Comprehensive Handbook of Alcohol Related Pathology

Comprehensive Handbook of Alcohol Related Pathology

1st Edition - December 24, 2004

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  • Editors: Victor Preedy, Ronald Watson
  • eBook ISBN: 9780080502311
  • Hardcover ISBN: 9780125643702

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This comprehensive handbook is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level. Over 100 chapters provide abundant information of a wide range of topics that extend from the evolutionary aspects of alcohol consumption and the prevalence of alcohol misuse to programmed cell death. Each chapter is highly illustrated with tables and figures making this a valuable reference for students, clinicians and researchers alike.

Key Features

*Over 100 chapters conveniently divided into 3 sections
*Represents a 'one-stop-shop' of information with suitable indexing of the various pathways and processes
*Each chapter is highly illustrated with tables as well as figures


Researchers involved in the field of alcohol-related harm, institutions, libraries, PhD students, clinicians and pathologists.

Table of Contents

  • Contributors xiii
    Preface xxix
    Foreword xxxi
    Volume 1
    Part I: General Aspects of Alcohol Toxicity, Consumption, and Disease 1
    1. Evolutionary and Historical Aspects of Ethanol Ingestion 3
    Robert Dudley
    2. Alcohol Metabolism: General Aspects 15
    Charles S. Lieber
    3 Intake of Different Alcoholic Beverages and Life-style and Psychosocial Factors 27
    John Barefoot and Morten Grønbæk
    4. Genetic Aspects of Alcohol Metabolism: An Overview 31
    Stephen J. Marshall and Geoff K. Chambers
    5. Predictors of Alcohol Consumption 49
    Kari Poikolainen
    6. Binge Drinking: Patterns, Explanations, and Policy 59
    Holly E. Ventura, Chris L. Gibson, J. Mitchell Miller and Alex R. Piquero
    7. Breath and Blood Alcohol 75
    Marion Pavlic and Petra Grubwieser
    8. Effects of Food and Body Composition on Blood Alcohol Levels 87
    Harold Kalant
    9. Disposal of Ethanol Carbon Atoms 103
    M-A. Cornier
    10. Effect of Alcohol on Water and Sodium Homeostasis 111
    Ramón Rodrigo and Gonzalo Rivera
    11. Energy from Alcohol 121
    Michael J. Haas
    12. The Mediterranean Diet and the Contribution and Role of Alcohol 135
    Maria Isabel Covas
    13. The Role of Alcohol in Injury Deaths 147
    Philippe Lunetta and Gordon S. Smith
    14. Death from Alcohol Poisoning 165
    James A. Crampton and Kathleen Berry
    15. Alcohol and the Workplace 175
    Valentino Patussi and Laura Mezzani
    16. Alcohol Misuse in Adolescents: Epidemiology, Clinical Characteristics,
    Diagnosis, and Treatment 181
    Dawn L. Thatcher and Duncan B. Clark
    17. Alcohol Misuse in Adolescents: Individual Differences, Prevention,
    Identification, and Intervention 195
    Rebecca Lebeau-Craven, Holly A. Sindelar, James Murphy and Nancy P. Barnett
    PreedyVol1_FM.qxd 19/11/04 9:03 PM Page v
    18. What is the Impact of Alcohol on Learning in University Students? 215
    Bert Aertgeerts
    19. The Relationship Between Alcohol Misuse and the Homelessness 221
    Colleen Clark and Alexander R. Rich
    20. Alcohol and Sport Activities: Spectator’s Perspective 241
    Eli Torild Hellandsjo Bu
    Part II: Damage/Disease
    (i) General Aspects of Pathology 251
    21. An Overview of Pathologies Occurring in Alcohol Abusers 253
    Valentino Patussi, Laura Mezzani and Emanuele Scafato
    22. Gender Differences in Alcohol Pathology 261
    Joaquim Fernández-Solà, Josep-María Nicolás, Romon Estruch and
    Alvaro Urbano-Márquez
    23. Psychological Effects of Alcohol Misuse 279
    Marc Walter, Gerhard Dammann and Burghard F. Klapp
    24. The Effect of Alcohol on Quality of Life 295
    Paul J. Allison
    25. Alcohol and Road Accidents 309
    Andrea Fabbri, Giulio Marchesini and Alberto Vandelli
    26. Trauma and Alcohol 321
    Richard D. Blondell
    27. Clinical Implications of Alcohol Misuse for Surgery 337
    S. Shourie, P.S. Haber, R. Boughton, and K.M. Conigrave
    28. Fetal Alcohol Spectrum Disorder 349
    Christina D. Chambers
    29. Nutritional Status in Alcoholics 361
    Romon Estruch, Emilio Sacanella, Joaquim Fernández-Solà and Josep-Maria Nicolás
    30. Alcohol and Body Composition 377
    Giovanni Addolorato, Carlo Ancona, Esmeralda Capristo, Giovanni Gasbarrini and the
    Alcohol Related Diseases Study Group
    31. Beneficial Components of White Wine 387
    A.A.E. Bertelli
    32. Polyphenols and Alcohol: Complementary Mechanisms for the Protective
    Effects of Moderate Wine Consumption 393
    A. Di Castelnuovo, S. Rotondo and G. de Gaetano
    33. Overview of ALDH Polymorphism: Relation to Cardiovascular Effects of Alcohol 409
    Shih-Jiun Yin and Giia Sheun Peng
    34. Overview on the Effects of Amount and Type of Alcohol on Morbidity and Mortality 425
    Morten Grønbæk and Lina Steinrud Mørch
    35. Alcohol-related Mortality in Russia 441
    A.V. Nemtsov and P.P. Ogurtsov
    (ii) Organ Damage 465
    36. Epidemiology and Risk Factors Involved in Alcoholic Liver Disease 467
    Ulrik Becker
    37. Polymorphism and Alcoholic Liver Disease 481
    José María Ladero
    38. Liver Injury During Alcohol Use and Withdrawal 491
    Abraham P. Bautista
    39. Alcohol Consumption and Diabetes Mellitus 501
    Angelo Avogaro and Antonio Tiengo
    40. Alcoholic Ketoacidosis 511
    Hitender Jain and M. Duggal
    41. Alcohol, Alcoholism and Effects on the Kidney and Kidney Disease 519
    Judith H. Veis
    42. Alcohol Intake and the Lower Urinary Tract 527
    C.P. Arun
    43. Alcohol and Prostate Cancer 531
    Katrine Albertsen and Morten Grønbæk
    44. Oral Health and Alcohol 551
    Jukka H. Meurman and Riitta Suuronen
    Volume 2
    45. Alcohol and the Gastrointestinal Tract 557
    Gerlinde Egerer, Felix Stickel and Helmut K. Seitz
    46. Alcohol, ALDH2 Genotypes and Intestinal Cancer 571
    Motoi Murata
    47. Alcohol and Pancreatitis 577
    Alexander Schneider, Stephan L. Haas and Manfred V. Singer
    48. The Skin and Alcohol 599
    Elisabeth Higgins
    49. Alcohol, Blood Pressure and Hypertension 607
    Ian B. Puddey, Renate R. Zilkens and Lawrence J. Beilin
    50. Alcohol and Stroke 627
    Douglas A. Dulli and Madeleine C. Geraghty
    51. Alcoholic Cardiomyopathy 647
    Michael Sander, Christian von Heymann, Jan Braun,
    Adrian Borges and Claudia Spies
    52. Epidemiologic Aspects of ALDH2 Genotypes and Cardiovascular Parameters 659
    Tomonori Okamura
    53. Alcoholic Myopathy: Clinical Aspects 671
    Joaquim Fernández-Solà, Josep-María Nicolás
    Romon Estruch, Emilio Sacanella, Joseph-María Grau and
    Alvaro Urbano-Márquez
    54. Alcohol and the Eye: Friend or Foe 693
    John R. Trevithick and Kenneth P. Mitton
    55. Marchiafava–Bignami Disease in Alcoholism 713
    Yahya Çelik
    56. Peripheral Neuropathy 719
    Angelo Ammendola and Francesco Bravaccio
    (iii) Cells, Pathways, Interactions, Processes 733
    57. Defects in Methionine Metabolism: Its Role in Ethanol-induced Liver Injury 735
    Kusum K. Kharbanda and Anthony J. Barak
    58. Roles of Kupffer Cells in Alcoholic Liver Disease 749
    Yoshiyuki Takei, Nobuyuki Enomoto, Kenichi Ikejima, Shunhei Yamashina,
    Tsuneo Kitamura and Nobuhiro Sato
    59. The Role of the Stellate Cell in Alcohol Mediated Tissue Injury 757
    R.G. Batey and Jianhua Wang
    60. The Role of T Lymphocytes in the Pathogenesis of Alcoholic Liver Disease 763
    Q. Cao and R.G. Batey
    61. Oxidative Stress in Alcoholic Liver Disease: Clinical Studies 775
    Carmela Loguercio and Alessandro Federico
    62. The Relationship between Alcohol-induced Apoptosis and Oxidative Stress in the Liver 785
    Juan Sastre, Juan Bautista Miñana, Federico V. Pallardó and José Viña
    63. Alcohol and HIV Interactions in the Natural History and Treatment of HIV/AIDS 799
    Thomas F. Kresina and Laura W. Cheever
    64. Alcohol and Hepatitis Virus Interactions in Liver Pathology 819
    Bin Gao
    65. Moderate Alcohol and Fibrosis in Chronic Viral Hepatitis 833
    Johan Westin
    66. Ethanol–Taurine Interactions in the Brain: Mechanisms and
    Pathophysiological Implications 845
    Jan Albrecht, Magealena Zielinska, Jeffrey W. Allen,
    Offie P. Soldin and Michael Aschner
    67. The Effect of Ethanol on Ion Channels in the Brain: A New Look 855
    Hugh E. Criswell and George R. Breese
    68. A Nitric Oxide Signaling Pathway Protects the Developing Brain against
    Alcohol-induced Neuronal Death 871
    Ana M. Hutton Kahrberg, Nicholas J. Pantazis, Ross A. McKim and Daniel J. Bonthius
    69. Signaling Pathways in the Heart and Moderate Alcohol Intake 887
    Mary O. Gray
    70. Effects of Alcohol on Vascular Function 901
    Jocelyn L. Cook and Sandra T. Davidge
    71. Vascular and Biochemical Effects of Moderate Alcohol Consumption:
    Mechanisms of Protection Against Cardiovascular Disease 911
    Asf je Sierksma, Diederick E. Grobbee and Henk F.J. Hendriks
    72. Alcohol and Xenobiotics in Placenta Damage 921
    Cleofina Bosco
    73. Molecular Mechanisms in Fetal Alcohol Syndrome: Shh-signaling 937
    Sara C. Ahlgren
    74. The Process of Bacterial Translocation and Implications for Health in Alcoholics 949
    Valeria Bender Braulio
    75. Alcohol, Altered Gut Permeability, and Endotoxins 965
    Alexandr Parlesak
    76. Hormonal Responses in Alcoholism 979
    Bernard Campillo
    77. Alcohol-induced Changes in the GH–IGF Axis 991
    Charles H. Lang and Robert A. Frost
    78. Mechanisms in Prostate Damage by Alcohol 1007
    Jose A. Castro and Gerardo D. Castro
    79. Signaling Pathways in Human Breast Cells in Response to Alcohol:
    Mechanisms for Alcohol-induced Breast Cancer 1017
    Ernest B. Izevbigie
    80. The Ubiquitin–Proteasome System in Alcohol-Induced Pathology 1027
    Terrence M. Donohue, Jr. and Samuel W. French
    81. Alcohol and Alkylating Agents 1041
    David B. Couch
    82. DNA Damage Resulting from Alcohol Abuse with Special Reference
    to the Brain 1049
    Philip J. Brooks, Jacob A. Theruvathu and Raghu G. Nath
    83. Purine Metabolism and the Influence of Alcoholic Beverages 1069
    Y. Suwa
    84. The Role of PKC Isozymes in Mediating Responses to Ethanol 1083
    John S. Ellingson
    85. Ethanol Modulation of cAMP-dependent Protein Kinase Subunits Activity:
    Mechanisms and Functional Consequences 1099
    Anastasia Constantinescu
    86. Adhesion Molecules and Alcohol Consumption 1113
    Emilio Sacanella, Romon Estruch, Josep-Maria Nicolás, and Joaquim Fernández-Solá
    87. Glucose-regulated Stress Proteins (GRPs) and Alcohol 1127
    Eckhard Mühlbauer and H. Rommelspacher
    88. Heat Shock Proteins and Alcohol 1141
    Luisa Schiaffonati
    89. Role of Oxidative Stress in Alcohol-Induced Mitochondrial Dysfunction 1153
    Shannon M. Bailey
    90. Alcohol and Apoptosis 1175
    Benita L. McVicker, Dean J. Tuma, Amin A. Nanji and Carol A. Casey
    Volume 3
    91. Alcohol and Fatty Acid Ethyl Esters 1195
    Raneem O. Salem and Michael Laposata
    92. Modification of Proteins by Reactive Ethanol Metabolites:
    Adduct Structure, Functional and Pathological Consequences 1209
    Simon Worrall and Geoffrey M. Thiele
    93. The Effect of Acetaldehyde on Plasma 1223
    Arthur S. Brecher
    94. Autoantibodies in Alcohol-related Tissue Diseases 1245
    Emanuele Albano and Matteo Vidali
    95. Alcohol-induced Membrane Damage 1253
    Junko Adachi, Hideyuki Nushida, Yasuhiro Ueno and Victor R. Preedy
    96. Alcohol Abuse and Eating Disorders 1263
    Marlene B. Schwartz and Rajita Sinha
    97. The Relationship Between Obesity and Alcoholic Pathology 1277
    Daniel Bunout, María Pía De la Maza and Sandra Hirsch
    98. Protein Deficiency and Alcohol: Interactions and Organ Effects 1289
    Emilio González-Reimers and Francisco Santolaria-Fernández
    99. Tryptophan Metabolism and Alcoholism 1303
    Abdulla A.-B. Badawy
    Part III: Selective Methods Used in Alcohol Research 1325
    100. Selective Methods Used in Alcohol Research: Screening in Primary Care – Methods
    and Approaches 1327
    Adam J. Gordon, Joseph Conigliaro and David A. Fiellin
    101. Psychometric Assessment of Alcohol Use 1347
    Andrew J. Levine, Steven A. Castellon and Charles H. Hinkin
    102. Self-reported Intake of Alcohol: Methods and Approaches 1367
    Ulrik Kesmodel
    103. Use of the DSM-IV: Methods and Approaches 1383
    Deborah Hasin and Rachel Y. Waxman
    104. The Alcohol-related Problems Survey: Developing and
    Testing a Screening Measure for Older Adults 1403
    Arlene Fink
    105. The Rapid Alcohol Problems Screen: Methods and Application 1415
    Cheryl J. Cherpitel
    106. Methods for Determining Blood Alcohol Concentration: Current and
    Retrospective 1429
    Kate B. Carey and John T.P. Hustad
    107. Urinary Markers of Alcohol Consumption 1445
    Anja Kroke and Jutta Dierkes
    108. Methods for Measuring Genetic Variations in ADH
    and SLDH Loci: A Practical Approach 1459
    Stephen J. Marshall, Geoff K. Chambers and Darren Day
    109. Histological Localization of Alcohol Dehydrogenase: Methods,
    Approaches and Applications 1475
    Susana E. Martínez, Sergio Porté, Julia Vaglenova, Xavier Parés and Jaume Farrés
    110. Assays for Alcohol and Aldehyde Dehydrogenase: Methods,
    Approaches and Applications 1489
    Stewart Campbell and Peter M. Timms
    111. Detecting ADH and ALDH Enzymes in Cells and Tissues using Western Blotting 1501
    Connie Cheung and Camilla K. Smith Pease
    112. Use of Selectively Bred Alcohol-preferring Rats to Study Alcohol
    Abuse, Relapse and Craving 1515
    R.L. Bell, Z.A. Rodd, J.M. Murphy and W.J. McBride
    113. Animal Models of Chronic Alcohol-Induced Liver Damage 1535
    Jason C. Lambert and Gavin E. Arteel
    114. Acute Ethanol Dosing Regimens: Methods and Approaches 1551
    Ernest L. Abel
    115. Use of Isolated Cells in the Study of Ethanol-Induced Hepatotoxicity 1559
    Dahn L. Clemens
    116. Animal Models of Fetal Alcohol Syndrome: Methods and Approaches 1573
    George K. Acquaah-Mensah
    117. Genetically Engineered Animals in Alcohol Research 1583
    David F. Werner, Dev Chandra and Gregg E. Homanics
    118. cDNA Arrays in Alcohol-Related Pathology: Methods and Approaches 1597
    R.S. Gooch, T.J. Worst, W.M. Freeman and K.E. Vrana
    119. Practical Methods for Determining mRNA Levels in Alcohol-Exposed
    Tissues and Its Application to Experimental Pathology 1611
    Tatsuo Nakahara, Ross J. Hunter, Victor R. Preedy, Colin R. Martin, and
    Matthew E. Reilly
    120. Diagnosis of Fetal Alcohol Syndrome: Measurement of the
    Facial Dysmorphology 1619
    Ernesta M. Meintjes and Tania S. Douglas
    121. Nuclear Magnetic Resonance: Methods and Application to
    Alcohol Effects in the Liver 1635
    Marie-Christine-Beauvieux and Jean-Louis Gallis
    Index 1651

Product details

  • No. of pages: 2192
  • Language: English
  • Copyright: © Academic Press 2004
  • Published: December 24, 2004
  • Imprint: Academic Press
  • eBook ISBN: 9780080502311
  • Hardcover ISBN: 9780125643702

About the Editors

Victor Preedy

Professor Preedy has been elected as a Fellow to the following Royal Societies: The Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health and Hygiene, the Royal Society for Public Health, the Royal Society of Chemistry, and the Royal Society of Medicine. He was founding Director of the Genomics Centre at King’s College London and held the post from 2006 to 2020. He is a leading expert on the science of health and has a long-standing interest in disease processes, biomarkers, and tissue pathology. He has lectured nationally and internationally. Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Professor in the Department of Clinical Biochemistry at King’s College Hospital, London, UK Emeritus Professor in Faculty of Life Sciences and Medicine at King’s College London, UK Visiting Professor at the University of Hull, UK

Ronald Watson

Ronald Watson
Ronald Ross Watson, PhD, is Professor of Health Promotion Sciences at the University of Arizona, Mel and Enid Zuckerman College of Public Health. Dr. Watson began his research in public health at the Harvard School of Public Health as a Fellow in 1971 doing field work on vaccines in Saudi Arabia. He has done clinical studies in Colombia, Iran, Egypt, Saudi Arabia and the United States which provides a broad international view of public health. He has served in the military reserve hospital for 17 years with extensive training in medical responses to disasters as the chief biochemistry officer of a general hospital, retiring as a Lt. Colonel. He is a distinguished member of several national and international nutrition, immunology, and cancer societies. Dr. Watson’s career has involved studying many lifestyle aspects for their uses in health promotion. He has edited over 100 biomedical reference books and 450 papers and chapters. His teaching and research focuses on alcohol, tobacco, and drugs of abuse in heart function and disease in mouse models.

Affiliations and Expertise

Professor, Mel and Enid Zuckerman College of Public Health and School of Medicine, Arizona Health Sciences Center, University of Arizona, Tucson, AZ, USA

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