Clinical Pharmacology During Pregnancy

1st Edition

Editors: Donald Mattison
Hardcover ISBN: 9780123860071
eBook ISBN: 9780123860088
Imprint: Academic Press
Published Date: 5th December 2012
Page Count: 488
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Clinical Pharmacology During Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy.

The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are covered, as are research issues, including clinical trial design and ethical considerations.

Key Features

  • Uses an evidence-based approach for therapeutics during pregnancy
  • Includes a summary of specific medications by indication with up-to-date information on dosing and efficacy in pregnancy for the given indication
  • Includes a companion website containing support materials for professional or continuing education courses in OB pharmacology


This book will be of value to anyone who is actively involved in the care of pregnant women, including obstetricians, residents in obstetrics, fellows in fetal maternal medicine, internists, general and family practitioners who provide care for women of reproductive age, pharmacists, midwives, nurse practitioners and physician assistants.

Table of Contents


1. Introduction


2. Physiologic Changes During Pregnancy

2.1 Physiologic changes during pregnancy

2.2 Cardiovascular system

2.3 Respiratory system

2.4 Renal system

2.5 Gastrointestinal system

2.6 Hematologic and coagulation systems

2.7 Endocrine system

2.8 Summary


3. Impact of Pregnancy on Maternal Pharmacokinetics of Medications

3.1 Introduction

3.2 Effects of pregnancy on pharmacokinetic parameters

3.3 Summary


4. Medications and the Breastfeeding Mother

4.1 Medication use by the breastfeeding mother

4.2 Clinical pharmacology of drug transfer into breast milk

4.3 During delivery

4.4 General anesthesia

4.5 Epidural anesthesia

4.6 Galactogogues

4.7 Immediate postpartum period

4.8 Pain

4.9 Methadone

4.10 Resumption of pre-pregnancy medications

4.11 Psycho- and neurotropic drugs

4.12 Drugs not to give to the nursing mother postpartum

4.13 Oral contraceptives (OCPs)

4.14 Summary

4.15 Where to find information


5. Fetal Drug Therapy

5.1 Introduction

5.2 Indications for fetal therapy

5.3 Strategies to achieve fetal drug therapy

5.4 Special considerations



6. Treating the Placenta: an Evolving Therapeutic Concept

6.1 Introduction

6.2 The placenta as the therapeutic target: the past

6.3 The placenta: therapeutic targets

6.4 The placenta as a therapeutic target today

6.5 The placenta as a therapeutic target in the future



7. What is Sufficient Evidence to Justify a Multicenter Phase 3 Randomized Controlled Trial in Obstetrics?

7.1 Introduction

7.2 Evidence, equ


No. of pages:
© Academic Press 2013
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editor

Donald Mattison

Affiliations and Expertise

Risk Sciences International, Ottawa Canada and University of Ottawa, Ottawa Canada


"This medications references is intended for medical and health professionals involved in the care of pregnant women…A companion website features case studies, slides, bulleted summaries, and questions."--Reference and Research Book News, August 2013