1st Edition - October 26, 2009

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  • Editors: Saverio Bettuzzi, Sabina Pucci
  • Hardcover ISBN: 9780123747723
  • eBook ISBN: 9780080912257

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The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.


Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology.

Table of Contents

  • . Introduction

    Saverio Bettuzzi

    2. Clusterin (CLU): From One Gene and Two

    Transcripts to Many Proteins

    Federica Rizzi, Mariangela Coletta, and Saverio Bettuzzi

    3. The Shifting Balance Between CLU Forms

    During Tumor Progression

    Sabina Pucci and Saverio Bettuzzi

    4. Regulation of Clusterin Activity by Calcium

    Beata Pajak and Arkadiusz Orzechowski

    5. Nuclear CLU (nCLU) and the Fate of the Cell

    Saverio Bettuzzi and Federica Rizzi

    6. The Chaperone Action of Clusterin and Its Putative Role

    in Quality Control of Extracellular Protein Folding

    Amy Wyatt, Justin Yerbury, Stephen Poon,

    Rebecca Dabbs, and Mark Wilson

    7. Cell Protective Functions of Secretory

    Clusterin (sCLU)

    Gerd Klocks, Markus Baiersdo¨ rfer, and Claudia Koch-Brandt

    8. Clusterin: A Multifacet Protein at the Crossroad of

    Inflammation and Autoimmunity

    Ge´ raldine Falgarone and Gilles Chiocchia

    9. Oxidative Stress in Malignant Progression: The Role of Clusterin,

    A Sensitive Cellular Biosensor of Free Radicals

    Ioannis P. Trougakos and Efstathios S. Gonos

Product details

  • No. of pages: 350
  • Language: English
  • Copyright: © Academic Press 2009
  • Published: October 26, 2009
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123747723
  • eBook ISBN: 9780080912257

About the Serial Volume Editors

Saverio Bettuzzi

Sabina Pucci

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