Congress Proceedings
Radiation Research: A Twentieth-Century Perspective
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Table of Contents
Preface
Editors Acknowledgments
Acknowledgments
Officers
Program Committee
Award Lectures 1
Ontario Cancer Treatment and Research Foundation Richards Award
Potential for Proton Beams in Clinical Radiation Oncology
North American Hyperthermia Group J. Eugene Robinson Award
An Engineer Looks at Hyperthermia
International Association of Radiation Research Henry S. Kaplan Distinguished Science Award
From Bedside to Bench and Back
Radiation Chemistry
Congress Lecture
Electron Transfer in Biology. Some General Aspects, and Specific Contributions by Radiation Chemistry
Congress Lecture
Dynamics of Localization and Solvation of Electrons in Finite Clusters and Bulk Media
Congress Lecture
Ultrafast Dynamics of Electron Solvation
SYmposium: Early Radiation Chemistry: Femtoseconds to Nanoseconds
Concept Design of Electron Femtosecond Pulse Radiolysis
Studies of Ion Solvation Using Pulse Radiolysis
Geminate Ion Recombination in Neat Alkane Liquids Studied by Picosecond Pulse Radiolysis
Symposium: Electron Transfer in Proteins and Peptides
Protein to Protein Electron Transfer
Effects of Structure on Long-Range Electron Transfer in Peptides
Applications of Pulse Radiolysis to Studies on Metalloproteins
Symposium: Radiation Chemistry at the DNA/Water Interface
Charge Migration in Hydrated DNA
Role of Hydration in Influencing Radiation-Induced Damage of DNA at Early Times
Mechanisms of Radiation-Induced Damage of DNA in the Presence of Oxygen and Thiols
Symposium: Radiation Chemistry of Microheterogeneous Media
Radiation-Induced Processes in Microheterogeneous Media
Charge Effects on Photoionization Near Vesicle Interfaces
Radiation-Induced Growth of Micro Crystallites
Electrical Double Layer Effects on Electron Transfer Reactions at Colloidal Metal Oxide-Aqueous Solution Interfaces
DNA and Chromosomal Damage and Repair
Congress Lecture
DNA Repair-Deficient Human Diseases
Symposium: Molecular Biology of the Interphase Nucleus
Chromatin Structure and Gene Expression in Drosophila
Chromatin and Nuclear Structural Factors Which Modify the Radiosensitivity of DNA
Genomic Heterogeneity of UV-Induced Repair: Relationship to Higher-Order Chromatin Structure and Transcriptional Activity
Subnuclear Structure in Radiation and Heat Response
Symposium: Evaluation of New Approaches Used to Measure Radiation Damage in Humans
Molecular Cytogenetic Approaches to Biological Dosimetry and to Characterization of Specific Genetic Changes in Human Tumors
Biodosimetry of Ionizing Radiation in Humans Using the Glycophorin A Genotoxicity Assay
Evaluation of Four Somatic Mutation Assays as Biological Dosimeter in Humans
Experience with the "Cytochalasin-B Method" for Quantifying Radiation-Induced Micronuclei in Human Lymphocytes
Symposium: Mechanisms of Formation of Radiation-Induced Chromosomal Aberrations
Breaks and Intrachanges
The Potential Role of Chromatin Organization in the Induction and Repair of Chromosome Aberrations
The Role of Unrepaired Lesions in the Fixation of Chromosome Damage
Restriction Enzyme-Induced DNA Double-Strand Breaks as a Model to Study the Mechanisms of Chromosomal Aberration Formation
Damage Selectivity in Chromosomes
Congress Lecture
Mapping the Organizational and Functional Topography of the Cell Nucleus
Symposium: Genes Controlling DNA Repair
Genes Controlling DNA Repair
Molecular Analysis of Group A Xeroderma Pigmentosum Gene and Its Product
Genes Controlling Nucleotide Excision Repair in Mammalian Cells
Conservation of Structure and Function of DNA Repair Genes between Yeast and Human
Multiplicity of Mammalian DNA Ligases
Recent Progress in Characterizing Human DNA Repair Genes Cloned Using Rodent Cell Lines
Symposium: Enzymology of DNA Repair
Structure-Function Analyses of Uvr Proteins Catalyzing Nucleotide Excision
Base Excision Repair of Radiation Damage in Escherichia coli
Role of Human DNA Deoxyribophosphodiesterase in Excision Repair of Ionising Radiation-Induced DNA Damage
Congress Lecture
Induction of Gene Expression by Radiation
Congress Lecture
Carcinogenesis and DNA Repair in Transgenic Mice
Radiation Effects on Development
Symposium: Radiation Effects on Development
Effects after Irradiation during the Preimplantation Period
Experimental Studies on Brain Development after Prenatal Irradiation
Effects on the Development of the Human Brain after Prenatal Radiation
Uptake and Distribution of Radionuclides in the Embryo and Fetus—Implications for Dosimetry
Radiation Mutagenesis and Oncogenesis
Symposium: Cellular and Molecular Mechanisms of Radiation-Induced Mutagenesis
Mutagenesis of E. coli by Ionizing Radiation
Molecular and Cellular Basis of Radiation-Induced Base Substitutions and Genome Rearrangements in Cultured Mammalian Cells
In Vivo Mutations in Human T-Cells after Ionizing Radiation Exposures
Symposium: Mechanisms in Cellular Neoplastic Transformation
Cancer and Aging in Rodents versus Humans
Multistep Nature of Radiation-Induced Neoplastic Transformation in Syrian Golden Hamster Embryo Cells
Tumor Suppressor Gene Inactivation and Radiation-Induced Neoplastic Transformation In Vitro: Model Studies Using Human Hybrid Cells
Symposium: Radiation Carcinogenesis In Vivo: Cellular and Molecular Mechanisms
Cellular and Molecular Events Underlying Radiation and Chemical Carcinogenesis of the Rat Mammary Gland
ras Oncogene Activation in Gamma- and Neutron-Radiation-Induced Murine Thymic Lymphomas
Molecular Aspects of Ionizing Radiation-Induced Skin Carcinogenesis
Alteration of the Retinoblastoma Gene Locus in Radium-Exposed Individuals
Congress Lecture
Molecular and Cell Biology of Lung Cancer
Symposium: Radiation, Oncogenes and Human Cancer
Gene Induction by Ionizing Radiation
Oncogene Activation during Radiation Transformation In Vitro
Oncogene Activation in Ultraviolet-Induced Skin Tumors from Normal Individuals and Xeroderma Pigmentosum Patients
Mechanism of Radioresistance in Oncogene Transfected Cell Lines
Congress Lecture
Genetics of Tumor Progression
Radiation Exposure, Dosimetry and Risks
Symposium: Energy Deposition in Sub Microscopic Volumes
Techniques for Measurement of Energy Deposition in Nanometer Volumes
Variance-Covariance: A Practical Method for Microdosimetry in Submicroscopic Volumes
Energy Deposition in Sub-microscopic Volumes
Restricted LET Determines the Yield of Intratrack Pairwise Lesion Interaction
Energy Transfer Mechanisms in DNA: Relationship to Energy Deposition in Sub-microscopic Volumes
Symposium: Radioecology
Estimation of Dose to Human Tissues from Ingestion of Foods Exposed to Fallout from Nuclear Weapons Tests in Nevada
Radioecological and Dosimetric Models Used for Retrospective Predictive Assessment of Human Exposure after the Chernobyl Accident
Agricultural Countermeasures Taken in the Chernobyl Region and Evaluation of the Results
Validation of Radioecological Models Using Chernobyl Data
Radioecological Measurements after the Goiania Accident
Position of Radioecology in View of Radiation Protection: Facts and Trends
Symposium: Hazards of Radon
An Overview of the Radon Problem: Does In Vitro Research Have a Role to Play?
A Review of Experimental Animal Radon Health Effects Data
Symposium: Radiation Effects in Space: Humans and Chips
Radiation Effects in Space: Research Needs
Human Exposure to Galactic Cosmic Rays in Space
Heavy Ion Radiobiology of the Nematode Caenorhabditis elegans
Problems of Risk Estimation on the Basis of Accelerator Experiments
Radiation Risk in Space: Implications of In Vitro Heavy Ion Mutation Experiments
Potential Enhanced Risk for Space-Station Astronauts Exposed to Highly Fractionated Doses of Fast Protons
Single-Event Upsets in Microelectronics
Radiation Safety during Soviet Cosmonauts' Flights. Principles and Realization
Congress Lecture
Radiation Protection: The Basis of New Recommendations on Limits of Exposure
Radiotherapy
Congress Lecture
Radiosurgery in the Management of Intracranial Lesions: A Radiation Oncology Perspective
Congress Lecture
Clinical Experience with a Fully Three-Dimensional Treatment Planning System
Symposium: Altered Fractionation in Radiation Therapy
Introduction to Modified Fractionation
Time Factor in Radiotherapy: Repopulation and Repair Kinetics
Concomitant Boost Radiotherapy in the Treatment of Head and Neck Cancers
Continuous, Hyperfractionated, Accelerated Radiation Therapy (CHART)
RTOG Altered Fractionation Trials
Symposium: Sensitizers in Clinical Trials
The Danish Head and Neck Cancer Study Group (DAHANCA) Randomized Trials with Hypoxie Radiosensitizers in Carcinoma of the Larynx and Pharynx
Intratumoral Strategies for Clinical Radiosensitization
Radiotherapy, Carcinoma of the Cervix and the Radiosensitizer Ro 03-8799 (Pimonidazole)
European Etanidazole Phase III Trial (Progress Report)
Clinical Trials of Etanidazole (SR 2508): RTOG and Joint Center for Radiation Therapy Trials
Rationale for and Experience with Clinical Trials of Halogenated Pyrimidines in Malignant Gliomas: The UCSF/NCOG Experience
S-Phase Specific Radiosensitizers: New Experimental and Clinical Approaches to Overcome Tumor Cell Repopulation
Symposium: High-LET Radiotherapy
An Evaluation of Fast-Neutron Therapy
Boron Neutron Capture Therapy: A Means of Increasing the Effectiveness of Fast Neutron Radiotherapy
Boron Neutron Capture Therapy of Cancer: New Developments
The European High-LET Research Programs in 1991
High-LET Charged Particle Radiotherapy
High-LET Charged-Particle Radiotherapy Research Facility in Japan
Symposium: Radiolabeled Antibodies in Cancer Therapy
Strategies to Improve the Efficacy of Radioimmunotherapy: Radiobiological and Dosimetric Considerations
External-Beam and Radioimmunotherapy Dosimetry Comparison of Colorectal Xenografts
Radioimmunotherapy Studies in Breast Cancer
Symposium: Photodynamic Therapy
Second-Generation Photosensitizers for Photodynamic Therapy of Cancer
Molecular and Biochemical Analysis of Photooxidative Stress Induced by Photodynamic Therapy
Optical and Photobiological Dosimetry for Photodynamic Therapy of Solid Tumors
Approaches to Improve Photochemotherapy of Cancer
Photodynamic Therapy: Current Status and Directions for Future Research
Congress Lecture
Is Selection the Key to Success in Combining Radiotherapy and Chemotherapy?
Symposium: Validity of in Vitro Assays of Cell Survival in Predicting Outcome of Radiotherapy
In Vitro Radiosensitivity of Tumor Cells and Local Tumor Control by Radiotherapy
In Vitro Radiosensitivity and Calculated Cell Growth Fraction in Primary Cultures from Head and Neck Cancers and Cervical Carcinomas: Preliminary Correlations with Treatment Outcome
Surviving Fraction at 2 Gy versus Control of Human Cervical Carcinoma—Update of the Manchester Study
Radiosensitivity Testing in Gynecological Tumors and Malignant Gliomas
Evaluation of Different In Vitro Assays of Inherent Sensitivity as Predictors of Radiotherapy Response
The Biology of Radiation Responses
Congress Lecture
Tumor Hypoxia, Its Clinical Detection and Relevance
Symposium: Radiobiology of Human Tumor Cells
The Nature of Differences in Radiosensitivity among Human Tumor Cells
Are Human Melanoma Cells More Radioresistant In Vivo Than In Vitro!
Prospects for Modifying the Radiosensitivity of Oxic Tumor Cells
Where Do Radioresistant Cells Come From?
Variation in Radiosensitivity among Human Tumors and Human Fibroblasts
Symposium: Physiological Characteristics of Tumor Microenvironments
Microregional Heterogeneity in Tumour Perfusion
Interstitial Hypertension in Experimental and Human Tumors: Etiology and Therapeutic Implications
Oxygenation and Bioenergetic Status of Human Tumors
The pH of Human Tumors: Facts and Problems
Symposium: New Drugs Exploiting Tumor Physiology
Prospect for Improved Nitroazole Radiosensitizers
Preclinical Studies with New Mitomycin Analogs
DNA-Binding Nitroheterocycles as Hypoxia-Selective Cytotoxins
Bioreductive Drugs—Dual Function Agents and Related Compounds
Fractionation Increases the Antitumor Effect of Adding a Hypoxie Cytotoxin to Irradiation
Prospects for Drugs Exploiting Lower Tumor pH
Symposium: Growth Factors/Cytokines in Radiation Responses
The Role of TGF-ßl in the Pathogenesis of Radiation-Induced Hepatic Fibrosis
Regulatory Polypeptide Factors, Signal Transduction and Radiation Response
Role of Cytokines in Innate and LPS-Enhanced Radioresistance
Therapeutic Potential of Cytokines and Peptides in Irradiation-Induced Myelosuppression
Imaging
Congress Lecture
Metabolic Imaging of Tumors Using Emission Tomography and Nuclear Magnetic Resonance
Congress Lecture
Digital Imaging Techniques in Biology
Symposium: Synchrotoron Radiation Microimaging in Biology
Progress and Prospects in X-Ray Microscopy Imaging for Biological Sciences
Non-Ionizing Radiation
Congress Lecture
Interactions of Extremely-Low-Frequency Electromagnetic Fields with Humans
Congress Lecture
Biophysics and Biological Effects of Ultrasound
Hyperthermia
Congress Lecture
Hyperthermia 1991: A Critical Review
Congress Lecture
Aspects of Non-Invasive Thermometry
Symposium: Superficial and Deep-Heating Techniques
Superficial Hyperthermia with Microwaves
Electromagnetic Techniques for Bulky and Deep-Seated Tumors
Interstitial Hyperthermia—Evolving Technologies
Symposium: Site-Specific Clinical Trials for Thermal Radiotherapy
The Current Clinical Trials in the Thermoradiotherapy of Head and Neck Tumors
The Role of Hyperthermia in the Treatment of Local-Regional Recurrences of Breast Cancer: Influence of Pretreatment and Treatment Factors
Hyperthermia of Brain Tumors
Site-Specific Clinical Trials Using Deep Hyperthermia
Thermoradiotherapy in the USSR
Symposium: Predictors for Human Tumor Response to Hyperthermia
Thermotolerance in Human Subjects: Clinical Significance and Methods of Determination
Physiological, Glycolytic, and Cytogenetic Parameters as Predictors for Heat Treatment
Prognostic Value of Tumor Tissue pH for Tumor Response to Hyperthermia
MRI and MRS for Prognostic Evaluation and Therapy Monitoring in Soft Tissue Sarcomas Treated with Hyperthermia and Radiotherapy
Congress Lecture
Function and Regulation of the Universally Conserved Heat-Shock
Symposium: Heat-Shock Response, Regulation and Functions of HSP
Regulation and Function of hsp27 during Hypothermia
Regulation and Function of Collagen-Binding Heat-Shock Protein: hsp-47
The Expression and Function of hsp-70
The 110 kDa Heat-Shock Protein and the 170 kDa Glucose Regulated Protein
Congress Lecture
Protein Denaturation: Its Role in Thermal Killing
Symposium: Biology of Hyperthermia and Its Interaction with Radiation and Anti-Cancer Agents (In Vitro)
Hyperthermia and Radiation: Mechanisms of Interaction
Cytotoxicity In Vitro and In Vivo/In Vitro of Cw-diamminedichloroplatinum(II) (CDDP), Etanidazole, and SR-4233 under Various Conditions of pH, Oxygénation and Temperature ± Radiation
Proteins, Thermotolerance, and Heat-Induced Cell Death
Symposium: Biology of Hyperthermia: Interaction with Radiation and Drugs (In Vivo)
Radiobiological Approaches to Enhancement of Thermoradiotherapy Efficacy
Studies on Combined Treatment with X Rays, Hyperthermia and Hypoxie Cell Sensitizers on Tumors
Preclinical and Clinical Results with Chemotherapy/Hyperthermia/Radiation
Interaction of Hyperthermia and Radiation in Solid Tumors In Vivo
Indexes
Author Index
Subject Index
Product details
- No. of pages: 1086
- Language: English
- Copyright: © Academic Press 1992
- Published: January 1, 1992
- Imprint: Academic Press
- eBook ISBN: 9781483264172
About the Editors
William C. Dewey
Martha Edington
R. J. Michael Fry
Department of Biochemistry, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, POB 9649, Bat Galim, Haifa, 31096, Israel
Affiliations and Expertise
Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel