Comprehensive Clinical Nephrology

Comprehensive Clinical Nephrology

6th Edition - June 26, 2018

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  • Authors: Richard Johnson, John Feehally, Jurgen Floege, Marcello Tonelli
  • eBook ISBN: 9780323547192
  • Hardcover ISBN: 9780323479097

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Written and edited by world leaders in nephrology, Comprehensive Clinical Nephrology, 6th Edition, by Drs. John Feehally, Jurgen Floege, Richard J. Johnson, and Marcello Tonelli, provides current information on clinical procedures and conditions as well as the scientific facts and pathophysiology that are foundational to nephrology practice. Ideal for practicing nephrologists, fellows, residents, and internists, it thoroughly covers fluids and electrolytes, hypertension, diabetes, dialysis, and transplantation, and more – all in a single convenient volume.

Key Features

  • Popular, color-coded algorithms provide easy access to key content: yellow boxes for general information, green boxes for therapeutic intervention, and blue boxes for necessary investigations.
  • A "just right" amount of basic science and practical clinical guidance helps you make efficient and informed decisions.
  • More than 1,500 full-color illustrations highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management.

Table of Contents

  • SECTION I Essential Renal Anatomy and Physiology

    1 Renal Anatomy, 1

    2 Renal Physiology, 14

    SECTION II Investigation of Renal Disease

    3 Assessment of Glomerular Filtration Rate, 29

    4 Urinalysis, 39

    5 Imaging, 53

    6 Renal Biopsy, 72

    SECTION III Fluid and Electrolyte Disorders

    7 Disorders of Extracellular Volume, 80

    8 Disorders of Water Metabolism, 94

    9 Disorders of Potassium Metabolism, 111

    10 Disorders of Calcium, Phosphate, and Magnesium Metabolism, 124

    11 Normal Acid-Base Balance, 142

    12 Metabolic Acidosis, 149

    13 Metabolic Alkalosis, 160

    14 Respiratory Acidosis, Respiratory Alkalosis, and Mixed Disorders, 170

    SECTION IV Glomerular Disease

    15 Introduction to Glomerular Disease: Clinical Presentations, 184

    16 Introduction to Glomerular Disease: Histologic Classification and Pathogenesis, 199

    17 Minimal Change Disease, 209

    18 Primary and Secondary (Non-Genetic) Causes of Focal and Segmental Glomerulosclerosis, 219

    19 Inherited Causes of Nephrotic Syndrome, 232

    20 Membranous Nephropathy, 240

    21 Membranoproliferative Glomerulonephritis and Cryoglobulinemic Glomerulonephritis, 254

    22 Glomerulonephritis Associated With Complement Disorders, 263

    23 Immunoglobulin A Nephropathy and IgA Vasculitis (Henoch-Schönlein Purpura), 270

    24 Anti–Glomerular Basement Membrane Disease and Goodpasture Disease, 281

    25 Renal and Systemic Vasculitis, 290

    26 Lupus Nephritis, 306

    27 Renal Amyloidosis and Glomerular Diseases With Monoclonal Immunoglobulin Deposition, 320

    28 Rare Glomerular Disorders, 333

    29 Thrombotic Microangiopathies, Including Hemolytic Uremic Syndrome, 343

    SECTION V Diabetic Kidney Disease

    30 Pathogenesis, Clinical Manifestations, and Natural History of Diabetic Kidney Disease, 357

    31 Prevention and Treatment of Diabetic Kidney Disease, 376

    32 Management of the Diabetic Patient With Chronic Kidney Disease, 385

    SECTION VI Hypertension

    33 Normal Blood Pressure Control and the Evaluation of Hypertension, 396

    34 Primary Hypertension, 412

    35 Nonpharmacologic Prevention and Treatment of Hypertension, 422

    36 Pharmacologic Treatment of Hypertension, 430

    37 Evaluation and Treatment of Hypertensive Emergencies and Urgencies, 444

    38 Endocrine Causes of Hypertension: Aldosterone, 453

    39 Other Endocrine Causes of Hypertension, 463

    40 Neurogenic Hypertension, Including Hypertension Associated With Stroke or Spinal Cord Injury, 473

    SECTION VII Renovascular Disease

    41 Renovascular Hypertension and Ischemic

    Nephropathy, 482

    SECTION VIII Pregnancy and Renal Disease

    42 Renal Physiology and Complications in Normal Pregnancy, 502

    43 Pregnancy With Preexisting Kidney Disease, 522

    SECTION IX Hereditary and Congenital Diseases of the Kidney

    44 Autosomal Dominant Polycystic Kidney Disease, 532

    45 Other Cystic Kidney Diseases, 545

    46 Alport Syndrome and Other Familial Glomerular Syndromes, 560

    47 Inherited Disorders of Sodium and Water Handling, 575

    48 Fanconi Syndrome and Other Proximal Tubule Disorders, 586

    49 Sickle Cell Diseases and the Kidney, 597

    50 Congenital Anomalies of the Kidney and Urinary Tract, 607

    SECTION X Infectious Diseases and the Kidney

    51 Urinary Tract Infections in Adults, 626

    52 Tuberculosis of the Urinary Tract, 639

    53 Fungal Infections of the Urinary Tract, 650

    54 The Kidney in Schistosomiasis, 655

    55 Glomerular Diseases Associated With Infection, 664

    56 Human Immunodeficiency Virus Infection and the Kidney, 679

    SECTION XI Urologic Disorders

    57 Nephrolithiasis and Nephrocalcinosis, 689

    58 Urinary Tract Obstruction, 704

    59 Urologic Issues for the Nephrologist, 717

    SECTION XII Tubulointerstitial and Vascular Diseases

    60 Acute Interstitial Nephritis, 729

    61 Primary Vesicoureteral Reflux and Reflux Nephropathy, 738

    62 Chronic Interstitial Nephritis, 748

    63 Endemic Nephropathies, 761

    64 Myeloma and the Kidney, 767

    SECTION XIII Renal Disease and Cancer

    65 Onconephrology: Kidney Disease in Cancer Patients, 776

    SECTION XIV Acute Kidney Injury

    66 Pathophysiology and Etiology of Acute Kidney Injury, 786

    67 Acute Kidney Injury in the Tropics, 802

    68 Diagnosis and Clinical Evaluation of Acute Kidney Injury, 810

    69 Epidemiology and Prognostic Impact of Acute Kidney Injury, 820

    70 Prevention and Nondialytic Management of Acute Kidney Injury, 825

    71 Dialytic Management of Acute Kidney Injury and Intensive Care Unit Nephrology, 838

    72 Dialytic Management of Refractory Heart Failure, 852

    73 Hepatorenal Syndrome, 859

    SECTION XV Drug Therapy in Kidney Disease

    74 Principles of Drug Therapy, Dosing, and Prescribing in Chronic Kidney Disease and Renal Replacement Therapy, 870

    75 Common Issues in Prescribing in Kidney Disease and Renal Replacement Therapy, 880

    76 Herbal and Over-the-Counter Medicines and the Kidney, 894

    SECTION XVI Chronic Kidney Disease and the Uremic Syndrome

    77 Epidemiology of Chronic Kidney Disease and Dialysis, 903

    78 Pathophysiology of Disease Progression in Proteinuric and Nonproteinuric Kidney Disease, 913

    79 Retarding Progression of Kidney Disease, 924

    80 Clinical Evaluation and Management of Chronic Kidney Disease, 935

    81 Cardiovascular Disease in Chronic Kidney Disease, 942

    82 Anemia in Chronic Kidney Disease, 958

    83 Other Blood and Immune Disorders in Chronic Kidney Disease, 967

    84 Bone and Mineral Disorders in Chronic Kidney Disease, 979

    85 Neurologic Complications of Chronic Kidney Disease, 996

    86 Gastroenterology and Nutrition in Chronic Kidney Disease, 1002

    87 Dermatologic Manifestations of Chronic Kidney Disease, 1013

    88 Acquired Cystic Kidney Disease and Malignant Neoplasms, 1022

    SECTION XVII Geriatric and Palliative Nephrology

    89 Geriatric Nephrology, 1028

    SECTION XVIII Dialytic Therapies

    90 Approach to Renal Replacement Therapy, 1036

    91 Vascular Access for Dialytic Therapies, 1050

    92 Diagnostic and Interventional Nephrology, 1062

    93 Hemodialysis: Principles and Techniques, 1073

    94 Hemodialysis: Dialysis Prescription and Adequacy, 1082

    95 Acute Complications During Hemodialysis, 1090

    96 Peritoneal Dialysis: Principles, Techniques, and Adequacy, 1103

    97 Complications of Peritoneal Dialysis, 1114

    98 Extracorporeal Therapies for Drug Overdose and Poisoning, 1124

    99 Plasma Exchange, 1132

    SECTION XIX Transplantation

    100 Immunologic Principles in Kidney Transplantation, 1141

    101 Immunosuppressive Medications in Kidney Transplantation, 1154

    102 Evaluation and Preoperative Management of Kidney Transplant Recipient and Donor, 1163

    103 Kidney Transplantation Surgery, 1174

    104 Prophylaxis and Treatment of Kidney Transplant Rejection, 1186

    105 Medical Management of the Kidney Transplant Recipient: Infections and Malignancies, 1198

    106 Medical Management of the Kidney Transplant Recipient: Cardiovascular Disease and Metabolic

    Abnormalities, 1213

    107 Chronic Allograft Injury, 1226

    108 Recurrent Disease in Kidney Transplantation, 1236

    109 Outcomes of Renal Transplantation, 1247

    110 Pancreas and Islet Transplantation, 1258

    111 Kidney Disease in Liver, Cardiac, Lung, and Hematopoietic Stem Cell Transplantation, 1272

    SECTION XX Palliative Nephrology

    112 Palliative Nephrology, 1282

    Index, 1289

Product details

  • No. of pages: 1360
  • Language: English
  • Copyright: © Elsevier 2018
  • Published: June 26, 2018
  • Imprint: Elsevier
  • eBook ISBN: 9780323547192
  • Hardcover ISBN: 9780323479097

About the Authors

Richard Johnson

Affiliations and Expertise

Professor of Medicine, Division Chief, Tomas Berl Professor of Nephrology, University of Colorado–Denver, Denver, Colorado, USA

John Feehally

Affiliations and Expertise

Professor of Renal Medicine, The John Walls Renal Unit, Leicester General Hospital, Leicester, United Kingdom

Jurgen Floege

Affiliations and Expertise

Professor of Medicine, Director, Division of Nephrology and Clinical Immunology, RWTH University of Aachen, Aachen, Germany

Marcello Tonelli

Affiliations and Expertise

Associate Vice President of Health Research, University of Calgary, Senior Associate Dean of Clinical Research, Cumming School of Medicine, Professor of Medicine, University of Calgary, Calgary, Alberta, Canada

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