- Not Applicable ISBN 9780080951676
- Electronic ISBN 9780080951683
Although many books exist on the subject of chiral chemistry, they only briefly cover chiral synthesis and analysis as a minor part of a larger work, to date there are none that pull together the background information and latest advances in one comprehensive reference work. Comprehensive Chirality provides a complete overview of the field, and includes chiral research relevant to synthesis, analytic chemistry, catalysis, and pharmaceuticals. The individual chapters in each of the 9 volumes provide an in depth review and collection of references on definition, technology, applications and a guide/links to the related literature. Whether in an Academic or Corporate setting, these chapters will form an invaluable resource for advanced students/researchers new to an area and those who need further background or answers to a particular problem, particularly in the development of drugs.
- Chirality research today is a central theme in chemistry and biology and is growing in importance across a number of disciplinary boundaries. These studies do not always share a unique identifying factor or subject themselves to clear and concise definitions. This work unites the different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding.
- The field of chirality counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Chirality fills this vacuum, and can be considered the definitive work. It will help users apply context to the diverse journal literature offering and aid them in identifying areas for further research and/or for solving problems.
- Chief Editors, Hisashi Yamamoto (University of Chicago) and Erick Carreira (ETH Zürich) have assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource.
Graduate students and researchers working in organic, medicinal, and biological chemistry, as well as pharmacologists and toxicologists.
Volume 1: Biological significance - Pharmacology, Pharmaceutical, Agrochemical
Introduction: Importance of chirality in biological active compounds
Cases Where Chirality May or May Not be Critical in Drug Discovery and Development: Adventures with Protease Inhibitors
The new Phosphine Ligands in asymmetric synthesis
Chiral libraries for drug discovery, an overview
Issues of chirality in the synthesis of medicinally relevant peptides
Fluorine in Medicinal Chemistry
Synthesis of chiral antibacterial agents
Synthesis and biological activity of citalopram/escitalopram
Diastereo- and enantioselective syntheses of dioxolane and tetrahydrofurane
Volume 2: Synthetic Methods I - Chiral Pool and Diastereoselective Methods
Chiral pool syntheses | Chiral pool syntheses starting from amino acids
Chiral pool syntheses | Chiral pool syntheses starting from terpenes
Chiral pool syntheses | Chiral pool syntheses starting from carbohydrates
Chiral pool syntheses | Chiral pool syntheses from arene cis-1,2-diols
Chiral pool syntheses | Chiral pool synthesis from hydroxy acids: lactic acid, tartaric acid, malic acid, 2-methyl-3-hydroxypropionic acid
Chiral pool syntheses | Chiral pool synthesis from hydroxy acids: quinic acid
General Principles of Diastereoselective Reactions | Application of rigid templates and substrate directable reactions
General Principles of Diastereoselective Reactions | Acyclic conformational control of diastereoselectivity
General Principles of Diastereoselective Reactions | Domino reactions
Selected Diastereoselective reactions | carbanion additions to ketones and aldehydes
Selected Diastereoselective reactions | Aldoltyp
- No. of pages:
- © 2012
- 5th September 2012
- Elsevier Science
- Not Applicable ISBN:
- Electronic ISBN: