Comprehensive Medicinal Chemistry II

1st Edition



  • Peter Kennewell
    • Print ISBN 9780080445144


    This volume provides and educative and authoriative discussions on the drug discovery and development process. It is divided into ten sections and starts with personal recollections on the history and evolution of the drug discovery process. To illustrate the end result of the drug discovery process, a large chapter reviews the major drug introductions over 1993-2003. Subsequent chapters examine the impact of genomic technologies, new sources of drugs and alternatives to animal testing. The next section reviews the roles of enterprise and pharamaceuticals companies, venture capitalists and academic-industrial relations in the drug discovery process. Social and ethical issues are reviewed in the context of assessing health demands in developed, developing countries and also in relation to smaller scale diseases (orphan drugs). Two chapters then review the bioethical and ethical issues facing the pharmaceutical industry. The volume concludes with reviews on funding and regulartion and how intellectual property rights and patents are protected. With such a wide variety of topics this volume will appeal to both scientists and non-scientists who need to understand how and why the pharmaceutical industry works.

    Key Features

    * valuable content available from May 2009 as an individual volume
    * provides a global overview of the drug discovery process


    For students and researchers in chemistry, biochemistry, medicinal chemistry and pharmacology and scientists working in the pharmaceutical industries

    Table of Contents

    Volume 1 Global Perspective
    Historical Perspective and Outlook
    1.01 Reflections of a Medicinal Chemist: Formative Years through Thirty-Seven Years Service in
    the Pharmaceutical Industry
    1.02 Drug Discovery: Historical Perspective, Current Status, and Outlook
    1.03 Major Drug Introductions
    The Impact of New Genomic Technologies
    1.04 Epigenetics
    1.05 Personalized Medicine
    1.06 Gene Therapy
    Sources of New Drugs
    1.07 Overview of Sources of New Drugs
    1.08 Natural Product Sources of Drugs: Plants, Microbes, Marine Organisms, and Animals
    1.09 Traditional Medicines
    1.10 Biological Macromolecules
    1.11 Nutraceuticals
    Animal Experimentation
    1.12 Alternatives to Animal Testing
    The Role of Industry
    1.13 The Role of Small- or Medium-Sized Enterprises in Drug Discovery
    1.14 The Role of the Pharmaceutical Industry
    1.15 The Role of the Venture Capitalist
    1.16 Industry–Academic Relationships
    Drug Discovery: Revolution, Decline?
    1.17 Is the Biotechnology Revolution a Myth?
    1.18 The Apparent Declining Efficiency of Drug Discovery
    Healthcare in the Social Context
    1.19 How Much is Enough or Too Little: Assessing Healthcare Demand in Developed Countries
    1.20 Health Demands in Developing Countries
    1.21 Orphan Drugs and Generics
    Ethical Issues
    1.22 Bioethical Issues in Medicinal Chemistry and Drug Treatment
    1.23 Ethical Issues and Challenges Facing the Pharmaceutical Industry
    Funding and Regulation of Research
    1.24 The Role of Government in Health Research
    1.25 Postmarketing Surveillance
    Intellectual Property
    1.26 Intellectual Property Rights and Patents


    No. of pages:
    © 2007
    Elsevier Science
    Print ISBN: