Control of Animal Cell Proliferation

Control of Animal Cell Proliferation

Volume II

1st Edition - January 28, 1987

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  • Editors: Alton L. Boynton, Hyam L. Leffert
  • eBook ISBN: 9781483276663

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Control of Animal Cell Proliferation, Volume II discusses how animal cells become proliferatively autonomous, which results in malignant behavior. This book begins with trends and issues on membrane structure and teratocarcinoma research. The structure and function of several growth factors and their receptors such as thrombin, transferrin, glucocorticoid, and B and T cell factors are also discussed. This text likewise covers the mechanism of information transduction that includes intracellular pH and calcium. The aspects of genome organization and gene transcription are deliberated in the last chapters. This publication provides biologists and students with a coherent picture of cell proliferation.

Table of Contents

  • Contributors


    Contents of Volume 1

    I. Trends and Issues

    1 Membrane Structure and Function

    I. Introduction

    II. Membrane Organization

    III. Membrane Dynamics

    IV. Diffusion-Coupled Reactions and Membrane Function

    V. Some Current Problems in Membrane Structure

    VI. Concluding Comment


    2 Trends in Teratocarcinoma Research

    I. Introduction

    II. Embryo-Derived Stem Cells

    III. Growth Factors and Oncogenes

    IV. Conclusions and Prospects


    II. Growth Factors

    3 Transforming Growth Factors

    I. Introduction

    II. Transforming Growth Factor Type α

    III. Transforming Growth Factor Type ß

    IV. Other Transforming Growth Factors

    V. Summary and Conclusions


    4 Commitment in Blood Cell Differentiation: Erythropoietin as an Instructive Signal

    I. Introduction

    II. Biologically Active Factors

    III. Precursor Cells

    IV. Models of Blood Cell Differentiation


    5 Granulocyte-Macrophage Colony-Stimulating Factors

    I. Introduction

    II. Murine Granulocyte-Macrophage Colony-Stimulating Factors

    III. CSFs and Oncogenes

    IV. Actions of the CSFs

    V. In Vivo Significance of the CSFs

    VI. Summary


    6 Structural Regions and Bioregulatory Functions of Thrombin

    I. Introduction

    II. Prothrombin Structure

    III. Thrombin Structure

    IV. Active-Site Regions

    V. Specificity and Bioregulatory Functions


    7 Transferrin

    I. Introduction

    II. Isolation and Purification of Transferrin

    III. Physical Properties of Transferrin

    IV. Ligands of the Metal and Anion Binding Sites

    V. The Synergistic Anion Binding Site

    VI. Iron Exchange by Transferrin


    8 Glucocorticoid Enhancement of Cellular Proliferation In Vitro

    I. Introduction

    II. Effects of Glucocorticoids on Cellular Proliferation

    III. Additional Effects of Glucocorticoids In Vitro

    IV. Enhanced Proliferation of Human Fetal Lung Fibroblasts in the Presence of Glucocorticoid-Conditoned Medium

    V. Summary


    9 B Cell and T Cell Growth Factors

    I. Overview

    II. Consensus Model of the T Cell Response

    III. Consensus Model of the B Cell Response

    IV. History

    V. T Cell Growth Factors

    VI. B Cell Growth Factors

    VII. Summary and Conclusions


    III. Receptors

    10 Characterization of the Thrombin Receptor and Its Involvement in Initiation of Cell Proliferation

    I. Introduction

    II. Demonstration of High-Affinity Thrombin Receptors

    III. Visualization of Thrombin Binding Sites

    IV. Internalization and Degradation of Thrombin: Thrombin Receptors vs. Protease-Nexin

    V. Receptor-Cytoskeletal Interactions

    VI. Characterization of Thrombin Receptors on Fibroblasts

    VII. Role of Thrombin Receptors in Initiation of Cell Proliferation

    VIII. Characterization of Thrombin Mitogenic Signals

    IX. Two-Signal Model for Thrombin Mitogenesis

    X. Effect of Transformation on Thrombin Binding and Effect of Thrombin on Transformation


    11 The Transferrin Receptor

    I. Introduction

    II. Transferrin Receptor Expression and Cell Proliferation

    III. Evidence for Possible Roles for Transferrin Receptor Other Than Cellular Iron Uptake

    IV. Conclusions


    12 Glucocorticoid Hormone Receptors

    I. Introduction

    II. Receptor Assays

    III. Purification of Glucocorticoid Receptors

    IV. Structure of the Glucocorticoid Receptor

    V. Cellular Localization of Glucocorticoid Receptors

    VI. Functional Consequences of Activation

    VII. Genetic Analysis of Glucocorticoid Receptors


    13 The Antigen Receptor on T Cells

    I. Ligand Specificity of T Lymphocytes

    II. Structure of the Antigen/MHC Receptor on T Cells

    III. Structure of the a and ß Chains of the Receptor


    IV. Transduction Mechanisms

    14 Intracellular pH and Cell Proliferation

    I. Introduction

    II. pH1 and Initiation of Cell Division

    III. Properties and Mechanism of the pHj Increase

    IV. Is the pH1 Change Necessary for Fertilization?

    V. Is the pH1 Change Necessary for Growth Factor Action?

    VI. How Might Na+-H+/pH1 Changes Cause Mitogenesis?

    VII. Summary and Prognosis

    VIII. Is a New View of pHi Required?


    15 Intracellular Calcium and Normal Eukaryotic Cell Growth

    I. Introduction

    II. Intracellular Calcium Regulation

    III. Calcium and Lymphocyte Activation

    IV. Calcium and the Activation of Quiescent Fibroblasts

    V. Common Patterns of Ionic Responses

    VI. Conclusions


    V. Regulation

    16 Organization, Structure, and Function of Interspersed Repeated DNA Sequences in Mouse and Human Genomes

    I. Introduction and Background

    II. Genome Organization from the Perspective of Interspersed Repeated DNA Sequence Families

    III. Interspersed Repeated DNA Sequences in Mouse and Human Genomes: Structural Features and Their Implied Functional Significance

    IV. Concluding Notes


    17 Molecular Mechanisms of Epidermal Growth Factor Regulation of Prolactin Gene Transcription

    I. Introduction

    II. Transcriptional Regulation of Gene Expression by Polypeptide Hormones

    III. Nuclear Effects of EGF Blocked by Cobalt Chloride

    IV. EGF Effects on Other Transcription Units

    V. Mechanisms of Attenuation of Transcriptional Responses

    VI. Concluding Remarks



Product details

  • No. of pages: 528
  • Language: English
  • Copyright: © Academic Press 1987
  • Published: January 28, 1987
  • Imprint: Academic Press
  • eBook ISBN: 9781483276663

About the Editors

Alton L. Boynton

Hyam L. Leffert

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