Section I: General considerations:
Classification of antihypertensive drugs and pharmacological considerations. Interaction of antihypertensive drugs with mechanisms of blood pressure regulation. Antihypertensive drugs: pharmacokinetics, pharmacodynamics, metabolism, side effects and drug interactions. Antihypertensive drugs: hemodynamic effects.
Section II: Diuretics:
Thiazides and loop diuretics. Aldosterone antagonists
Section III: Centrally acting drugs:
Methyldopa and imidazolone agonists.
Section IV: Vasodilator drugs:
Alpha-blocking drugs. Calcium channel blockers. Potent vasodilators.
Section V: Beta-blocking agents:
Beta-adrenoceptor blocking drugs.
Section VI: Drugs acting on the renin-angiotensin system:
Angiotensin converting enzyme inhibitors. Angiotensin receptor blockers. Vasopeptidase inhibitors.
Section VII: Future prospects:
Novel agents in development.
Section VIII: Clinical trials:
The evidence-base for treatment of hypertension.
Section IX: Therapeutic strategies:
Combination therapy. Sequential monotherapy.
Section X: Special patient groups:
Pregnancy. The elderly. Hypertension and diabetes. Ethnic considerations in hypertension.