Clinical Trials in Heart Disease

2nd Edition

A Companion to Braunwald's Heart Disease

Authors: JoAnn Manson Julie Buring Paul Ridker J. Michael Gaziano
Hardcover ISBN: 9780721604084
eBook ISBN: 9781437713084
Imprint: Saunders
Published Date: 4th June 2004
Page Count: 448

Description

This new edition covers important new trials in cardiology therapies and prevention of cardiovascular problems. The world authorities on pharmacologic clinical trials write about the trials, the outcomes and importance for clinical practice.
This book gives the general cardiologist insight into the development of new therapies in cardiology as well as the process of how trials were used for those therapies. In addition to providing a manual for how to establish trials, trials for treatment and prevention are covered.

Key Features

  • Evidence-based research to guide clinical practice.
  • Coverage of treatment trials including Glycoprotein IIb/IIa receptor inhibitors, aspirin, drug therapies for arrhythmias, and pacing.
  • Expanded section on prevention of cardiac disease
  • Covers both prevention and treatment.

Table of Contents

Section I. METHODOLOGY

Chapter 1: Contributions of Basic Research, Observational Studies, and Randomized Trials
Chapter 2: Methodology of Randomized Trials
Chapter 3: Comparative Features of Primordial, Primary and Secondary Prevention Trials
Chapter 4: Principles of Data and Safety Monitoring Boards in Randomized Trials

Section II. TREATMENT TRIALS

A. Treatment of Acute Coronary Ischemia

Chapter 5: Aspirin and Thienopyridines
Chapter 6: Heparin and Low Molecular Weight Heparin in Acute Coronary Ischemia
Chapter 7: Clinical Trials in Thrombolytic Therapy
Chapter 8: Clinical Trials of Direct Thrombin Inhibitors
Chapter 9: Glycoprotein IIb/IIIa Receptor Inhibitors
Chapter 10: Adjunctive Medical Therapy for Acute Myocardial Infarction
Chapter 11: Primary, Rescue and Adjunctive Mechanical Intervention in the Setting of Acute Myocardial Infarction
Chapter 12: Coronary Artery Bypass Surgery in Acute Coronary Syndromes

B. Treatment of Arrhythmias

Chapter 13: Drug Therapy for Ventricular Tachycardia and Ventricular Fibrillation
Chapter 14: Antiarrhythmic Drug Therapy in Supraventricular Tachycardia
Chapter 15: Anticoagulant and Antiplatelet Drug Therapy for Atrial Fibrillation
Chapter 16: Clinical Trials in Arrhythmia Ablation
Chapter 17: Clinical Trials of Implantable Cardioverter-Defibrillators (ICDs) and Cardiac Resynchronization Therapy/Defibrillation
Chapter 18: Clinical Trials in Pacing

C. Treatment of Congestive Heart Failure

Chapter 19: Drugs Blocking the Renin-Angiotensin-Aldosterone System (RAAS)
Chapter 20: Beta-blocker Treatment of Heart Failure
Chapter 21: Clinical Trials in Heart Transplantation and Mechanical Cardiac Support for End-Stage Heart Failure

Section III. PRIMARY AND SECONDARY PREVENTION TRIALS

Chapter 22: Cholesterol Reduction
Chapter 23: Blood Pressure Reductio

Details

No. of pages:
448
Language:
English
Copyright:
© Saunders 2004
Published:
Imprint:
Saunders
eBook ISBN:
9781437713084
Hardcover ISBN:
9780721604084

About the Author

JoAnn Manson

Affiliations and Expertise

Professor of Medicine, Harvard Medical School; Chief, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA

Julie Buring

Affiliations and Expertise

Professor of Ambulatory Care and Prevention, Harvard Medical School; Deputy Director, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA

Paul Ridker

Affiliations and Expertise

Associate Professor of Medicine, Harvard Medical School Director of the Center for Cardiovascular Disease Prevention, Director of Cardiovascular Disease Research, Co-Director of Blood Studies, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard School of Medicine, Brigham and Women’s Hospital, Boston, MA

J. Michael Gaziano

Affiliations and Expertise

Associate Professor of Medicine, Harvard Medical School, Co-Director of Cardiovascular Disease Research and Co-Director of Blood Studies, Division of Preventive Medicine, Brigham and Women's Hospital, Preventive Medicine Division, Boston, MA