Computer Methods for Macromolecular Sequence Analysis, Volume 266

1st Edition

Serial Volume Editors: Russell Doolittle
Editor-in-Chiefs: John Abelson Melvin Simon
Hardcover ISBN: 9780121821678
eBook ISBN: 9780080883793
Imprint: Academic Press
Published Date: 23rd May 1996
Page Count: 711


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Table of Contents

Databases and Resources: B. Shomer, R.A.L. Harper, and G.N. Cameron, Information Services of European Bioinformatics Institute. O. White and A.R. Kerlavage, TDB: New Databases for Biological Discovery. D.G.George, L.T. Hunt, and W.C. Barker, PIR-International Protein Sequence Database. W.C. Barker, F. Pfeiffer, and D.G. George, Superfamily Classification in PIR-International Protein Sequence Database. C.H. Wu, Gene Classification ArtificialNeural System. J.G. Henikoff and S. Henikoff, Blocks Database and Its Applications. R. Staden, Indexing and Using Sequence Databases. T. Etzold, A. Ulyanov, and P. Argos, SRS: Information Retrieval System for Molecular Biology Data Banks. Searching through Databases: T.L. Madden, R.L. Tatusov, and J. Zhang, Applications of Network BLAST Server. G.D. Schuler, J.A. Epstein, H. Ohkawa, and J.A. Kans, Entrez: Molecular Biology Database and Retrieval System. P. Bork and T.J. Gibson, Applying Motif and Profile Searches. L. Patthy, Consensus Approaches in Detection of Distant Homologies. M. Gribskov and S. Veretnik, Identification of Sequence Patterns with Profile Analysis. J.-M. Claverie, Effective Large-Scale Sequence Similarity Searches. W.R. Pearson, Effective Protein Sequence Comparison. E.C. Uberbacher, Y. Xu, and R.J. Mural, Discovering and Understanding Genes in Human DNA Sequence Using GRAIL. G. Pesole, M. Attimonelli, and C. Saccone, Linguistic Analysis of Nucleotide Sequences: Algorithms for Pattern Recognition and Analysis of Codon Strategy. E.V. Koonin, R.L. Tatusov, and K.E. Rudd, Protein Sequence Comparison at Genome Scale. T.-M. Yi and E.S. Lander, IterativeTemplate Refinement: Protein-Fold Prediction Using Iterative Search and Hybrid Sequence/Structure Templates. Multiple Alignment and Phylogenetic Trees:</STRON


The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 260 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences.

Key Features

@introbul:Key Features @bul:* Databases and resources

  • Searching through databases
  • Multiple alignment and phylogenetic trees
  • Secondary structure considerations
  • Three-dimensional considerations


Biochemists, molecular biologists, evolutionary biologists, geneticists, cell biologists, and biotechnologists.


No. of pages:
© Academic Press 1996
Academic Press
eBook ISBN:
Hardcover ISBN:


@from:Praise for the Volume @qu:"The individual sections of the book are nicely balanced and provide detailed background information as well as outlines of the application and use of many of the programs... Coverage of protein structural predictions is excellent and the individual algorithms are explained in sufficient detail... Large-scale sequence similarity comparisons, detection of distant homologies, and pattern recognition are covered. This section of the book should be particularly useful to new researchers in this area and serve as a reference to those actively involved in the field... The coverage [of the third section] is outstanding and should serve as a useful reference to individuals interested in multiple alignments and phylogenetic tress. The breadth of topics covered by this volume of Methods in Enzymology is outstanding and the book should become very popular among a variety of biological investigators." @source:--MARK A. BATZER, Louisiana State University Medical Center @from:Praise for the Series @qu:"The Methods in Enzymology series represents the gold-standard." @source:--NEUROSCIENCE @qu:"Incomparably useful." @source:--ANALYTICAL BIOCHEMISTRY @qu:"It is a true 'methods' series, including almost every detail from basic theory to sources of equipment and reagents, with timely documentation provided on each page." @source:--BIO/TECHNOLOGY @qu:"The series has been following the growing, changing and creation of new areas of science. It should be on the shelves of all libraries in the world as a whole collection." @source:--CHEMISTRY IN INDUSTRY @qu:"The appearance of another volume in that excellent series, Methods in Enzymology, is always a cause for appreciation for those who wish to successfully carry out a particular technique or prepare

About the Serial Volume Editors

Russell Doolittle Serial Volume Editor

Affiliations and Expertise

Center for Molecular Genetics, University of California at San Diego, La Jolla, U.S.A.

About the Editor-in-Chiefs

John Abelson Editor-in-Chief

Affiliations and Expertise

California Institute of Technology, Division of Biology, Pasadena, U.S.A.

Melvin Simon Editor-in-Chief

Affiliations and Expertise

The Salk Institute, La Jolla, CA, USA