Conformation in Biology and Drug Design - 1st Edition - ISBN: 9780123042071, 9781483218007

Conformation in Biology and Drug Design

1st Edition

The Peptides: Analysis, Synthesis, Biology, Vol. 7

Editors: Sidney Udenfriend Johannes Meienhofer Victor J. Hruby
eBook ISBN: 9781483218007
Imprint: Academic Press
Published Date: 26th November 1985
Page Count: 516
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The Peptides: Analysis, Synthesis, Biology, Volume 7: Conformation in Biology and Drug Design focuses on the analysis of peptides, emphasizing the use of physical methods in peptide conformational analysis and the relationship of conformational properties of peptides to biological properties.

This book consists of nine chapters. Chapter 1 provides a brief overview of the perspective on the application of physical methods to peptide conformational analysis. The use of circular dichroism (CD) spectroscopy to examine the conformational properties of peptides in solution is elaborated in Chapter 2, while the use of fluorescence spectroscopy to examine the special relationships of aromatic side-chain groups to one another is discussed in Chapter 3. In Chapter 4, the use of various theoretical methods to calculate the conformations of peptides is described. The methods used to stimulate peptide conformations and dynamics are outlined in Chapter 5. The last four chapters examine various aspects of the use of nuclear magnetic resonance (NMR) in peptide conformational analysis.

This volume is suitable for biologists, specialists, and researchers interested in peptides and proteins.

Table of Contents



Nomenclature and Abbreviations

Chapter 1 A Perspective on the Application of Physical Methods to Peptide Conformational-Biological Activity Studies

I Introduction

II Some Biological Considerations

III Historical Development of Peptide Conformational Studies in Solution

IV Theoretical Methods for Examining Peptide Conformations

V Application of Conformational and Dynamic Studies of Peptides to Their Biological Activities


Chapter 2 Circular Dichroism of Peptides

I Introduction

II General Aspects of Peptide CD

III Specific Systems


Chapter 3 Application of Fluorescence Techniques in Studies of Peptide Conformations and Interactions

I Introductory Remarks

II Fluorophores in Peptides

III Fluorescence Quantum Yield and Lifetime Measurements

IV Fluorescence Polarization Studies

V Measurement of Intramolecular Distances by Singlet-Singlet Resonance Energy Transfer Experiments

VI Fluorescence Studies of Peptide Interactions with Macromolecular Systems

VII Concluding Remarks


Chapter 4 Theoretical Methods in the Analysis of Peptide Conformation

I Introduction

II Definitions and Conventions

III Methodology

IV Results


Chapter 5 Theoretical Simulation of Conformation, Energetics, and Dynamics of Peptides

I Introduction

II Techniques and Methodology

III Applications

IV Summary and Future Directions


Chapter 6 Paramagnetic Metal Ions as Nuclear Magnetic Resonance Probes of Peptide Conformation in Solution

I Introduction

II Paramagnetic Metal Ion-Induced Shifts and Relaxation Enhancements

III Conclusions


Chapter 7 Nuclear Magnetic Resonance Studies of Peptide-Macromolecule Interactions

I Introduction

II Nuclear Magnetic Resonance Techniques

III Peptide-Protein Interaction

IV Peptide-Lipid Interaction

V Peptide-Nucleic Acid Interactions

VI Conclusions and Prospects


Chapter 8 Solid-State Nuclear Magnetic Resonance of Peptides

I Introduction

II Methods

III Applications

IV Prospects


Chapter 9 Modern Nuclear Magnetic Resonance Spectroscopy of Peptides

I Introduction

II Conformational Homogeneity

III General Strategy for Nuclear Magnetic Resonance Investigation of Peptides

IV Assignment of Proton Nuclear Magnetic Resonance Signals

V Heteronuclear Techniques

VI Sequence Analysis

VII Quantitative Evaluation of Nuclear Magnetic Resonance Spectra

VIII Conclusions




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© Academic Press 1985
Academic Press
eBook ISBN:

About the Editor

Sidney Udenfriend

Johannes Meienhofer

Victor J. Hruby

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