Congress Proceedings

Congress Proceedings

Radiation Research: A Twentieth-Century Perspective

1st Edition - January 1, 1992

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  • Editors: William C. Dewey, Martha Edington, R. J. Michael Fry
  • eBook ISBN: 9781483264172

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Table of Contents

  • Preface

    Editors Acknowledgments



    Program Committee

    Award Lectures 1

    Ontario Cancer Treatment and Research Foundation Richards Award

    Potential for Proton Beams in Clinical Radiation Oncology

    North American Hyperthermia Group J. Eugene Robinson Award

    An Engineer Looks at Hyperthermia

    International Association of Radiation Research Henry S. Kaplan Distinguished Science Award

    From Bedside to Bench and Back

    Radiation Chemistry

    Congress Lecture

    Electron Transfer in Biology. Some General Aspects, and Specific Contributions by Radiation Chemistry

    Congress Lecture

    Dynamics of Localization and Solvation of Electrons in Finite Clusters and Bulk Media

    Congress Lecture

    Ultrafast Dynamics of Electron Solvation

    SYmposium: Early Radiation Chemistry: Femtoseconds to Nanoseconds

    Concept Design of Electron Femtosecond Pulse Radiolysis

    Studies of Ion Solvation Using Pulse Radiolysis

    Geminate Ion Recombination in Neat Alkane Liquids Studied by Picosecond Pulse Radiolysis

    Symposium: Electron Transfer in Proteins and Peptides

    Protein to Protein Electron Transfer

    Effects of Structure on Long-Range Electron Transfer in Peptides

    Applications of Pulse Radiolysis to Studies on Metalloproteins

    Symposium: Radiation Chemistry at the DNA/Water Interface

    Charge Migration in Hydrated DNA

    Role of Hydration in Influencing Radiation-Induced Damage of DNA at Early Times

    Mechanisms of Radiation-Induced Damage of DNA in the Presence of Oxygen and Thiols

    Symposium: Radiation Chemistry of Microheterogeneous Media

    Radiation-Induced Processes in Microheterogeneous Media

    Charge Effects on Photoionization Near Vesicle Interfaces

    Radiation-Induced Growth of Micro Crystallites

    Electrical Double Layer Effects on Electron Transfer Reactions at Colloidal Metal Oxide-Aqueous Solution Interfaces

    DNA and Chromosomal Damage and Repair

    Congress Lecture

    DNA Repair-Deficient Human Diseases

    Symposium: Molecular Biology of the Interphase Nucleus

    Chromatin Structure and Gene Expression in Drosophila

    Chromatin and Nuclear Structural Factors Which Modify the Radiosensitivity of DNA

    Genomic Heterogeneity of UV-Induced Repair: Relationship to Higher-Order Chromatin Structure and Transcriptional Activity

    Subnuclear Structure in Radiation and Heat Response

    Symposium: Evaluation of New Approaches Used to Measure Radiation Damage in Humans

    Molecular Cytogenetic Approaches to Biological Dosimetry and to Characterization of Specific Genetic Changes in Human Tumors

    Biodosimetry of Ionizing Radiation in Humans Using the Glycophorin A Genotoxicity Assay

    Evaluation of Four Somatic Mutation Assays as Biological Dosimeter in Humans

    Experience with the "Cytochalasin-B Method" for Quantifying Radiation-Induced Micronuclei in Human Lymphocytes

    Symposium: Mechanisms of Formation of Radiation-Induced Chromosomal Aberrations

    Breaks and Intrachanges

    The Potential Role of Chromatin Organization in the Induction and Repair of Chromosome Aberrations

    The Role of Unrepaired Lesions in the Fixation of Chromosome Damage

    Restriction Enzyme-Induced DNA Double-Strand Breaks as a Model to Study the Mechanisms of Chromosomal Aberration Formation

    Damage Selectivity in Chromosomes

    Congress Lecture

    Mapping the Organizational and Functional Topography of the Cell Nucleus

    Symposium: Genes Controlling DNA Repair

    Genes Controlling DNA Repair

    Molecular Analysis of Group A Xeroderma Pigmentosum Gene and Its Product

    Genes Controlling Nucleotide Excision Repair in Mammalian Cells

    Conservation of Structure and Function of DNA Repair Genes between Yeast and Human

    Multiplicity of Mammalian DNA Ligases

    Recent Progress in Characterizing Human DNA Repair Genes Cloned Using Rodent Cell Lines

    Symposium: Enzymology of DNA Repair

    Structure-Function Analyses of Uvr Proteins Catalyzing Nucleotide Excision

    Base Excision Repair of Radiation Damage in Escherichia coli

    Role of Human DNA Deoxyribophosphodiesterase in Excision Repair of Ionising Radiation-Induced DNA Damage

    Congress Lecture

    Induction of Gene Expression by Radiation

    Congress Lecture

    Carcinogenesis and DNA Repair in Transgenic Mice

    Radiation Effects on Development

    Symposium: Radiation Effects on Development

    Effects after Irradiation during the Preimplantation Period

    Experimental Studies on Brain Development after Prenatal Irradiation

    Effects on the Development of the Human Brain after Prenatal Radiation

    Uptake and Distribution of Radionuclides in the Embryo and Fetus—Implications for Dosimetry

    Radiation Mutagenesis and Oncogenesis

    Symposium: Cellular and Molecular Mechanisms of Radiation-Induced Mutagenesis

    Mutagenesis of E. coli by Ionizing Radiation

    Molecular and Cellular Basis of Radiation-Induced Base Substitutions and Genome Rearrangements in Cultured Mammalian Cells

    In Vivo Mutations in Human T-Cells after Ionizing Radiation Exposures

    Symposium: Mechanisms in Cellular Neoplastic Transformation

    Cancer and Aging in Rodents versus Humans

    Multistep Nature of Radiation-Induced Neoplastic Transformation in Syrian Golden Hamster Embryo Cells

    Tumor Suppressor Gene Inactivation and Radiation-Induced Neoplastic Transformation In Vitro: Model Studies Using Human Hybrid Cells

    Symposium: Radiation Carcinogenesis In Vivo: Cellular and Molecular Mechanisms

    Cellular and Molecular Events Underlying Radiation and Chemical Carcinogenesis of the Rat Mammary Gland

    ras Oncogene Activation in Gamma- and Neutron-Radiation-Induced Murine Thymic Lymphomas

    Molecular Aspects of Ionizing Radiation-Induced Skin Carcinogenesis

    Alteration of the Retinoblastoma Gene Locus in Radium-Exposed Individuals

    Congress Lecture

    Molecular and Cell Biology of Lung Cancer

    Symposium: Radiation, Oncogenes and Human Cancer

    Gene Induction by Ionizing Radiation

    Oncogene Activation during Radiation Transformation In Vitro

    Oncogene Activation in Ultraviolet-Induced Skin Tumors from Normal Individuals and Xeroderma Pigmentosum Patients

    Mechanism of Radioresistance in Oncogene Transfected Cell Lines

    Congress Lecture

    Genetics of Tumor Progression

    Radiation Exposure, Dosimetry and Risks

    Symposium: Energy Deposition in Sub Microscopic Volumes

    Techniques for Measurement of Energy Deposition in Nanometer Volumes

    Variance-Covariance: A Practical Method for Microdosimetry in Submicroscopic Volumes

    Energy Deposition in Sub-microscopic Volumes

    Restricted LET Determines the Yield of Intratrack Pairwise Lesion Interaction

    Energy Transfer Mechanisms in DNA: Relationship to Energy Deposition in Sub-microscopic Volumes

    Symposium: Radioecology

    Estimation of Dose to Human Tissues from Ingestion of Foods Exposed to Fallout from Nuclear Weapons Tests in Nevada

    Radioecological and Dosimetric Models Used for Retrospective Predictive Assessment of Human Exposure after the Chernobyl Accident

    Agricultural Countermeasures Taken in the Chernobyl Region and Evaluation of the Results

    Validation of Radioecological Models Using Chernobyl Data

    Radioecological Measurements after the Goiania Accident

    Position of Radioecology in View of Radiation Protection: Facts and Trends

    Symposium: Hazards of Radon

    An Overview of the Radon Problem: Does In Vitro Research Have a Role to Play?

    A Review of Experimental Animal Radon Health Effects Data

    Symposium: Radiation Effects in Space: Humans and Chips

    Radiation Effects in Space: Research Needs

    Human Exposure to Galactic Cosmic Rays in Space

    Heavy Ion Radiobiology of the Nematode Caenorhabditis elegans

    Problems of Risk Estimation on the Basis of Accelerator Experiments

    Radiation Risk in Space: Implications of In Vitro Heavy Ion Mutation Experiments

    Potential Enhanced Risk for Space-Station Astronauts Exposed to Highly Fractionated Doses of Fast Protons

    Single-Event Upsets in Microelectronics

    Radiation Safety during Soviet Cosmonauts' Flights. Principles and Realization

    Congress Lecture

    Radiation Protection: The Basis of New Recommendations on Limits of Exposure


    Congress Lecture

    Radiosurgery in the Management of Intracranial Lesions: A Radiation Oncology Perspective

    Congress Lecture

    Clinical Experience with a Fully Three-Dimensional Treatment Planning System

    Symposium: Altered Fractionation in Radiation Therapy

    Introduction to Modified Fractionation

    Time Factor in Radiotherapy: Repopulation and Repair Kinetics

    Concomitant Boost Radiotherapy in the Treatment of Head and Neck Cancers

    Continuous, Hyperfractionated, Accelerated Radiation Therapy (CHART)

    RTOG Altered Fractionation Trials

    Symposium: Sensitizers in Clinical Trials

    The Danish Head and Neck Cancer Study Group (DAHANCA) Randomized Trials with Hypoxie Radiosensitizers in Carcinoma of the Larynx and Pharynx

    Intratumoral Strategies for Clinical Radiosensitization

    Radiotherapy, Carcinoma of the Cervix and the Radiosensitizer Ro 03-8799 (Pimonidazole)

    European Etanidazole Phase III Trial (Progress Report)

    Clinical Trials of Etanidazole (SR 2508): RTOG and Joint Center for Radiation Therapy Trials

    Rationale for and Experience with Clinical Trials of Halogenated Pyrimidines in Malignant Gliomas: The UCSF/NCOG Experience

    S-Phase Specific Radiosensitizers: New Experimental and Clinical Approaches to Overcome Tumor Cell Repopulation

    Symposium: High-LET Radiotherapy

    An Evaluation of Fast-Neutron Therapy

    Boron Neutron Capture Therapy: A Means of Increasing the Effectiveness of Fast Neutron Radiotherapy

    Boron Neutron Capture Therapy of Cancer: New Developments

    The European High-LET Research Programs in 1991

    High-LET Charged Particle Radiotherapy

    High-LET Charged-Particle Radiotherapy Research Facility in Japan

    Symposium: Radiolabeled Antibodies in Cancer Therapy

    Strategies to Improve the Efficacy of Radioimmunotherapy: Radiobiological and Dosimetric Considerations

    External-Beam and Radioimmunotherapy Dosimetry Comparison of Colorectal Xenografts

    Radioimmunotherapy Studies in Breast Cancer

    Symposium: Photodynamic Therapy

    Second-Generation Photosensitizers for Photodynamic Therapy of Cancer

    Molecular and Biochemical Analysis of Photooxidative Stress Induced by Photodynamic Therapy

    Optical and Photobiological Dosimetry for Photodynamic Therapy of Solid Tumors

    Approaches to Improve Photochemotherapy of Cancer

    Photodynamic Therapy: Current Status and Directions for Future Research

    Congress Lecture

    Is Selection the Key to Success in Combining Radiotherapy and Chemotherapy?

    Symposium: Validity of in Vitro Assays of Cell Survival in Predicting Outcome of Radiotherapy

    In Vitro Radiosensitivity of Tumor Cells and Local Tumor Control by Radiotherapy

    In Vitro Radiosensitivity and Calculated Cell Growth Fraction in Primary Cultures from Head and Neck Cancers and Cervical Carcinomas: Preliminary Correlations with Treatment Outcome

    Surviving Fraction at 2 Gy versus Control of Human Cervical Carcinoma—Update of the Manchester Study

    Radiosensitivity Testing in Gynecological Tumors and Malignant Gliomas

    Evaluation of Different In Vitro Assays of Inherent Sensitivity as Predictors of Radiotherapy Response

    The Biology of Radiation Responses

    Congress Lecture

    Tumor Hypoxia, Its Clinical Detection and Relevance

    Symposium: Radiobiology of Human Tumor Cells

    The Nature of Differences in Radiosensitivity among Human Tumor Cells

    Are Human Melanoma Cells More Radioresistant In Vivo Than In Vitro!

    Prospects for Modifying the Radiosensitivity of Oxic Tumor Cells

    Where Do Radioresistant Cells Come From?

    Variation in Radiosensitivity among Human Tumors and Human Fibroblasts

    Symposium: Physiological Characteristics of Tumor Microenvironments

    Microregional Heterogeneity in Tumour Perfusion

    Interstitial Hypertension in Experimental and Human Tumors: Etiology and Therapeutic Implications

    Oxygenation and Bioenergetic Status of Human Tumors

    The pH of Human Tumors: Facts and Problems

    Symposium: New Drugs Exploiting Tumor Physiology

    Prospect for Improved Nitroazole Radiosensitizers

    Preclinical Studies with New Mitomycin Analogs

    DNA-Binding Nitroheterocycles as Hypoxia-Selective Cytotoxins

    Bioreductive Drugs—Dual Function Agents and Related Compounds

    Fractionation Increases the Antitumor Effect of Adding a Hypoxie Cytotoxin to Irradiation

    Prospects for Drugs Exploiting Lower Tumor pH

    Symposium: Growth Factors/Cytokines in Radiation Responses

    The Role of TGF-ßl in the Pathogenesis of Radiation-Induced Hepatic Fibrosis

    Regulatory Polypeptide Factors, Signal Transduction and Radiation Response

    Role of Cytokines in Innate and LPS-Enhanced Radioresistance

    Therapeutic Potential of Cytokines and Peptides in Irradiation-Induced Myelosuppression


    Congress Lecture

    Metabolic Imaging of Tumors Using Emission Tomography and Nuclear Magnetic Resonance

    Congress Lecture

    Digital Imaging Techniques in Biology

    Symposium: Synchrotoron Radiation Microimaging in Biology

    Progress and Prospects in X-Ray Microscopy Imaging for Biological Sciences

    Non-Ionizing Radiation

    Congress Lecture

    Interactions of Extremely-Low-Frequency Electromagnetic Fields with Humans

    Congress Lecture

    Biophysics and Biological Effects of Ultrasound


    Congress Lecture

    Hyperthermia 1991: A Critical Review

    Congress Lecture

    Aspects of Non-Invasive Thermometry

    Symposium: Superficial and Deep-Heating Techniques

    Superficial Hyperthermia with Microwaves

    Electromagnetic Techniques for Bulky and Deep-Seated Tumors

    Interstitial Hyperthermia—Evolving Technologies

    Symposium: Site-Specific Clinical Trials for Thermal Radiotherapy

    The Current Clinical Trials in the Thermoradiotherapy of Head and Neck Tumors

    The Role of Hyperthermia in the Treatment of Local-Regional Recurrences of Breast Cancer: Influence of Pretreatment and Treatment Factors

    Hyperthermia of Brain Tumors

    Site-Specific Clinical Trials Using Deep Hyperthermia

    Thermoradiotherapy in the USSR

    Symposium: Predictors for Human Tumor Response to Hyperthermia

    Thermotolerance in Human Subjects: Clinical Significance and Methods of Determination

    Physiological, Glycolytic, and Cytogenetic Parameters as Predictors for Heat Treatment

    Prognostic Value of Tumor Tissue pH for Tumor Response to Hyperthermia

    MRI and MRS for Prognostic Evaluation and Therapy Monitoring in Soft Tissue Sarcomas Treated with Hyperthermia and Radiotherapy

    Congress Lecture

    Function and Regulation of the Universally Conserved Heat-Shock

    Symposium: Heat-Shock Response, Regulation and Functions of HSP

    Regulation and Function of hsp27 during Hypothermia

    Regulation and Function of Collagen-Binding Heat-Shock Protein: hsp-47

    The Expression and Function of hsp-70

    The 110 kDa Heat-Shock Protein and the 170 kDa Glucose Regulated Protein

    Congress Lecture

    Protein Denaturation: Its Role in Thermal Killing

    Symposium: Biology of Hyperthermia and Its Interaction with Radiation and Anti-Cancer Agents (In Vitro)

    Hyperthermia and Radiation: Mechanisms of Interaction

    Cytotoxicity In Vitro and In Vivo/In Vitro of Cw-diamminedichloroplatinum(II) (CDDP), Etanidazole, and SR-4233 under Various Conditions of pH, Oxygénation and Temperature ± Radiation

    Proteins, Thermotolerance, and Heat-Induced Cell Death

    Symposium: Biology of Hyperthermia: Interaction with Radiation and Drugs (In Vivo)

    Radiobiological Approaches to Enhancement of Thermoradiotherapy Efficacy

    Studies on Combined Treatment with X Rays, Hyperthermia and Hypoxie Cell Sensitizers on Tumors

    Preclinical and Clinical Results with Chemotherapy/Hyperthermia/Radiation

    Interaction of Hyperthermia and Radiation in Solid Tumors In Vivo


    Author Index

    Subject Index

Product details

  • No. of pages: 1086
  • Language: English
  • Copyright: © Academic Press 1992
  • Published: January 1, 1992
  • Imprint: Academic Press
  • eBook ISBN: 9781483264172

About the Editors

William C. Dewey

Martha Edington

R. J. Michael Fry

Department of Biochemistry, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, POB 9649, Bat Galim, Haifa, 31096, Israel

Affiliations and Expertise

Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel

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