Coronavirus Disease

Coronavirus Disease

From Origin to Outbreak

1st Edition - October 21, 2021

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  • Editors: Adnan Qureshi, Omar Saeed, Uzma Syed
  • eBook ISBN: 9780323859646
  • Paperback ISBN: 9780128244098

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Coronavirus Disease: From Origin to Outbreak provides a comprehensive review of coronaviruses, particularly COVID-19, its transmission, and disease pathology. The book covers the viral structure and genetics of coronaviruses, the pathogenesis and unique characteristics of coronavirus infection, and the evolving nature of our understanding of coronaviruses and disease. It also looks at the history of SARS-CoV and MERS-CoV infections and its global spread. The book examines the effectiveness of various preventive measures and new therapeutic agents that are either currently available or expected to available. Finally, it details the psychological and societal impact the virus and disease has in outbreak regions and what the financial impact an outbreak has on the healthcare system and local economies.

Key Features

  • Provides an overview of the nature of infection, methods of spread, and history to better understand the principles of prevention and treatment of not only coronaviruses but also zoonotic infections in general
  • Makes comparisons with the impact of other viral infections such as Ebola virus disease, Zika virus disease, and Dengue virus disease which is key to learning from previous successful and unsuccessful strategies
  • Examines the global health perspective, population reaction, medical response to the COVID-19 pandemic


Researchers in virology, microbiology, infectious diseases, immunology

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Chapter 1. Introduction
  • Chapter 2. History of SARS-CoV-2
  • Chapter 3. Zoonotic infections
  • Definition
  • Transmission
  • History of zoonoses
  • Emerging infections and virus spillover
  • Bat ecology
  • Challenges to control outbreak
  • Chapter 4. Global response
  • An enemy emerges
  • The virus marches on: East Asian countries
  • Europe will not be spared: Italy
  • Let us worship in peace: Pakistan
  • The new norm: the United States gets caught in a storm
  • The city that never sleeps
  • The dilemma of one of the largest gathering in the world
  • The search for a prevention
  • The need to monitor the cases
  • As Earth completes its revolution
  • Chapter 5. Coronavirus infection outbreak: comparison with other viral infection outbreak
  • Understanding SARS-CoV-2
  • Epidemic versus pandemic
  • Common features of epidemics
  • Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics
  • Gene structure of MERS-CoV, SARS-CoV, and SARS-CoV-2
  • Transmissibility and the basic reproductive rate
  • Incubation period of SARS-CoV-2 and viral excretion
  • Case fatality and risk of severe illness
  • Population-based mortality
  • Incidence of SARS-CoV-2 infections
  • Comparing SARS-CoV-2 and SARS-CoV spread
  • Conclusion
  • Chapter 6. SARS-CoV-2 viral structure and genetics
  • Introduction
  • Viral structure
  • Molecular genetics
  • Replication and gene expression
  • Replication transcription complexes
  • Basics of immune response
  • Viral host immune interactions
  • SARS-CoV-2 vaccines
  • Conclusions
  • Chapter 7. Clinical manifestation and diagnosis
  • Introduction
  • Transmission of COVID-19
  • Clinical manifestations
  • Diagnosis
  • Differential diagnosis
  • Viral persistence, convalescence, and recovery period
  • Precautionary guidelines set up by the Centers for Disease Control and Prevention regarding the testing process of COVID-19 and laboratory biosafety
  • Chapter 8. Treatment and therapeutic agents
  • Emergency use authorizations during the SARS-CoV-2 pandemic
  • Part I: Antiviral drug therapy Fig. 8.2
  • Part II: Immunomodulatory agents
  • Part III: Convalescent plasma, Intravenous immunoglobulin, and Cell-based therapies
  • Clinical Research
  • Part IV: Vaccine
  • Conclusion
  • Chapter 9. The economic repercussions of Coronavirus disease 2019 (COVID-19)
  • World economy December 2019
  • Major conflicts
  • Political impact of COVID-19
  • China's economic response to COVID-19
  • What industry relied on Wuhan for trade globally
  • Governments' economic response to COVID-19
  • A recession caused by SARS-CoV-2
  • Chapter 10. Psychological and social implications of COVID-19
  • Introduction
  • Impact on the society
  • Role of social platforms and media
  • Role of government and political leaders
  • Conclusion
  • Index

Product details

  • No. of pages: 223
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: October 21, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780323859646
  • Paperback ISBN: 9780128244098

About the Editors

Adnan Qureshi

Dr. Qureshi is executive director, Zeenat Qureshi Institutes, and professor of Neurology at University of Missouri, Columbia. He has written over 670 scientific publications in prestigious journals including the New England Journal of Medicine, Lancet, Archives of Internal Medicine, Critical Care Medicine, Neurology, American Journal of Medicine, and Circulation. In addition, he has made over 2000 presentations in various national and international meetings. He has served as an invited speaker at numerous national and international forums. He has also been invited as visiting professor to universities in the United States and abroad. He is the editor of several textbooks and serves on editorial boards for several peer-review journals. He was the principal investigator of a large multinational clinical trial funded by National Institutes of Health. He has travelled extensively and written about Ebola virus disease epidemic after his visit to West Africa during the epidemic. His group led the study on Ebola virus disease survivors. He was also the editor for book on Zika virus disease. He laid the foundation of the Zeenat Qureshi Institutes in several countries including United States, China, Guinea, and Turkey. Since its inauguration, the institutes have led the way in cutting edge research in epidemiology, clinical trials, and basic research.

Affiliations and Expertise

Zeenat Qureshi Institutes, and Department of Neurology, University of Missouri, Columbia

Omar Saeed

Dr. Omar Saeed graduated from medical school in Pakistan after which he pursued his interest in the field of medicine focusing on neurology and neuroimaging. He was given the opportunity to work with Dr. Adnan Qureshi at the Zeenat Qureshi Stroke Institute where he worked as a clinical research fellow. His main interests were stroke, intracerebral hemorrhage and neuroimaging among others. During his time at the stroke institute Dr. Saeed has co-authored several scientific publications in prestigious journals including Journal of Neurosurgery, Journal of Cerebrovascular disease, Journal of Neuroimaging and Journal of Vascular and Interventional Neurology. He was also given the opportunity to present at both national and international forums including the International Stroke Conference and The World Masters China Tour and Neuro Interventional International Forum. Furthermore Dr. Saeed has co-authored numerous research abstracts accepted to both the International Stroke Conference and the American Academy of Neurology Conference. His future hopes are to continue focusing on both the clinical and research side of medicine.

Affiliations and Expertise

Research Fellow of the Zeenat Qureshi Stroke Institute, MN, USA

Uzma Syed

Dr Uzma Syed is a board-certified Infectious Disease specialist, Chair of the COVID-19 Task Force, Director of the Antimicrobial Stewardship Center of Excellence at Good Samaritan Hospital Medical Center and partner at South Shore Infectious Diseases and Travel Medicine Consultants. Dr Syed is well-published in pneumonia-related research and has been leading several COVID-19 clinical trials. Dr Syed is a fellow of the Infectious Diseases Society of America as well as member of their Inclusion, Diversity, Access & Equity Task Force. Dr Syed holds regular town halls educating the public in order to build vaccine confidence across diverse communities. Dr Syed was featured on Tedx for her talk on COVID-19 The Ripple Effect from neighborhoods to beyond. Dr Syed cares passionately about education. She is the founder & CEO of a 501c3 organization Align Us Inc, which provides career mentorship or high school students. She teaches students of all ages as well as medical residents about her specialty. She’s a community and youth leader with a focus on teen initiatives as a leading member of the Interfaith Council of Syosset-Woodbury-Jericho. Dr Syed co-founded the Eid Holiday Coalition Long Island and founded the National Eid Coalition helping over two dozen school districts obtain Eid holidays. Dr Syed serves on the Nassau County Police Commissioner’s Community Council, she was recognized by the Nassau County Legislature as a female trailblazer and received the Woman of Distinction award by the town of Oyster Bay. Her humanitarian work has spanned from refugee resettlement to annual school supply and holiday toy drives to serving at soup kitchens. Dr Syed has volunteered with UNICEF for children’s rights, the Global Youth Assembly and the United Nations to help promote mobile health to underserved countries. Dr Syed has been featured as an expert on several media outlets as an expert in Infectious Diseases including BBC, CBS, ABC NPR, and others.

Affiliations and Expertise

South Shore Infectious Diseases, Bayshore; Travel Medicine Consultants and Antibiotic Infusion Center, Syosset, NY, USA

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