A critical factor in cell-to-cell interactions is the presence in the cell membrane of highly specific ion channels controlled by specific receptors that are bound to, and activated by, a gamut of external hormones and neurotransmitters. Through both this action on ion channels, and action on other membrane components (such as G-proteins), extracellular signals alter intracellular events, usually through the mediation of second messengers, and so provide the basis for the transduction mechanism connecting extracellular signals with intracellular effectors. This volume deals with the various ways that such membrane function is controlled.

Table of Contents

Preface. Dedication. Contributors. Acknowledgements. Signal Transduction. Signalling through phospholipid breakdown (J.H. Exton). Receptor-mediated activation of phospholipase A2 (J. Axelrod). Protein phosphorylation in the nervous system (R.L. Huganir). Alpha-adrenergic inhibition of N-type calcium channels and neurotransmitter release in sympathetic neurones (D. Lipscombe, S. Kongsamut and R.W. Tsien). Release of vasoactive intestinal peptide (VIP) in mouse neocortex: Ca2+-channel subtypes and involvement of arachidonic acid metabolites (J-L. Marin and P.J. Magistretti). The effects of calcium channel agonists and antagonists on the binding of [3H] nitrendipine to synaptic membrane and postsynaptic density factions isolated from canine cerebral cortex. Evidence for a separate-site model for agonists and antagonists (P. Siekevitz and M. Ledoux). Adaptive changes in signal transduction systems: Molecular mechanisms of opiate addiction in rate locus coeruleus (E.J. Nestler). Does catecholamine-induced sequestration of beat-adrenergic receptors involve endocytosis via the clathrin-coated PIT pathway (J.P. Perkins). The molecular components of the olfactory signal transduction cascade (R.R. Reed, H.A. Bakalyar, P.G. Feinstein and D.T. Jones). The control of photoreceptor sensitivity (T.D. Lamb and V. Torre). Receptor Structure and Function. What the structure of the acetylocholine receptor tells us about the function of the ligand gated ion channel family (R.M. Stroud). Characteristics of acetylcholine receptor-channels stably expressed in fibroblasts (T. Claudio). The structure of the NMDA receptor-channel complex (P. Ascher and J. Johnson). Are receptor-associated nuclear proteins associated with the earliest effects of steroid hormones? (E-E. Baulieu, N. Binart, F. Cadepond, M-G. Catelli, B. Chambraud, J. Garnier, J-M. Gasc, G. Groyer-Schweizer, M-E. Rafestin-Oblin, C. Radanyi, G. Reduilh, J-M. Renoir and M. Sa


© 1990
Elsevier Science
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