Conn's Translational Neuroscience

Conn's Translational Neuroscience

1st Edition - September 28, 2016

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  • Editor: P. Michael Conn
  • eBook ISBN: 9780128025963
  • Hardcover ISBN: 9780128023815

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Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance.

Key Features

  • Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance
  • Features contributions from leading global basic and clinical investigators in the field
  • Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes
  • Relates and translates the current science to the understanding of neurological disorders and their treatment


Researchers, students, and practitioners in the fields of neurology and neuroscience

Table of Contents

  • 1. Cytology of the Central Nervous System - Lothar Jennes
    2. Ion Channels - Bryan S. Barker, Gareth T. Young, Camille H. Soubrane, Gary J. Stephens, Edward B. Stevens and Manoj Patel
    2.1 Translational Correlation: Temporal Lobe Epilepsy and Hippocampal Sclerosis - John C. DeToledo, Inhyup Kim and Sahawat Tantikittichaikul
    3. Neurotransmitters and Neurotransmission in the Developing and Adult Nervous System - Steven L. Miller and Hermes H. Yeh
    3.1 Translational Correlation: Myasthenia Gravis and Other Neuromuscular Junction Disorders - Ahmed M. El-Dokla and Sara T. Ali
    4. Synaptic Development - Ania Dabrowski, Erin Johnson-Venkatesh and Hisashi Umemori
    5. The Peripheral and Central Nervous System - Sam Franklin
    5.1 Translational Correlation: Peripheral Neuropathy - Ahmed M. El-Dokla and Sara T. Ali
    5.2 Translational Correlation: Guillain-Barré Syndrome - Ahmed M. El-Dokla and Sara T. Ali
    6. The Blood-Brain Barrier: A Restricted Gateway to the Brain - Kaushik Shah and Tom Abbruscato
    7. Autoregulation of Cerebral Blood Flow - John C. DeToledo and Doungporn Ruthirago
    7.1 Translational Correlation: Stroke - Jongyeol Kim, Yazan Alderazi and Rashedul Hasan
    7.2 Translational Correlation: Migraine - Doungporn Ruthirago, Parunyou Julayanont and Jongyeol Kim
    8. The Vestibular System - Rand Swenson
    8.1 Translational Correlation: Vertigo - Byungkwan Hwang and Jongyeol Kim
    9. The Cerebellum - Charles R. Goodlett and Guy Mittleman
    9.1 Translational Correlation: Disorders of the Cerebellum - Henrik Wilms and Pavis Laengvejkal
    10. The Basal Ganglia - Imran Noorani
    10.1 Translational Correlation: Disorders of the Basal Ganglia - Henrik Wilms and Angel O. Claudio
    11. Choroid Plexus – Cerebrospinal Fluid Transport Dynamics:  Support of Brain Health and a Role in Neurotherapeutics - Conrad E. Johanson
    12. The Cerebral Cortex - Rand Swenson
    13. The Thalamus - Fred A. Lenz
    14. Cranial Nerves and Brainstem - Rafey A. Feroze, Alp Ozpinar, Nima Alan and Raymond F. Sekula
    14.1 Translational Correlation: Bell’s Palsy - John C. DeToledo and Jongyeol Kim
    15. Hypothalamic-Pituitary Regulation - Shlomo Melmed
    16. Neuroendocrinimmunology: A Primer - Michael D. Lumpkin
    16.1 Translational Correlation: Clinical Neuroimmunology - J. Chad Hoyle, Dustin M. Welch and Michael K. Racke
    16.2 Translational Correlation: Multiple Sclerosis - Mirla Avila, Annette Okai and John C. DeToledo
    17. The Olfactory System - Casey Trimmer and Joel D. Mainland
    18. Intranasal Trigeminal Chemoreception - Syrina Al Aïn and Johannes A. Frasnelli
    19. Vision - J. Fielding Hejtmancik, Patricia Cabrera, Yabin Chen, Oussama M'Hamdi and John M. Nickerson
    20. Oculomotor Systems and Control - David M. Waitzman
    21. A Modern Clinicopathological Approach to Traumatic Brain Injury - Vassilis Koliatsos, Leyan Xu, Jiwon Ryu and Nikolaos Ziogas
    21.1 Translational Correlation: Disorders of the Spinal Cord - Saša Živković, Sara T. Ali and Ahmed M. El-Dokla
    21.2 Translational Correlation: Abnormalities of the CSF System - Sahawat Tantikittichaikul and John C. DeToledo
    22. Posttraumatic Stress Disorder - Gary Wynn, David M. Benedek, Luke Johnson, Kwang H. Choi, Lei Zhang, Xian-Zhang Hu, Harvey Pollard and Robert J. Ursano
    23. Somatosensation and Pain - Steven A. Prescott and Stéphanie Ratté
    23.1 Translational Correlation: Trigeminal Neuralgia - Jongyeol Kim and Ahmed M. El-Dokla
    24. Neurogenesis as a Factor in the Functional Plasticity of the Nervous System - Aixa Alfonso
    25. Axonal Degeneration and Regeneration in the Peripheral and Central Nervous Systems - Paul J. Reier, Lyandysha Viktorovna Zholudeva and Michael A. Lane
    25.1 Translational Correlation: Sarcopenia - Byungkwan Hwang and John C. DeToledo
    26. Audition - Jennifer K. Bizley
    27. Body Clocks in Health and Disease - IIia Karatsoreos and Rae Silver
    27.1 Translational Correlation: Sleep Disorders - Sasikanth Gorantla, Jessica Vensel-Rundo and John C. DeToledo
    28. The Experience of Consciousness - Peter T. Morgan
    29. The Emotional Brain - Luiz Pessoa
    29.1 Translational Correlation: Limbic Encephalitis - Chuang-Kuo Wu and Sasikanth Gorantla
    30. Stress, Mood and Pathways to Depression - K. Ranga R. Krishnan
    31. Language Processing, Development and Evolution - Marco Catani and Matt S. Dawson
    32. Memory - Miriam L.R. Meister and Elizabeth Buffalo
    32.1 Translational Correlation: Alzheimer’s Disease - Chuang-Kuo Wu
    33. Neurobiology of Drugs of Abuse - Nachum Dafny and Gary Rosenfeld

Product details

  • No. of pages: 776
  • Language: English
  • Copyright: © Academic Press 2016
  • Published: September 28, 2016
  • Imprint: Academic Press
  • eBook ISBN: 9780128025963
  • Hardcover ISBN: 9780128023815

About the Editor

P. Michael Conn

Dr. P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center. He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone in the pituitary and therapeutic approaches that restore misfolded proteins to function. His lab is credited with the first demonstrations of GPCR internalization and oligomerization. His work has led to drugs that have benefitted humans and animals. Most recently, his lab identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications and written or edited over 225 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the Miguel Aleman Prize of Mexico and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation.

Affiliations and Expertise

Robert C. Kimbrough, III, MD, Professor of Medical Education, Texas Tech University Health Sciences Center, Lubbock, TX, USA

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