Volume 25. Clinical Pharmacology and Therapeutics of Hypertension

1st Edition

Handbook of Hypertension Series


  • Print ISBN 9780444517579

Key Features

  • Volume in Handbook of Hypertension series.

  • International range of expert contributors.

  • Systematically reviews the clinical pharmacology of all the antihypertensive agents.

  • Also covers treatment of hypertension in special patient goups.

  • Includes covearge of latest clinical trials and prospects for the future.

Table of Contents

Section I: General considerations:

Classification of antihypertensive drugs and pharmacological considerations. Interaction of antihypertensive drugs with mechanisms of blood pressure regulation. Antihypertensive drugs: pharmacokinetics, pharmacodynamics, metabolism, side effects and drug interactions. Antihypertensive drugs: hemodynamic effects.

Section II: Diuretics:

Thiazides and loop diuretics. Aldosterone antagonists

Section III: Centrally acting drugs:

Methyldopa and imidazolone agonists.

Section IV: Vasodilator drugs:

Alpha-blocking drugs. Calcium channel blockers. Potent vasodilators.

Section V: Beta-blocking agents:

Beta-adrenoceptor blocking drugs.

Section VI: Drugs acting on the renin-angiotensin system:

Angiotensin converting enzyme inhibitors. Angiotensin receptor blockers. Vasopeptidase inhibitors.

Section VII: Future prospects:

Novel agents in development.

Section VIII: Clinical trials:

The evidence-base for treatment of hypertension.

Section IX: Therapeutic strategies:

Combination therapy. Sequential monotherapy.

Section X: Special patient groups:

Pregnancy. The elderly. Hypertension and diabetes. Ethnic considerations in hypertension.


No. of pages:
© 2008
Print ISBN:

About the author

Gordan McInnes

Affiliations and Expertise

Division of Cardiovascular and Medical Sciences, Gardiner Institute, Western Infirmary, Glasgow, UK Senior Lecturer/Honorary Consultant Physician