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Control of Animal Cell Proliferation - 1st Edition - ISBN: 9780121230623, 9781483276663

Control of Animal Cell Proliferation

1st Edition

Volume II

Editors: Alton L. Boynton Hyam L. Leffert
eBook ISBN: 9781483276663
Imprint: Academic Press
Published Date: 28th January 1987
Page Count: 528
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Control of Animal Cell Proliferation, Volume II discusses how animal cells become proliferatively autonomous, which results in malignant behavior. This book begins with trends and issues on membrane structure and teratocarcinoma research. The structure and function of several growth factors and their receptors such as thrombin, transferrin, glucocorticoid, and B and T cell factors are also discussed. This text likewise covers the mechanism of information transduction that includes intracellular pH and calcium. The aspects of genome organization and gene transcription are deliberated in the last chapters. This publication provides biologists and students with a coherent picture of cell proliferation.

Table of Contents



Contents of Volume 1

I. Trends and Issues

1 Membrane Structure and Function

I. Introduction

II. Membrane Organization

III. Membrane Dynamics

IV. Diffusion-Coupled Reactions and Membrane Function

V. Some Current Problems in Membrane Structure

VI. Concluding Comment


2 Trends in Teratocarcinoma Research

I. Introduction

II. Embryo-Derived Stem Cells

III. Growth Factors and Oncogenes

IV. Conclusions and Prospects


II. Growth Factors

3 Transforming Growth Factors

I. Introduction

II. Transforming Growth Factor Type α

III. Transforming Growth Factor Type ß

IV. Other Transforming Growth Factors

V. Summary and Conclusions


4 Commitment in Blood Cell Differentiation: Erythropoietin as an Instructive Signal

I. Introduction

II. Biologically Active Factors

III. Precursor Cells

IV. Models of Blood Cell Differentiation


5 Granulocyte-Macrophage Colony-Stimulating Factors

I. Introduction

II. Murine Granulocyte-Macrophage Colony-Stimulating Factors

III. CSFs and Oncogenes

IV. Actions of the CSFs

V. In Vivo Significance of the CSFs

VI. Summary


6 Structural Regions and Bioregulatory Functions of Thrombin

I. Introduction

II. Prothrombin Structure

III. Thrombin Structure

IV. Active-Site Regions

V. Specificity and Bioregulatory Functions


7 Transferrin

I. Introduction

II. Isolation and Purification of Transferrin

III. Physical Properties of Transferrin

IV. Ligands of the Metal and Anion Binding Sites

V. The Synergistic Anion Binding Site

VI. Iron Exchange by Transferrin


8 Glucocorticoid Enhancement of Cellular Proliferation In Vitro

I. Introduction

II. Effects of Glucocorticoids on Cellular Proliferation

III. Additional Effects of Glucocorticoids In Vitro

IV. Enhanced Proliferation of Human Fetal Lung Fibroblasts in the Presence of Glucocorticoid-Conditoned Medium

V. Summary


9 B Cell and T Cell Growth Factors

I. Overview

II. Consensus Model of the T Cell Response

III. Consensus Model of the B Cell Response

IV. History

V. T Cell Growth Factors

VI. B Cell Growth Factors

VII. Summary and Conclusions


III. Receptors

10 Characterization of the Thrombin Receptor and Its Involvement in Initiation of Cell Proliferation

I. Introduction

II. Demonstration of High-Affinity Thrombin Receptors

III. Visualization of Thrombin Binding Sites

IV. Internalization and Degradation of Thrombin: Thrombin Receptors vs. Protease-Nexin

V. Receptor-Cytoskeletal Interactions

VI. Characterization of Thrombin Receptors on Fibroblasts

VII. Role of Thrombin Receptors in Initiation of Cell Proliferation

VIII. Characterization of Thrombin Mitogenic Signals

IX. Two-Signal Model for Thrombin Mitogenesis

X. Effect of Transformation on Thrombin Binding and Effect of Thrombin on Transformation


11 The Transferrin Receptor

I. Introduction

II. Transferrin Receptor Expression and Cell Proliferation

III. Evidence for Possible Roles for Transferrin Receptor Other Than Cellular Iron Uptake

IV. Conclusions


12 Glucocorticoid Hormone Receptors

I. Introduction

II. Receptor Assays

III. Purification of Glucocorticoid Receptors

IV. Structure of the Glucocorticoid Receptor

V. Cellular Localization of Glucocorticoid Receptors

VI. Functional Consequences of Activation

VII. Genetic Analysis of Glucocorticoid Receptors


13 The Antigen Receptor on T Cells

I. Ligand Specificity of T Lymphocytes

II. Structure of the Antigen/MHC Receptor on T Cells

III. Structure of the a and ß Chains of the Receptor


IV. Transduction Mechanisms

14 Intracellular pH and Cell Proliferation

I. Introduction

II. pH1 and Initiation of Cell Division

III. Properties and Mechanism of the pHj Increase

IV. Is the pH1 Change Necessary for Fertilization?

V. Is the pH1 Change Necessary for Growth Factor Action?

VI. How Might Na+-H+/pH1 Changes Cause Mitogenesis?

VII. Summary and Prognosis

VIII. Is a New View of pHi Required?


15 Intracellular Calcium and Normal Eukaryotic Cell Growth

I. Introduction

II. Intracellular Calcium Regulation

III. Calcium and Lymphocyte Activation

IV. Calcium and the Activation of Quiescent Fibroblasts

V. Common Patterns of Ionic Responses

VI. Conclusions


V. Regulation

16 Organization, Structure, and Function of Interspersed Repeated DNA Sequences in Mouse and Human Genomes

I. Introduction and Background

II. Genome Organization from the Perspective of Interspersed Repeated DNA Sequence Families

III. Interspersed Repeated DNA Sequences in Mouse and Human Genomes: Structural Features and Their Implied Functional Significance

IV. Concluding Notes


17 Molecular Mechanisms of Epidermal Growth Factor Regulation of Prolactin Gene Transcription

I. Introduction

II. Transcriptional Regulation of Gene Expression by Polypeptide Hormones

III. Nuclear Effects of EGF Blocked by Cobalt Chloride

IV. EGF Effects on Other Transcription Units

V. Mechanisms of Attenuation of Transcriptional Responses

VI. Concluding Remarks




No. of pages:
© Academic Press 1987
28th January 1987
Academic Press
eBook ISBN:

About the Editors

Alton L. Boynton

Hyam L. Leffert

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