SPEC – Combinational Therapy in Triple Negative Breast Cancer, 12-Month Access, eBook

SPEC – Combinational Therapy in Triple Negative Breast Cancer, 12-Month Access, eBook

1st Edition - April 28, 2022

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  • Author: Manzoor Mir
  • Paperback ISBN: 9780323961363
  • eBook ISBN: 9780323961370

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Table of Contents

  • Cover Image
  • Title Page
  • Copyright
  • Table of Contents
  • Contributors
  • About the author
  • Foreword
  • Preface
  • Acknowledgments
  • Chapter 1 Triple-negative breast cancer - an aggressive subtype of breast cancer
  • Introduction
  • Triple-negative breast cancer (TNBC)
  • TNBC histological classification
  • TNBC molecular classification
  • Triple-negative breast cancer risk factors and epidemiology
  • Current diagnostic options for triple-negative breast cancer
  • Future diagnostic options for TNBC
  • Triple-negative breast cancer’s prognostic implications
  • Somatic genomic mutations in TNBC
  • Epigenetic modifications in TNBC
  • Summary
  • References
  • Chapter 2 Novel biomarkers in triple-negative breast cancer - role and perspective
  • Introduction
  • EGFR
  • VEGF
  • PARP
  • Summary
  • References
  • Chapter 3 Current therapeutics and treatment options in TNBC
  • Introduction
  • Signaling pathways involved in triple-negative breast cancer (TNBC) treatment
  • Role of chemotherapeutic agents in TNBC
  • Surgery and radiotherapy
  • Targeted therapeutics for TNBC
  • Role of immunotherapy in the treatment of TNBC
  • Advanced treatment options for TNBC
  • Summary
  • References
  • Chapter 4 Conventional adjuvant chemotherapy in combination with surgery, radiotherapy, and other specific targets
  • Introduction
  • An overview of chemotherapy
  • Adjuvant chemotherapy: First, second, and third generation regimens
  • The case for chemotherapy in TNBC
  • Surgery in TNBC
  • Radiotherapy in TNBC
  • Chemotherapy combining specific target molecules in TNBC
  • EGFR
  • Summary
  • References
  • Chapter 5 Role of immune system in TNBC
  • Introduction
  • Cancer-immunity cycle
  • Immune system in cancer –a friend or FOE
  • Immune system and TNBC
  • Immune checkpoints in TNBC
  • Newly emerging immune checkpoints
  • TNBC metastasis and recurrence
  • Summary
  • References
  • Chapter 6 The interplay of immunotherapy, chemotherapy, and targeted therapy in tripple negative breast cancer (TNBC)
  • Introduction
  • An overview of immunotherapy in TNBC
  • Immunotherapy’s potential in TNBC: Variables to be considered
  • Choosing the proper immunotherapy and chemotherapy combination
  • Immune checkpoint blockades in TNBC
  • Combination treatments involving PD1/PD-L1
  • Adoptive cell therapy
  • Cancer vaccines
  • Resistance to ICI
  • Moving immunotherapy to early TNBC
  • Efficacy of immunotherapy and future perspectives in TNBC
  • Summary
  • References
  • Chapter 7 Targeting biologically specific molecules in triple negative breast cancer (TNBC)
  • Introduction
  • An overview of targeted therapy
  • Experimental targets for TNBC under study
  • Summary
  • References
  • Chapter 8 Different drug delivery approaches in combinational therapy in TNBC
  • Introduction
  • Nanocarriers as targeted drug delivery systems
  • Ligands for targeted TNBC treatment
  • VLPS (virus-like particles) as unique nanocarriers
  • Role of nanomedicine in breast cancer treatment: A transition from traditional to nanomedicine
  • Gene delivery
  • Photothermal therapy
  • Photodynamic therapy
  • Nanosoldiers to suppress TNBC metastasis
  • Stimulus responsive drug delivery
  • Summary
  • References
  • Glossary
  • Abbreviations
  • Index

Product details

  • Language: English
  • Copyright: © Academic Press 2022
  • Published: April 28, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323961363
  • eBook ISBN: 9780323961370

About the Author

Manzoor Mir

Manzoor Mir
Dr. Manzoor Ahmad Mir holds Master’s Degree in Zoology from HNBG Central University and after qualifying prestigious National level CSIR-JRF-NET examination he worked jointly for his Ph. D at Jawaharlal Nehru University New Delhi and CSIR-Institute of Microbial Technology Chandigarh in the field of Immunology. His basic research interests include Cancer Biology, Combination therapy in Breast Cancer, molecular immunology and Tuberculosis immunology. He has published more than 50 high-impact research papers and book chapters, in recognition of which he has received several awards and Royalties from international publishing houses. Dr. Manzoor has authored more than 15 books with international publishers like Elsevier USA and Nova Science Publisher USA, Bentham Sciences, IGI Global, Springer-Nature. He is on the editorial board and Reviewer of some prestigious journals like DOVE medical press, Springer Plus, Cancer Biomarkers, Frontiers, Plos etc and has been an invited speaker at various scientific meetings/conferences within India and abroad. He is member of many scientific organizations and societies like American Association of Cancer Research, Fellow of Royal British Society, International Immunology Association, Indian Cancer Society, Indian Immunology Society, Indian National Science Association, IMMUNOCON etc. Dr Manzoor was awarded Teachers Associate Research Excellence Fellowship (TARE) by DST Govt of India. He has been awarded Summer Research Fellowship Programme (SRFP-2019) by Indian Academy of Sciences and National Science Academy. He was awarded a research project on combination therapy in breast cancer by J&K Science Technology and Innovation. Dr Manzoor has developed Massive Open Online Course (MOOCs) in Immunology course and Endocrinology course for UG students sanctioned by UGC-Consortium for Educational Communication (CEC) SWAYAM Ministry of HRD Govt of India. He has research and teaching experience of 15 years. He currently teaches Cancer Biology, and Immunology at the Department of Bioresources, School of Biological Sciences, University of Kashmir. He is presently heading the Department of Bioresources, University of Kashmir.

Affiliations and Expertise

Department of Bioresources, School of Biological Sciences, University of Kashmir, Srinagar, India

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  • Aariz Sun Nov 07 2021

    Combinational Therapy in Triple Negative Breast Cancer

    This is a wonderful book describing all aspects of Tripple Negative Breast Cancer ( The aggressive subtype of breast Cancer). The book has been meticulously planned and Designed into various chapters which justifies the title. It describes the combination chemotherapeutic approaches in TNBC. I enjoyed the introduction of the book.