Description

Although many books exist on the subject of chiral chemistry, they only briefly cover chiral synthesis and analysis as a minor part of a larger work, to date there are none that pull together the background information and latest advances in one comprehensive reference work. Comprehensive Chirality provides a complete overview of the field, and includes chiral research relevant to synthesis, analytic chemistry, catalysis, and pharmaceuticals. The individual chapters in each of the 9 volumes provide an in depth review and collection of references on definition, technology, applications and a guide/links to the related literature. Whether in an Academic or Corporate setting, these chapters will form an invaluable resource for advanced students/researchers new to an area and those who need further background or answers to a particular problem, particularly in the development of drugs.

Key Features

  • Chirality research today is a central theme in chemistry and biology and is growing in importance across a number of disciplinary boundaries. These studies do not always share a unique identifying factor or subject themselves to clear and concise definitions. This work unites the different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding.
  •  The field of chirality counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Chirality fills this vacuum, and can be considered the definitive work. It will help users apply context to the diverse journal literature offering and aid them in identifying areas for further research and/or for solving problems.
  • Chief Editors, Hisashi Yamamoto (University of Chicago) and Erick Carreira (ETH Zürich) have assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource.

Readership

Graduate students and researchers working in organic, medicinal, and biological chemistry, as well as pharmacologists and toxicologists.

Table of Contents

Editors in Chief

Volume Editors

Preface

Permission Acknowledgments

Volume 1: Biological Significance: Pharmacology, Phamaceutical Agrochemical

1.1 Introduction: The Importance of Chirality in Drugs and Agrochemicals

Glossary

1.1.1 Drugs

1.1.2 Agrochemicals

References

1.2 Importance of Chirality in the Field of Anti-infective Agents

Glossary

1.2.1 Introduction

1.2.2 Antiinfectives from Natural Origin

1.2.3 Antiinfectives from Nonnatural Origin

1.2.4 Conclusion

Acknowledgments

References

1.3 Chirality in Antibacterial Agents

Glossary

1.3.1 Introduction

1.3.2 Membrane Synthesis Inhibitors

1.3.3 Antibacterial Agents Acting on DNA

1.3.4 Protein Synthesis Inhibitors

1.3.5 Molecules Acting on New Targets

1.3.6 Antibacterial Agents as Chiral Selectors

References

1.4 Diastereomers, Enantiomers and Bioactivity. TMC207: A New Candidate for the Treatment of Tuberculosis

Glossary

1.4.1 Introduction

1.4.2 Inhibition of ATP Synthase by TMC207

1.4.3 Chemistry

1.4.4 In Vitro Antimycobacterial Activity of TMC207

1.4.5 Conformational Analysis of TMC207

1.4.6 Molecular Basis and Stereospecificity

1.4.7 Conclusion

Acknowledgments

References

1.5 Fluorine in Medicinal Chemistry: Importance of Chirality

1.5.1 Introduction

1.5.2 Pharmaceuticals and Molecules of Biological Interest Bearing Fluorine and Trifluoromethyl Groups at an sp3-Hybridized Carbon

References

1.6 Peptides and Chirality Effects on the Conformation and the Synthesis of Medicinally Relevant Peptides

Glossary

1.6.1 Introduction

1.6.2 Chirality in Peptides from Amino Acids to Secondary Structures

1.6.3 Chirality in Peptide Turn Geometry and Nucleation of β

Details

No. of pages:
5648
Language:
English
Copyright:
© 2012
Published:
Imprint:
Elsevier Science
Electronic ISBN:
9780080951683
Print ISBN:
9780080951676