Conformation in Biology and Drug Design

Conformation in Biology and Drug Design

The Peptides: Analysis, Synthesis, Biology, Vol. 7

1st Edition - November 26, 1985

Write a review

  • Editors: Sidney Udenfriend, Johannes Meienhofer, Victor J. Hruby
  • eBook ISBN: 9781483218007

Purchase options

Purchase options
DRM-free (PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


The Peptides: Analysis, Synthesis, Biology, Volume 7: Conformation in Biology and Drug Design focuses on the analysis of peptides, emphasizing the use of physical methods in peptide conformational analysis and the relationship of conformational properties of peptides to biological properties. This book consists of nine chapters. Chapter 1 provides a brief overview of the perspective on the application of physical methods to peptide conformational analysis. The use of circular dichroism (CD) spectroscopy to examine the conformational properties of peptides in solution is elaborated in Chapter 2, while the use of fluorescence spectroscopy to examine the special relationships of aromatic side-chain groups to one another is discussed in Chapter 3. In Chapter 4, the use of various theoretical methods to calculate the conformations of peptides is described. The methods used to stimulate peptide conformations and dynamics are outlined in Chapter 5. The last four chapters examine various aspects of the use of nuclear magnetic resonance (NMR) in peptide conformational analysis. This volume is suitable for biologists, specialists, and researchers interested in peptides and proteins.

Table of Contents

  • Contributors


    Nomenclature and Abbreviations

    Chapter 1 A Perspective on the Application of Physical Methods to Peptide Conformational-Biological Activity Studies

    I Introduction

    II Some Biological Considerations

    III Historical Development of Peptide Conformational Studies in Solution

    IV Theoretical Methods for Examining Peptide Conformations

    V Application of Conformational and Dynamic Studies of Peptides to Their Biological Activities


    Chapter 2 Circular Dichroism of Peptides

    I Introduction

    II General Aspects of Peptide CD

    III Specific Systems


    Chapter 3 Application of Fluorescence Techniques in Studies of Peptide Conformations and Interactions

    I Introductory Remarks

    II Fluorophores in Peptides

    III Fluorescence Quantum Yield and Lifetime Measurements

    IV Fluorescence Polarization Studies

    V Measurement of Intramolecular Distances by Singlet-Singlet Resonance Energy Transfer Experiments

    VI Fluorescence Studies of Peptide Interactions with Macromolecular Systems

    VII Concluding Remarks


    Chapter 4 Theoretical Methods in the Analysis of Peptide Conformation

    I Introduction

    II Definitions and Conventions

    III Methodology

    IV Results


    Chapter 5 Theoretical Simulation of Conformation, Energetics, and Dynamics of Peptides

    I Introduction

    II Techniques and Methodology

    III Applications

    IV Summary and Future Directions


    Chapter 6 Paramagnetic Metal Ions as Nuclear Magnetic Resonance Probes of Peptide Conformation in Solution

    I Introduction

    II Paramagnetic Metal Ion-Induced Shifts and Relaxation Enhancements

    III Conclusions


    Chapter 7 Nuclear Magnetic Resonance Studies of Peptide-Macromolecule Interactions

    I Introduction

    II Nuclear Magnetic Resonance Techniques

    III Peptide-Protein Interaction

    IV Peptide-Lipid Interaction

    V Peptide-Nucleic Acid Interactions

    VI Conclusions and Prospects


    Chapter 8 Solid-State Nuclear Magnetic Resonance of Peptides

    I Introduction

    II Methods

    III Applications

    IV Prospects


    Chapter 9 Modern Nuclear Magnetic Resonance Spectroscopy of Peptides

    I Introduction

    II Conformational Homogeneity

    III General Strategy for Nuclear Magnetic Resonance Investigation of Peptides

    IV Assignment of Proton Nuclear Magnetic Resonance Signals

    V Heteronuclear Techniques

    VI Sequence Analysis

    VII Quantitative Evaluation of Nuclear Magnetic Resonance Spectra

    VIII Conclusions



Product details

  • No. of pages: 516
  • Language: English
  • Copyright: © Academic Press 1985
  • Published: November 26, 1985
  • Imprint: Academic Press
  • eBook ISBN: 9781483218007

About the Editors

Sidney Udenfriend

Johannes Meienhofer

Victor J. Hruby

Ratings and Reviews

Write a review

There are currently no reviews for "Conformation in Biology and Drug Design"