This comprehensive handbook is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level. Over 100 chapters provide abundant information of a wide range of topics that extend from the evolutionary aspects of alcohol consumption and the prevalence of alcohol misuse to programmed cell death. Each chapter is highly illustrated with tables and figures making this a valuable reference for students, clinicians and researchers alike.

Key Features

*Over 100 chapters conveniently divided into 3 sections *Represents a 'one-stop-shop' of information with suitable indexing of the various pathways and processes *Each chapter is highly illustrated with tables as well as figures


Researchers involved in the field of alcohol-related harm, institutions, libraries, PhD students, clinicians and pathologists.

Table of Contents

Contributors xiii Preface xxix Foreword xxxi Volume 1 Part I: General Aspects of Alcohol Toxicity, Consumption, and Disease 1 1. Evolutionary and Historical Aspects of Ethanol Ingestion 3 Robert Dudley 2. Alcohol Metabolism: General Aspects 15 Charles S. Lieber 3 Intake of Different Alcoholic Beverages and Life-style and Psychosocial Factors 27 John Barefoot and Morten Grønbæk 4. Genetic Aspects of Alcohol Metabolism: An Overview 31 Stephen J. Marshall and Geoff K. Chambers 5. Predictors of Alcohol Consumption 49 Kari Poikolainen 6. Binge Drinking: Patterns, Explanations, and Policy 59 Holly E. Ventura, Chris L. Gibson, J. Mitchell Miller and Alex R. Piquero 7. Breath and Blood Alcohol 75 Marion Pavlic and Petra Grubwieser 8. Effects of Food and Body Composition on Blood Alcohol Levels 87 Harold Kalant 9. Disposal of Ethanol Carbon Atoms 103 M-A. Cornier 10. Effect of Alcohol on Water and Sodium Homeostasis 111 Ramón Rodrigo and Gonzalo Rivera 11. Energy from Alcohol 121 Michael J. Haas 12. The Mediterranean Diet and the Contribution and Role of Alcohol 135 Maria Isabel Covas 13. The Role of Alcohol in Injury Deaths 147 Philippe Lunetta and Gordon S. Smith 14. Death from Alcohol Poisoning 165 James A. Crampton and Kathleen Berry 15. Alcohol and the Workplace 175 Valentino Patussi and Laura Mezzani 16. Alcohol Misuse in Adolescents: Epidemiology, Clinical Characteristics, Diagnosis, and Treatment 181 Dawn L. Thatcher and Duncan B. Clark 17. Alcohol Misuse in Adolescents: Individual


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Academic Press
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About the editors

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a senior member of King's College London. He is also Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well being. He is a member of the Editorial Board of Drug and Alcohol Dependence and a founding member of the Editorial Board of Addiction Biology. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is Editor of the influential works The Handbook Of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse and The Handbook of Cannabis and Related Pathologies (all published by Academic Press-Elsevier). Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctoral degree (DSc). Professor Preedy was elected as a Fellow of the Institute of Biology in 1995 and also as a Fellow to the Royal College of Pathologists in 2000. He was then elected as a Fellow of the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health and Hygiene (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Department of Dietetics, King's College London, UK

Ronald Ross Watson

Ronald R. Watson, Ph.D., attended the University of Idaho but graduated from Brigham Young University in Provo, Utah, with a degree in chemistry in 1966. He earned his Ph.D. in biochemistry from Michigan State University in 1971. His postdoctoral schooling in nutrition and microbiology was completed at the Harvard School of Public Health, where he gained 2 years of postdoctoral research experience in immunology and nutrition. From 1973 to 1974 Dr. Watson was assistant professor of immunology and performed research at the University of Mississippi Medical Center in Jackson. He was assistant professor of microbiology and immunology at the Indiana University Medical School from 1974 to 1978 and associate professor at Purdue University in the Department of Food and Nutrition from 1978 to 1982. In 1982 Dr. Watson joined the faculty at the University of Arizona Health Sciences Center in the Department of Family and Community Medicine of the School of Medicine. He is currently professor of health promotion sciences in the Mel and Enid Zuckerman Arizona College of Public Health. Dr. Watson is a member of several national and international nutrition, immunology, cancer, and alcoholism research societies. Among his patents he has one on a dietary supplement; passion fruit peel extract with more pending. He continues to do research in animals and in clinical trials on dietary supplements and health including studies using omega-3 fatty acids in heart disease prevention and therapy. For 30 years he was funded by Wallace Research Foundation to study dietary supplements in health promotion. Dr. Watson has edited more than 110 books on nutrition, dietary supplements and over-the-counter agents, and drugs of abuse as scientific reference books. He has published more than 500 research and review articles.

Affiliations and Expertise

Mel and Enid Zuckerman College of Public Health, and School of Medicine, University of Arizona, Tucson, AZ, USA


" excellent addition to a reference library and to the field of addictionology. ...a great reference -- all you want to know in 2005 regarding alcohol and its medical consequences. ...I highly recommed it for researchers in the field and medical libraries." - DOODY'S (2005)