Comprehensive Medicinal Chemistry II

1st Edition



  • Hugo Kubinyi
    • Print ISBN 9780080445168


    Reviews the important technologies used in each step of the drug discovery process; target search, target validation, informatics and databases, structural biology, screening, chemical technologies, and lead search and optimization. Chemists, medicinal chemists and biologists present clear examinations of each step to help scientists understand the underlying techniques, problems and solutions encountered in finding a drug target and methods used to test and improve their properties.

    Key Features

    * valuable content available from May 2009 as an individual volume
    * separate volumes will appeal to a wider chemistry, biochemistry and medicinal audience
    * priced for individual researcher as well as library purchase


    For students and researchers in chemistry, biochemistry, medicinal chemistry and pharmacology and scientists working in the pharmaceutical industries.

    Table of Contents

    Volume 3 Drug Discovery Technologies
    Target Search
    3.01 Genomics
    3.02 Proteomics
    3.03 Pharmacogenomics
    3.04 Biomarkers
    3.05 Microarrays
    3.06 Recombinant Deoxyribonucleic Acid and Protein Expression
    3.07 Chemical Biology
    Target Validation
    3.08 Genetically Engineered Animals
    3.09 Small Interfering Ribonucleic Acids
    3.10 Signaling Chains
    3.11 Orthogonal Ligand–Receptor Pairs
    Informatics and Databases
    3.12 Chemoinformatics
    3.13 Chemical Information Systems and Databases
    3.14 Bioactivity Databases
    3.15 Bioinformatics
    3.16 Gene and Protein Sequence Databases
    3.17 The Research Collaboratory for Structural Bioinformatics Protein Data Bank
    3.18 The Cambridge Crystallographic Database Structural Biology
    Structural Biology
    3.19 Protein Production for Three-Dimensional Structural Analysis
    3.20 Protein Crystallization
    3.21 Protein Crystallography
    3.22 Bio-Nuclear Magnetic Resonance
    3.23 Protein Three-Dimensional Structure Validation
    3.24 Problems of Protein Three-Dimensional Structures
    3.25 Structural Genomics
    3.26 Compound Storage and Management
    3.27 Optical Assays in Drug Discovery
    3.28 Fluorescence Screening Assays
    3.29 Cell-Based Screening Assays
    3.30 Small Animal Test Systems for Screening
    3.31 Imaging
    3.32 High-Throughput and High-Content Screening
    Chemical Technologies
    3.33 Combinatorial Chemistry
    3.34 Solution Phase Parallel Chemistry
    3.35 Polymer-Supported Reagents and Scavengers in Synthesis
    3.36 Microwave-Assisted Chemistry
    3.37 High-Throughput Purification
    Lead Search and Optimization
    3.38 Protein Crystallography in Drug Discovery
    3.39 Nuclear Magnetic Resonance in Drug Discovery
    3.40 Chemogenomics
    3.41 Fragment-Based Approaches
    3.42 Dynamic Ligand Assembly


    No. of pages:
    © 2007
    Elsevier Science
    Print ISBN:

    About the author

    Hugo Kubinyi

    Affiliations and Expertise

    University of Heidelberg, Heidelberg, Germany