Key Features

  • Find comprehensive coverage of hypertension including pathogenesis, prevention, and treatment all in one practical volume.
  • See the complete systemic problems of hypertension at a glance with detailed, full-color illustrations of cellular and clinical manifestations.
  • Simplify navigating the complexities of hypertension using algorithms for clinical exam and diagnosis.
  • Get specific insight into prevention and treatment of hypertension in special populations.
  • Go global with a comprehensive section on worldwide guidelines and the application of clinical material to local standards of practice.

Table of Contents

SECTION 1 - EPIDEMIOLOGY

*Blood pressure in Westernized populations
*Low blood pressure populations, the impact of rural -urban migration
*Regional differences in blood pressure in developed countries
*Low blood pressure populations, the impact of rural -urban migration
*Fetal influences on blood pressure: the Barker hypothesis
*Blood pressure and the risks of cardiovascular disease and stroke

SECTION 2 - PATHOGENESIS OF HYPERTENSION - HEMODYNAMICS AND VASCULAR MECHANISMS

*Haemodynamics of essential hypertension
*Genetic models of hypertension
*Experimental models of hypertension
*Left ventricular physiology in hypertension
*The arterial system in human hypertension
*Resistance vessels in hypertension
*Endothelial function
*Vascular growth, angiogenesis and hypertension
*Vascular smooth muscle
*Cell membranes - vascular smooth muscle action transport - vascular smooth muscle regulation by calcium magnesium and potassium
*Coagulation and platelet abnormalities
*Cytokines and inflammation

SECTION 3 - PATHOGENESIS OF HYPERTENSION - RENAL AND NEUROHUMORAL MECHANISMS

*Role of the kidney
*Autonomic control and hemodynamics of hypertension, baroreceptor function and reflexes
*Central nervous control of blood pressure
*The Renin-Angiotensin System
*Aldosterone and other adrenal steroids
*The endothelins
*Nitric oxide
*Reactive oxygen species and oxidative stress
*The natriuretic peptides
*Other peptide and related systems
*Other peptide and related systems
*Eicosanoids
*The kallikrein-kinin systems
*Sex steroids - estrogens and testosterone

SECTION 4 - PATHOGENESIS OF HYPERTENSION - GENETICS AND LIFESTYLE

*Genetic approaches to hypertension: relevance to human hypertension
*Monogenic forms of human hypertension
*Potential role of gene th

Details

No. of pages:
1248
Language:
English
Copyright:
© 2007
Published:
Imprint:
Mosby
eBook ISBN:
9780323070676
Print ISBN:
9780323039611

About the authors

Gregory Lip

Affiliations and Expertise

Consultant Cardiologist, University Department of Medicine, City Hospital Birmingham, UK

John Hall

Affiliations and Expertise

Arthur C. Guyton Professor and Chair, Department of Physiology and Biophysics, Director, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, Mississippi