Coenzyme B12 Enzymes Part A

Coenzyme B12 Enzymes Part A

1st Edition - June 1, 2022

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  • Editor: Neil Marsh
  • Hardcover ISBN: 9780323915915

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Description

B12 Enzyme, Volume 667 in the Methods in Enzymology serial, highlights new advances in the field with this new volume presenting timely, interesting chapters, including Part I: B12 Biosynthesis and B12 Chaperones, Probing the preference and regioselectivity of lower ligand activation and its role in cobamide diversity, Biosynthesis of corrinoids, The human B12 trafficking chaperones: CblC, CblD and ATR, A method for the efficient adenosylation of corrinoids, Production, purification and liposome reconstitution of cobamide synthase, Extraction and Purification of Cobamides from Bacterial Cultures, Part II: The many faces of B12-dependent enzyme reactions, Methylcobalamin-dependent methionine synthase, and much more.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in Methods in Enzymology serials
  • Includes the latest information on B12 Enzymes

Readership

Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Table of Contents

  • B12 Biosynthesis and B12 Chaperones

    1. Martin Warren University of Kent, U.K.

     Biosynthesis of corrinoids

    2. Amrita Hazra IISER Pune, India

     "Guardian of cobamide diversity: probing the role of CobT in lower ligand activation in the biosynthesis of vitamin B12 and other cobamide cofactors"

    3. Michiko Taga University of California, Berkeley

    " Purification and Detection of Vitamin B12 Analogs"

    4. Jorge Escalante-Semerena University of Georgia

    "A method for the efficient adenosylation of corrinoids"

    5. Jorge Escalante-Semerena University of Georgia

    "A method for the production, purification and liposome reconstitution of cobamide synthase"

    6. Jorge Escalante-Semerena University of Georgia

    "A method for the Isolation of -ribazole from Vitamin B12, and its Enzymatic Conversion to -ribazole 5’-phosphate"

    7. Ruma Banerjee University of Michigan

    "The human B12 trafficking chaperones: CblC, CblD and ATR"

    8. Bernhard Kräutler University of Innsbruck, Austria

    "Synthesis and applications of "antivitamin" B12 derivatives"

    B12-dependent enzyme reactions:

    9. Tetsuo Toraya Okayama University, Japan

    "Coenzyme B12-dependent eliminases: Diol and glycerol dehydratases and ethanolamine ammonia-lyase"

    10. Tetsuo Toraya Okayama University, Japan

    "Reactivating chaperones for coenzyme B12-dependent eliminases: Diol and glycerol dehydratases and ethanolamine ammonia-lyase"

    11. Wolfgang Buckel Marburg University

    "Glutamate mutase and 2-methyleneglutarate mutase"

    12. Ruma Banerjee University of Michigan

    "Human B12 dependent enzymes: Methionine synthase and methylmalonyl-CoA mutase"

    13. David Leys Manchester University

    "Heterologous production and biophysical characterisation of catabolic Nitratireductor pacificus pht-3B reductive dehalogenase"

    14. Nigel Scrutton Manchester University

    "An unusual light-sensing function for coenzyme B12 in bacterial transcription regulator CarH"

Product details

  • No. of pages: 390
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: June 1, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323915915

About the Serial Volume Editor

Neil Marsh

I am currently Professor of Chemistry and Biological Chemistry at the University of Michigan in Ann Arbor. My research interests center on enzyme mechanisms and protein structure and design. We are currently working on a variety of research projects. In particular, we have a long-standing interest in enzymes that use free radicals to catalyze a variety of unusual chemical transformations. More recently, we have become interested in enzymes involved in hydrocarbon biosynthesis, many of which have novel mechanisms and are of practical interest for the biosynthesis of next-generation biofuels. We are also interested in understanding in molecular detail how enzymes interact with abiological surfaces as this is key to many industrial and biomedical applications where enzymes are immobilized on solid supports. More information about my research can be found here:http://www.lsa.umich.edu/chem/people/faculty/ci.marsheneilg_ci.detail

Affiliations and Expertise

Dow Distinguished Faculty Fellow in Sustainability, Professor of Chemistry and Biological Chemistry, Department of Chemistry, University of Michigan, USA

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