Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds

Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds

1st Edition - May 16, 1994

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  • Editors: J. August, Ferid Murad
  • eBook ISBN: 9780080581187

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Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics.This special volume of Advances in Pharmacology features a two-color dust jacket.

Key Features

Summarizes the most recent information on:

  • Xenobiotic conjugation
  • Drug toxicity, hypersensitivity, and targeting
  • Chemical carcinogenesis
  • Glutathione-, sulfate conjugate-, and glucuranide conjugate-dependent toxicity
  • Bioactivation and bioconversion


Researchers in biochemistry, bioorganic chemistry, medicinal and pharmaceutical chemistry, pharmacology, and toxicology.

Table of Contents

  • J.A. Miller and Y.-J. Surh, Historical Perspectives on Conjugation-Dependent Bioactivation of Foreign Compounds.
    Glutathione-Dependent Toxicity:
    C. Andersson, E. Mosialou, R. Weinander, and R. Morgenstern, Enzymology of Microsomal Glutathione S-Transferase.
    B. Ketterer and L.G. Christodoulides, Enzymology of Cytosolic Glutathione S-Transferases.
    A.J.L. Cooper, Enzymology of Cysteine S-Conjugate b-Lyases.
    W. Dekant, S. Vamvakas,and M.W. Anders, Formation and Fate of Nephrotoxic and Cytotoxic Glutathione S-Conjugates: Cysteine Conjugate b-Lyase Pathway.
    T.A. Baille and K. Kassahun, Reversibility in Glutathione-Conjugate Formation.
    T.J. Monks and S.S. Lau, Glutathione Conjugation as a Mechanism for the Transport of Reactive Metabolites.
    F.P. Guengerich, Metabolism and Genotoxicity of Dihaloalkanes.
    R. Munday, Bioactivation of Thiols by One-Electron Oxidation.
    N. Ballatori, Glutathione Mercaptides as Transport Forms of Metals.
    Sulfate Conjugate-Dependent Toxicity:
    C.N. Falany and T.W. Wilborn, Biochemistry of Cytosolic Sulfotransferases Involved in Bioactivation.
    C.J. Michejda and M.B.K. Koepke, Carcinogen Activation by Sulfate Conjugate Formation.
    Glucuronide Conjugate-Dependent Toxicity:
    K.W. Bock UDP-Glucuronsyltransferases and Their Role in Metabolism and Disposition of Carcinogens.
    P. Zia-Amirhosseini, H. Spahn-Langguth, and L.Z. Benet, Bioactivation of Glucuronide-Conjugate Formation. Bioactivation and Bioconversion:
    P.E. Hanna, N-Acetyltransferases, O-Acetyltransferases, and N,O-Acetyltransferases: Enzymology and Bioactivation.
    M.W. Anders and W. Dekant, Aminoacylases.
    J.L. Hoffman, Bioactivation by S-Adenosylation, S-Methylation, or N-Methylation.
    S. Vamvakas and M.W. Anders, Bioconversion of Prodrugs by Conjugate-Processing Enzymes.
    Subject Index.

Product details

  • No. of pages: 519
  • Language: English
  • Copyright: © Academic Press 1994
  • Published: May 16, 1994
  • Imprint: Academic Press
  • eBook ISBN: 9780080581187

About the Serial Editors

J. August

Affiliations and Expertise

John Hopkins University; Department of Pharmacology, Baltimore, Maryland, U.S.A.

Ferid Murad

Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held several distinguished positions, including Acting Chairman in the Department of Medicine and Acting Division Chief, Division of Respiratory Medicine at Stanford University. He currently is CEO and President of Molecular Geriatrics Corporation in Lake Bluff, Illinois. Dr. Murad is married and has five children.

Affiliations and Expertise

University of Texas Medical School, Houston, U.S.A.

About the Serial Volume Editors

M. Anders

Affiliations and Expertise

University of Rochester; Department of Pharmacology, New York, U.S.A.

Wolfgang Dekant

Affiliations and Expertise

Universitat Wurzburg

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