Clinical Neurophysiology of Infancy, Childhood, and Adolescence - 1st Edition - ISBN: 9780750672511, 9780702038600

Clinical Neurophysiology of Infancy, Childhood, and Adolescence

1st Edition

Authors: Gregory L. Holmes Solomon Moshé H. Royden Jones, Jr.
eBook ISBN: 9780702038600
Hardcover ISBN: 9780750672511
Imprint: Butterworth-Heinemann
Published Date: 22nd September 2005
Page Count: 888


This one-of-a-kind reference is unique in its exclusive devotion to the clinical neurophysiology of children. Written by a stellar group of recognized authorities, it blends classical electrophysiological techniques such as EEG, EMG, and nerve conduction studies with today's most cutting-edge methods, including magnetic stimulation and magnetoencephalography. The result is the first comprehensive review of all clinical neurophysiological techniques used to treat children with neurological disorders. This stand-alone text is essential to anyone performs or interprets neurophysiologic tests on children.

Key Features

  • Provides detailed correlations between clinical features and neurophysiological studies, as well as vital information on both common and rare neurological disorders.
  • Includes practical guidelines on interpreting neonatal and pediatric EEGs.
  • Details the use of magnetoencephalogrphy in the localization of cerebral function.
  • Features intracranial EEG monitoring in the evaluation of children with medically intractable epilepsy.
  • Explores the neurophysiology of language and behavioral disorders in children.
  • Addresses intraoperative evoked potentials as a means of gathering subtle clinical information.
  • Discusses the interrelation of DNA analysis and clinical neurophysiology in the diagnosis of chronic neuromuscular disorders of childhood.
  • Examines the neurophysiological root of frequently encounter pediatric sleep disorders.
  • Presents concise descriptions of the neurological disorders in which clinical neurophysiological testing is valuable.
  • Organizes information in an easy-to-find, clinically relevant manner.

Table of Contents


Basic Principles and Maturational Change

1. Basic Principles of Electroencephalography

2. Electroencephalography of the Newborn: Normal Features

3. Visual Analysis of the Neonatal Electroencephalogram

4. Normal Development of the Electroencephalogram: Infancy Through

5. Visual Analysis of the Pediatric Electroencephalogram

6. Clinical Neurophysiology of the Motor Unit in Infants and Children

7. Maturational Changes vis-à-vis Neurophysiology Markers and the
Development of Peripheral Nerves

8. Somatosensory Evoked Potentials in Pediatrics—Normal

9. Brainstem Auditory Evoked Potentials in Pediatrics—Normal

10. Visual Evoked Potentials in Pediatrics—Normal


Disorders of Cerebral Function

11. Age-Specific Seizure Disorders

12. Neurophysiology of Language and Behavioral Disorders in Children

13. Neonatal Electroencephalography: Abnormal Features

14. Drug Effects on the Human Electroencephalogram

15. Electroencephalography and Structural Disease of the Brain

16. Manifestations of Metabolic, Toxic, and Degenerative Diseases

17. Infectious Diseases

18. Head Trauma

19. Childhood Sleep-Wake Disorders

20. The Diagnosis of Brain Death

21. Ambulatory Electroencephalography

22. Electroencephalography in Evaluation for Epilepsy Surgery in Children

23. Long-Term Electroencephalogram and Video Monitoring

24. Intraoperative Neurophysiologic Monitoring Using Evoked Potentials

Abnormal Evoked Potentials

25. Somatosensory Evoked Potentials in Pediatrics—Abnormal

26. Brainstem Auditory Evoked Potentials in Pediatrics—Abnormal

27. Visual Evoked Potentials in Pediatrics—Abnormal


Neuromuscular Disorders

28. The Floppy Infant

29. Facial and Bulbar Weakness

30. Spinal Muscular Atrophies and Other Disorders of the Anterior Horn Cell

31. Plexopathies and Nerve Root Lesions

32. Focal Neuropathies in Children

33. Clinical Neurophysiology of Pediatric Polyneuropathies

34. Autonomic Testing in Childhood

35. Neuromuscular Transmission Defects

36. Muscle Disorders in Children: Neurophysiologic Contributions to
Diagnosis and Management

37. Neuromuscular Problems of the Critically Ill Neonate, Child, and Adolescent

38. The Interrelation of DNA Analysis with Clinical Neurophysiology in the Diagnosis of
Chronic Neuromuscular Disorder of Childhood


Other Neurophysiologic Techniques

39. Magnetoencephalography (MEG)

40. Transcranial Magnetic Stimulation: An Overview

41. Sphincter Dysfunction



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About the Author

Gregory L. Holmes

Affiliations and Expertise

Professor of Neurology, Harvard Medical School, Boston; Director, Division of Clinical Neurophysiology and Epilepsy, Children's Hospital, Boston, MA

Solomon Moshé

Dr. Moshé is a professor of neurology, neuroscience, and pediatrics at Albert Einstein College of Medicine. He is the Director of Child Neurology and Clinical Neurophysiology and the recipient of a Martin A. and Emily L. Fisher fellowship in Neurology and Pediatrics at Albert Einstein. Dr. Moshé received his M.D. from the National University of Athens School of Medicine, Athens, Greece in 1972. He trained in pediatrics at the University of Maryland and in neurology at Albert Einstein. Since 1979, his research has focused on understanding the mechanisms underlying age-related differences in epilepsy in humans and in animal models. During the last ten years, his interest has turned to elucidating the subcortical circuitry involved in the control of seizures as a function of age and the consequences of seizures on the developing brain.

Affiliations and Expertise

Albert Einstein College of Medicine, Bronx, NY, USA

H. Royden Jones, Jr.

Dr. H. Royden Jones was Chair of the Department of Neurology at Lahey Hospital and Medical Center, Burlington, Massachusetts; Director of the Electromyography Laboratory at Boston Children’s Hospital; and Clinical Professor of Neurology at Harvard Medical School. Dr. Jones completed residencies in Internal Medicine and Neurology and a fellowship in neurological physiology at the Mayo Clinic. He served over 3 years in the United States Army as Chief of Neurology at 5th General Hospital, Bad Cannstatt, Germany. Dr. Jones was Board certified in neurology, clinical neurophysiology, and neuromuscular medicine. Upon completion of his training he joined the Lahey Clinic in 1972. In 1977 he also joined the neurology department at Boston Children’s Hospital, founding the electromyography laboratory in 1979. Pediatric EMG became his major clinical research interest. Dr. Jones was co-editor of three major textbooks on childhood clinical neurophysiology and neuromuscular disorders. He was a co-founder of the biennial International Paediatric EMG Conference based at Great Ormond Street Children’s Hospital, London, England. Recognized as one of the top neurologists in the U.S., Dr. Jones was an author and editor of several Netter publications including two editions of Netter’s Neurology, The Netter Collection of Medical Illustrations: Nervous System, Volume 7, Part I (Brain) and Part II (Spinal Cord and Peripheral Motor and Sensory Systems), 2nd Editions (volumes in the Netter Green Book Collection). Dr. Jones authored and edited several other Netter publications and contributed over 200 peer-reviewed papers and book chapters. Dr. Jones served 8 years as a director of the American Board of Psychiatry and Neurology, becoming Chair of its Neurology Council in 2004. In 2007 he received the Distinguished Physician Award from the American Association of Neuromuscular and Electrodiagnostic Medicine. Lahey Clinic’s Medical Staff Association recognized Dr. Jones in 2010 with its highest honor—the Frank Lahey Award for “commitment to the values of Dr. Frank Lahey: respect, teamwork, excellence, commitment to personal best.” Dr. Jones was named Outstanding Teacher in Pediatric Neurology 2012 – 2013 by the Department of Neurology, Boston Children’s Hospital, Harvard Medical School. He also received an award in recognition of his many years of dedicated teaching at Tufts University School of Medicine.

Affiliations and Expertise

Children's Hospital, Boston, MA, USA