Comprehensive Heterocyclic Chemistry IV

Comprehensive Heterocyclic Chemistry IV

1st Edition - November 23, 2021

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  • Editors-in-Chief: David Black, Janine Cossy, Christian Stevens
  • Hardcover ISBN: 9780128186558
  • eBook ISBN: 9780128186565

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Comprehensive Heterocyclic Chemistry IV provides a first point of entry for scientists interested in heterocyclic ring systems. Given the rapid expansion of publications in this field, this compilation of definitive reviews is especially important and invaluable. Written by leading scientists who have evaluated and summarized the most important data published over the last decade, this book is an invaluable addition to the reference library of anyone working with heterocyclic ring systems. Spanning 14 volumes, over 13,000 pages, and 240 chapters, this new edition builds on, and complements, the material in previous editions. This comprehensive resource is designed to be used both as a standalone resource and in conjunction with earlier works.

Key Features

  • Comprehensive – CHEC IV offers a comprehensive review of current heterocycles research and critical insight into the future direction of the field with an emphasis on useful and reliable synthesis and reactions, negating the need for individual searches in the primary literature and across various databases
  • Reputation – This 4th edition matches the impressive reputation of the previous editions as the go-to foundational reference in heterocyclic chemistry
  • Clearly structured - Meticulously organized, articles are split into 14 sections on key topics and clearly cross-referenced to allow students, researchers and professionals to find relevant information quickly and easily
  • Interdisciplinary - chapters written by academics and practitioners from various fields and regions ensures that the knowledge within is easily understood by and applicable to a large audience


Researchers in organic chemistry, including academic and industrial researchers, postgraduate students and laboratory assistants

Table of Contents

  • 1. Three-membered Heterocycles, and all Fused Systems with a Three-membered Heterocyclic Ring
    Matthias D'hooghe
    2. Four-membered Heterocycles, and all Fused Systems with a Four-membered Heterocyclic Ring
    Gwilherm Evano
    3. Five-membered Rings with One Heteroatom together with their Benzo and other Carbocyclic-fused Derivatives
    Henry Wong
    4. Five-membered rings with two heteroatoms and fused carbocyclic derivatives
    Alan Aitken
    5. Five-membered Rings: Triazoles, Oxadiazoles, Thiadiazoles and their Fused Carbocyclic Derivatives
    Panayiotis Koutentis
    6. Other Five-membered Rings with Three or more Heteroatoms, and their Fused Carbocyclic Derivatives
    Jason Smith
    7. Six-membered Rings with One Heteroatom, and their Fused Carbocyclic Derivatives
    Nuno Maulide
    8. Six-membered Rings with Two Heteroatoms, and their Fused Carbocyclic Derivatives
    Steven Weinreb
    9. Six-membered Rings with Three or more Heteroatoms, and their Fused Carbocyclic Derivatives
    Santosh Gharpure
    10. Ring Systems with at least Two Fused Heterocyclic Five- or Six-membered Rings with no Bridgehead Heteroatom
    Fawaz Aldabbagh
    11. Bicyclic 5-5 and 5-6 Fused Ring Systems with at least One Bridgehead (Ring Junction)
    Geraldine Masson
    12. Five- and Six-membered Fused Systems with Bridgehead (Ring Junction) Heteroatoms Including 6-6 Bicyclic with One or Two N or Other Heteroatoms, Polycyclic, Spirocyclic
    Lucjan Strekowski
    13. Seven-membered Heterocyclic Rings and their Fused Derivatives
    Floris Rutjes
    14. Eight-membered and larger Heterocyclic Rings and their Fused Derivatives; Other Seven-membered Rings
    Ari Koskinen

Product details

  • No. of pages: 11592
  • Language: English
  • Copyright: © Elsevier Science 2021
  • Published: November 23, 2021
  • Imprint: Elsevier Science
  • Hardcover ISBN: 9780128186558
  • eBook ISBN: 9780128186565

About the Editors in Chief

David Black

Professor David Black, School of Chemistry, University of New South Wales, Australia. Professor David Black studied chemistry at the University of Sydney. Following a Masters degree mentored by Francis Lions, he was awarded an Overseas Scholarship of the Royal Commission for the Exhibition of 1851 to undertake a PhD in Cambridge with Lord Todd. After post-doctoral research with Thomas Katz at Columbia University, he was appointed to a lectureship at Monash University. In 1983 he moved to the chair of organic chemistry at the University of New South Wales. He has spent periods of study leave at the ETH Zürich (with Albert Eschenmoser), Würzburg University as an Alexander von Humboldt Fellow (with Siegfried Hünig) and Cambridge University (with Alan Battersby). He has also held Visiting Professorships in Tokyo, Auckland, Göttingen, Innsbruck and Kobe. He has won the Rennie, Smith, Birch and Leighton Medals of the Royal Australian Chemical Institute, of which he served as National President in 1998. David Black has also contributed to international science as Secretary General of the International Union of Pure and Applied Chemistry from 2004-2011, and Secretary General of the International Council for Science from 2011-2018. He is a Fellow of the Australian Academy of Science and an Officer of the Order of Australia. He was recently awarded the 2017 Craig Medal of the Australian Academy of Science. Professor Black has made major contributions to organic chemistry in the general fields of heterocyclic chemistry, coordination chemistry and natural products. His research has focused on the design and synthesis of new molecular structural types, often related to important known natural products, but displaying deliberate reactivity variations that are not found in nature. He was a pioneer in the use of metal coordination for the control of organic reactions, and has also discovered new reactions of activated indoles leading to the construction of molecular receptors and small peptide mimics.

Affiliations and Expertise

School of Chemistry, University of New South Wales, Australia

Janine Cossy

Professor Janine Cossy, Laboratoire de Chimie Organique, ESPCI, Paris, France. Professor Janine Cossy graduated from the University of Reims working under the supervision of Prof. Jean-Pierre Pète. After a postdoctoral stay with Prof. Barry Trost (1980-1982) at the University of Wisconsin, she returned to Reims where she became Director of Research of the CNRS in 1990. The same year, she moved to Paris to become Professor of Organic Chemistry at the Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI ParisTech). She has published over 450 articles and filed thirteen patents in the field of synthetic organic chemistry and natural product synthesis. She is Associate Editor at Organic Letters since 2005. Awards: CNRS Bronze Medal (1987), CNRS Silver Medal (1996), Royal Society Rosalind Franklin International Lectureship (2005), Prix Le Bel from the Société Chimique de France (2009), Usha Ranjan Ghatak Endowment Award (2015), E.C. Taylor Senior Award of the International Society of Heterocyclic Chemistry (2015), Susan P. and Barry M. Trost Award in Organic Synthesis (2016), Tarrant Distinguished Visiting Professorship of Organic Chemistry (2016). Member of the Advisory Board: Journal of Organic Chemistry (2001-2004); New Journal of Chemistry (2001-2004); Current Topics in Medicinal Chemistry (2006-2009); European Journal of Organic Chemistry (2000-2010); Tetrahedron and Tetrahedron Letters (since 2003); Letter of Organic Chemistry (since 2006); Trends in Organic Chemistry (since 2006); The open Organic Chemistry Journal (since 2007); Synthesis, Synlett and Synfact (since 2009); Arkivoc (since 2009); Heterocycles (since 2009); Mediterranean Journal of Chemistry (MedJChem) (since 2011); ISRN Organic Chemistry (since 2010); Topics in Heterocyclic Chemistry (since 2011); Reports in Organic Chemistry (since 2011).

Affiliations and Expertise

Laboratoire de Chimie Organique, ESPCI, Paris, France

Christian Stevens

Prof. Dr. Christian Stevens, Faculty of Bioscience Engineering, University of Ghent, Belgium. Prof. Dr. Ir. Christian V. Stevens is professor at the Department of Sustainable Organic Chemistry and Technology at the Faculty of Bioscience Engineering (Ghent University). He graduated at the same department as bio-engineer in chemistry in 1988 and obtainded a PhD in 1992 as fellow of the National Fund for Scientific Research. During his PhD he also worked as a research assistant of the University of Southern California (USC), Los Angeles, USA with Prof. C.E. McKenna. After his PhD at Ghent University under the direction of Prof. N. De Kimpe, he did post-doctoral work at the Center for Heterocyclic Compounds at the University of Florida, USA under the direction of Prof. A. R. Katritzky as a NATO Research Fellow. He became group leader in the group of Prof. Katritzky in 1993. He returned as a postdoctoral fellow of the National Fund for Scientific Research. In 1994, he also made a short postdoctoral stay at the University of Alicante (Spain) under the direction of Prof. M. Yus. In 1995, he became group leader of the National Fund for Scientific Research and became guest professor in 1997 at Ghent University. In 2000, he became professor at the current Faculty of Bioscience Engineering and developed the research group SynBioC of which he is the director. He became full professor in 2014. Member of the Editorial Board: Green Chemistry; Advances in Heterocyclic Chemistry; Arkivoc; Biofuels, Bioproducts and Biorefining (Biofpr, Wiley); Current Opinion in Green and Sustainable Chemistry. Member of the International Advisory Board: European Journal of Organic Chemistry; Journal of Flow Chemistry. Series Editor: Wiley series on Renewable Resources.

Affiliations and Expertise

Faculty of Bioscience Engineering, University of Ghent, Belgium

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