact of COVID-19
China's economic response to COVID-19
What industry relied on Wuhan for trade globally
Governments' economic response to COVID-19
A recession caused by SARS-CoV-2
Chapter 10. Psychological and social implications of COVID-19
Introduction
Impact on the society
Role of social platforms and media
Role of government and political leaders
Conclusion
Index

Adnan I. Qureshi

Dr. Qureshi is executive director, Zeenat Qureshi Institutes, and professor of Neurology at University of Missouri, Columbia. He has written over 670 scientific publications in prestigious journals including the New England Journal of Medicine, Lancet, Archives of Internal Medicine, Critical Care Medicine, Neurology, American Journal of Medicine, and Circulation. In addition, he has made over 2000 presentations in various national and international meetings. He has served as an invited speaker at numerous national and international forums. He has also been invited as visiting professor to universities in the United States and abroad. He is the editor of several textbooks and serves on editorial boards for several peer-review journals. He was the principal investigator of a large multinational clinical trial funded by National Institutes of Health. He has travelled extensively and written about Ebola virus disease epidemic after his visit to West Africa during the epidemic. His group led the study on Ebola virus disease survivors. He was also the editor for book on Zika virus disease. He laid the foundation of the Zeenat Qureshi Institutes in several countries including United States, China, Guinea, and Turkey. Since its inauguration, the institutes have led the way in cutting edge research in epidemiology, clinical trials, and basic research.

Affiliations and expertise

Zeenat Qureshi Institutes, and Department of Neurology, University of Missouri, Columbia

Omar Saeed

Dr. Omar Saeed graduated from medical school in Pakistan after which he pursued his interest in the field of medicine focusing on neurology and neuroimaging. He was given the opportunity to work with Dr. Adnan Qureshi at the Zeenat Qureshi Stroke Institute where he worked as a clinical research fellow. His main interests were stroke, intracerebral hemorrhage and neuroimaging among others. During his time at the stroke institute Dr. Saeed has co-authored several scientific publications in prestigious journals including Journal of Neurosurgery, Journal of Cerebrovascular disease, Journal of Neuroimaging and Journal of Vascular and Interventional Neurology. He was also given the opportunity to present at both national and international forums including the International Stroke Conference and The World Masters China Tour and Neuro Interventional International Forum. Furthermore Dr. Saeed has co-authored numerous research abstracts accepted to both the International Stroke Conference and the American Academy of Neurology Conference. His future hopes are to continue focusing on both the clinical and research side of medicine.

Affiliations and expertise

Research Fellow of the Zeenat Qureshi Stroke Institute, MN, USA

Uzma Syed

Dr. Uzma Syed is a TEDx speaker, author, infectious diseases and global health expert, and leader who speaks in media and conferences on both a national and global scale. She has led during the COVID-19 pandemic in her medical field, health system, local community, as well as for the broad Muslim community as the infectious disease expert on the National Muslim COVID-19 Task Force. She is a fellow of the Infectious Diseases Society of America (IDSA) AU:2 and was selected to be a part of the IDSA leadership Institute. Dr. Syed sits on numerous national committees including IDSA’s Inclusion, Diversity, Access & Equity Task Force as well as their Value Based Compensation Task Force. Dr. Syed was selected to serve on the Sepsis Alliance’s board of directors and cochairs the Equity, Diversity, and Inclusion committee of the Sepsis Alliance. She has been working with the Biden administration to promote vaccine and health equity as an executive member of Faiths4Vaccines and has partnered with USAID. She is passionate about education and mentorship and is the founder/CEO of Align Us, a youth career mentorship organization. She also leads The Eid Holiday Coalition, which provides resources and tools for communities to obtain Eid holidays in schools across the nation. Dr. Syed has been recognized as a trailblazer by many local, state, and national organizations for her work, including being presented with the prestigious national Muslim woman leadership award in the company of her excellency Emine Erdogan the first lady of Turkiye. Her humanitarian work has spanned from refugee resettlements to soup kitchens/toy drives. Dr. Syed gave the keynote address at the University of New England’s White Coat Ceremony for the class of 2026. Dr. Syed also shared her expertise at the 9th Annual Abu Dhabi Forum for Peace among global leaders and diplomats regarding global health, climate change, and food insecurities.

Affiliations and expertise

Partner, South Shore Infectious Diseases and Travel Medicine Consultants; Director of the Antimicrobial Stewardship Center of Excellence; Chairperson COVID-19 Task Force, Good Samaritan Hospital Medical Center, New York, USA