Contemporary Management of Metastatic Colorectal Cancer

Contemporary Management of Metastatic Colorectal Cancer

A Precision Medicine Approach

1st Edition - September 1, 2022

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  • Editors: Aslam Ejaz, Timothy Pawlik
  • Paperback ISBN: 9780323917063

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Contemporary Management of Metastatic Colorectal Cancer: A Precision Medicine Approach summarizes current knowledge and provides evidenced-based practice recommendations on how to treat patients with metastatic colorectal cancer. The book presents topics such as pre-operating imaging, the use of molecular markers in treatment decisions, neoadjuvant therapy, synchronous colorectal liver metastasis, and minimally invasive approaches. In addition, it discusses immunotherapy, targeted therapies and survivorship. This is a valuable resource for practitioners, cancer researchers, oncologists, graduate students and members of biomedical research who need to understand more about novel treatments for colorectal cancer metastasis.

Key Features

  • Summarizes contemporary data in the workup and treatment of patients with metastatic colorectal cancer
  • Discusses novel patient-centric personalized approaches surrounding the management of such cancer types
  • Presents evidenced-based recommendations for precision care among patients with metastatic colorectal cancer


Medical doctors, oncologists, practitioners, cancer researchers

Table of Contents

  • 1. Epidemiology and Risk Factors for Metastatic Colorectal Disease
    2. Molecular Pathogenesis, Tumor Microenvironment and Future Therapeutic Targets: Colorectal Liver Metastasis
    3. Pre-operative Imaging, Response Evaluation, and Surgical Planning – CT, PET, Radiomics, FLR Measurement
    4. Use of Molecular Markers and Other Personalized factors in Treatment Decisions (KRAS, sidedness etc.)
    5. Role of Neoadjuvant Therapy in Treatment of Patients with Colorectal Liver Metastasis
    6. Management of the Disappeared Colorectal Liver Metastasis
    7. Approach to Small Liver Remnant – Strategies to Increase Resectability
    8. Two-Stage versus ALPPS for Large Intrahepatic Burden of Colorectal Liver Metastasis
    9. Synchronous Colorectal Liver Metastasis – Simultaneous vs. Staged Approach
    10. Minimally Invasive Approaches to Metastatic Colorectal Cancer
    11. Hepatic Resection of Colorectal Liver Metastasis in the Presence of Extrahepatic Disease
    12. Locoregional Approaches to Colorectal Liver Metastasis – Ablation
    13. Locoregional Approaches to Colorectal Liver Metastasis - Intra-arterial
    14. Locoregional Approaches to Colorectal Liver Metastasis - Radiation Options
    15. Adjuvant Therapy following Resection of Colorectal Liver Metastasis
    16. Long-term Prognosis and Surveillance of Patients with Resected Colorectal Liver Metastasis
    17. Management of Secondary Recurrence of Intra-hepatic Colorectal Liver Metastasis following Initial Hepatic Resection
    18. Immunotherapy and Targeted Therapies for Colorectal Liver Metastasis
    19. Colorectal Liver Metastasis: Survivorship

Product details

  • Language: English
  • Copyright: © Academic Press 2022
  • Published: September 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323917063

About the Editors

Aslam Ejaz

Aslam Ejaz MD, MPH is a surgical oncologist who specializes in the treatment of pancreatic cancer, liver cancer, bile duct cancer and other gastrointestinal cancers. In addition to his clinical work, he is dedicated to teaching the future generation of surgeons and other cancer care providers as an assistant professor in the Division of Surgical Oncology at The Ohio State University. As a member of the Translational Therapeutics Program at the OSUCCC – James, one of his research interests is in the development of clinical trials to help patients receive new therapies that may not be available at other treatment centers. He is also interested in researching how patients do after surgery as well as addressing variations in perioperative surgical care and quality improvement. Dr. Ejaz’s research is dedicated to improving cancer care, and he has published over 100 peer-reviewed papers in high-impact cancer and surgical journals.

Affiliations and Expertise

The Ohio State University, Wexner Medical Center, Columbus, USA

Timothy Pawlik

Timothy M. Pawlik MD, MPH, MTS, PhD received his undergraduate degree from Georgetown University and his medical degree from Tufts University School of Medicine. Dr. Pawlik completed surgical training at the University of Michigan Hospital and spent two years at the Massachusetts General Hospital as a surgical oncology research fellow. He then went on for advanced training in surgical oncology at The University of Texas M. D. Anderson Cancer Center in Houston. His main clinical interests include alimentary tract surgery, with a special interest in hepatic, pancreatic and biliary diseases. Dr. Pawlik also has an interest in medical ethics and completed a fellowship in medical ethics at the Harvard School of Public Health. In addition, Dr. Pawlik was the recipient of a Clinical and Translational Science Award (CTSA) KL2 Research Scholar Award and received a PhD from the Johns Hopkins Bloomberg School of Public Health in Clinical Investigations.

Affiliations and Expertise

The Ohio State University, Wexner Medical Center, Columbus, USA

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