Connectomic Deep Brain Stimulation

Connectomic Deep Brain Stimulation

1st Edition - September 10, 2021

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  • Editor: Andreas Horn
  • Paperback ISBN: 9780128218617
  • eBook ISBN: 9780128218624

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Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson’s Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more.  This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery.

Key Features

  • Written to provide a "hands-on" approach for neuroscience graduate students, as well as medical personnel from the fields of neurology and neurosurgery
  • Includes preprocessing strategies (such as co-registration, normalization, lead localization, VTA estimation and fiber-tracking approaches)
  • Presents references (key articles, books and protocols) for additional detailed study
  • Provides data analysis boxes in each chapter to help with data interpretation


Graduate students in biological and biomedical sciences, neuroscientists, clinicians (especially neurosurgery, neurology and neuroradiology), biomedical scientists, post-doctoral fellows, researchers

Table of Contents

  • Part I: Deep Brain Stimulation and Connectomics – A Fruitful Marriage?
    1. Deep Brain Stimulation – an Introduction
    2. The “connectomic revolution” in the field of neuroimaging
    3. The mechanism of deep brain stimulation
    Part II: DBS Imaging Methods
    4. DBS Imaging - An Overview
    5. DBS Imaging Methods I: Preprocessing
    6. DBS Imaging Methods II: Electrode Localization
    7. DBS Imaging Methods III: Estimating the electric field and Volume of Tissue Activated
    8. DBS Imaging Methods IV: Stereotactic Spaces
    9. DBS Imaging Methods IV: Group Analyses
    Part III: Connectomics in DBS
    10. Resting-State functional MRI based Connectivity
    11. Diffusion-weighted MRI based Connectivity
    12. Normative Connectomes and their use in DBS
    13. Investigating Network Effects of DBS with fMRI
    14. High-Resolution Resources and Histological Mesh Tractography
    15. Using brain lesions to inform connectomic DBS
    16. Electrophysiological connectivity measures from DBS-targets in Parkinson’s disease and Dystonia
    Part IV: Applications of Connectomic DBS
    17. Predicting treatment response on a local level
    18. Predicting treatment response based on DBS connectivity
    19. Connectomic DBS in Parkinson’s Disease, Essential Tremor and Dystonia
    20. Connectomic DBS in Major Depression
    21. Connectomic DBS in Obsessive Compulsive Disorder
    22. Connectomics in the Operation Room
    23. Investigating cognitive neuroscience concepts using connectomic DBS
    24. Combining invasive and noninvasive neuromodulation techniques via connectomics
    Part V: Outlook
    25. Outlook: Toward Personalized Connectomic Deep Brain Stimulation
    26. Whole-brain modelling to predict optimal DBS targeting

Product details

  • No. of pages: 600
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: September 10, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780128218617
  • eBook ISBN: 9780128218624

About the Editor

Andreas Horn

Andreas Horn is the Director of Deep Brain Stimulation Research within the Center for Brain Circuit Therapeutics at Brigham and Women’s Hospital and Director of Connectomic Neuromodulation Research at Massachusetts General Hospital. Furthermore, he leads the network stimulation laboratory in Boston and Berlin (, where the main aims are to analyze and modulate brain networks that may improve treatment for various brain disorders. Central to the laboratory is the procedure of deep brain stimulation, in which fine electrodes are stereotactically implanted into deep structures of the brain to deliver weak electric pulses to specific structures. A second key concept is the one of the human connectome: A mathematical description of brain regions and their interconnections – in other words, a wiring-diagram of the human brain. By leveraging this concept, the laboratory investigates the impact of focal and multifocal brain stimulation techniques on distributed whole-brain networks. The laboratory leads development of an award-winning and widely used open source software ( that facilitates these kinds of studies. By developing this software alongside critical methodology, the laboratory was able to combine research on the fields of deep brain stimulation and the human connectome over the last ten years. In doing so, the laboratory has published central work toward establishing a novel and growing field of connectomic deep brain stimulation.

Affiliations and Expertise

Movement Disorders and Neuromodulation Section, Department of Neurology, Charité – Universitätsmedizin Berlin, Berlin, Germany

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