Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates

Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates

1st Edition - April 11, 2009

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  • Editor: David Hopwood
  • Hardcover ISBN: 9780123745910
  • eBook ISBN: 9780080923369

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Description

Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine.

Key Features

* Gathers tried and tested methods and techniques from top players in the field.
* Provides an extremely useful reference for the experienced research scientist.
* Covers biosynthesis of Polyketides, Tarpenoids, Aminocoumarins and Crabohydrates

Readership

Researchers in cell, molecular and developmental biology; biochemists, pharmacologists, geneticists.

Table of Contents

  • Part 1: Polyketides

    Overview of polyketide biosynthesis

    A) Type I

    Structural studies

    i) Iterative

    Fungal PKSs/FASs
    Polyunsaturated fatty acids (PUFAs)
    Enediynes

    ii) Modular

    Macrolides as a paradigm
    Macrolides - skipping and stuttering of modules
    Trans-AT class
    Polyethers
    Polyenes
    Polyketides in mycobacteria
    Docking of subunits
    Novel polyketides by genetic engineering
    De novo synthesis of pathway genes
    Precursor biosynthesis

    B) Type II

    In vitro analysis and engineering of novel compounds
    Bacterial fatty acid biosynthesis

    C) Type III

    In vitro / in vivo biochemical studies
    Structural studies

    Part 2: Terpenoids

    Enzymology and structural biology of terpenoid biosynthesis

    Part 3: Aminocoumarins

    Part 4: Carbohydrates

    Aminoglycosides
    Deoxysugar biosynthesis

Product details

  • No. of pages: 398
  • Language: English
  • Copyright: © Academic Press 2009
  • Published: April 11, 2009
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123745910
  • eBook ISBN: 9780080923369

About the Serial Volume Editor

David Hopwood

Affiliations and Expertise

John Innes Centre and AFRC Institute of Plant Science Research, Norwich, UK

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