List of contributors. List of Participants. Preface. Acknowledgements. Section I. Circuitry for cognition and emotion. 1. The prefrontal cortex and the integration of sensory, limbic and autonomic information (H.J. Groenewegen, H.B.M. Uylings). 2. Neurobiological mechanisms of emotionally influenced, long-term memory (L. Cahill). 3. Hypothalamic connections with the cerebral cortex (C.B. Saper). 4. Functional neuroanatomy of the prefrontal cortex: autonomic interactions (C.G. Van Eden, R.M. Buijs). Section II. Attention and decision making. 5. Functional anatomy of arousal and attention systems in the human brain (T. Paus). 6. Attentional processes and learning and memory in rats: the prefrontal cortex and hippocampus compared (L.M. Broersen). 7. Limitations in information processing in the human brain: neuroimaging of dual task performance and working memory tasks (T. Klingberg). 8. Role of the prefrontal cortex of the rat in learning and decision making: effects of transient inactivation (J.P.C. De Bruin, M.G.P. Feenstra, L.M. Broersen, M. Van Leeuwen, C. Arens, S. De Vries, R.N.J.M.A. Joosten). Section III. Stress and reward systems in cognition. 9. The integration of stress by the hypothalamus, amygdala and prefrontal cortex: balance between the autonomic nervous system and the neuroendocrine system (R.M. Buijs, C.G. van Eden). 10. Dopamine and noradrenaline release in the prefrontal cortex in relation to unconditioned and conditioned stress and reward (M.G.P. Feenstra). 11. Locus coeruleus and regulation of behavioral flexibility and attention (G. Aston-Jones, J. Rajkowski, J. Cohen). 12. Stress impairs prefrontal cortical function in rats and monkeys: role of dopamine D1 and norepinephrine &agr;-1 receptor mechanisms (A.F.T. Arnsten). 13. Involvement of basal ganglia and orbitofrontal cortex in goal-directed behavior (J.R. Hollerman, L. Tremblay, W. Schultz). 14. Reward-dependent learning in neuronal networks for planning and decision-making (S. Dehaene, J.-P. Changeux). 15. The glutamate hypothesis of reinforcement learning (C.M.A. Pennartz, B.L. McNaughton, A.B. Mulder). 16. Interactions between medial prefrontal cortex and meso-limbic components of brain reward circuitry (R.A. Wise). 17. Limbic cortical-ventral striatal systems underlying appetitive conditioning (J.A. Parkinson, R.N. Cardinal, B.J. Everitt). 18. Plasticity of neuronal firing in deep layers of the medial prefrontal cortex in rats engaged in operant conditioning (A.B. Mulder, R. Nordquist, O. Örgüt, C.M.A. Pennartz). 19. Activity patterns in mesolimbic regions in rats during operant tasks for reward (D.J. Woodward, J.-Y. Chang, P. Janak, A. Azarov, K. Anstrom). Section IV. Mental disorders. 20.Reward deficiency syndrome: genetic aspects of behavioral disorders (D.E. Comings, K. Blum). 21. Evidence of fronto-thalamic involvement in schizophrenia ( M.M. Sitskoorn, M.C.M. Appels, H.E. Hulshoff Pol, R.S. Kahn). 22. The importance of a human 3D database and atlas for studies of prefrontal and thalamic functions (H.B.M. Uylings, E. Sanz Arigita, K. de Vos, W.J.A.J. Smeets, C.W. Pool, K. Amunts, G. Rajkowska, K. Zilles). 23. Interaction of prefrontal cortical and hypothalamic systems in the pathogenesis of depression (D.F. Swaab, E. Fliers, W.J.G. Hoogendijk, D.J. Veltman, J.N. Zhou). 24.Histopathology of the prefrontal cortex in major depression: what does it tell us about dysfunctional monoaminergic circuits? (G. Rajkowska). 25. Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression (W.C. Drevets). 26. Role for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drug action (J.D. Jentsch, R.H. Roth, J.R. Taylor). Section V.The integrative role of PFC in cognition, emotion and autonomic responses. 8th C.U. Ariëns Kappers lecture. 27. The fabric of the mind: a neurobiological perspective (A.R. Damasio). 28. From arousal to cognition: the integrative position of the prefrontal cortex (T.W. Robbins). This lecture was also presented by Dr. Antonio Damasio on 2 December 1999 at the eighth NWO/Huygens lecture, an initiative of the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), NRC Handelsblad and the City of The Hague. During this lecture Dr. Fernando H. Lopes da Silva acted as co-referent. Both lectures are included in the NWO/Huygens series and can be ordered from NWO:News@NWO.NL
Since the publication of the previous volume on the prefrontal cortex: its structures, function and pathology in Progress in Brain Research some ten years ago, new data has emerged on the prefrontal cortex and its connections and interactions with structures involved in emotional, motivational and autonomic responses. Cognition, memory and decision making appear to be influenced by emotional and autonomic responses from viscera and the internal state of the organism (e.g. 'gut feelings') induced by the outside world. This resulted in a renewed interest in the interactions of circuits involved in cognition, memory and decision making with those involved in emotional and motivational responses. Therefore, the 21st International Summer School of Brain Research, held in Amsterdam, 23-27 August 1999, was entirely devoted to the question to which extent the prefrontal cortex and related limbic structures function as an integrative center for these interactions.
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- © Elsevier Science 2000
- 8th November 2000
- Elsevier Science
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Netherlands Institute for Brain Research, Amsterdam, The Netherlands