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Clinical Neurophysiology: Basis and Technical Aspects - 1st Edition - ISBN: 9780444640321, 9780444640338

Clinical Neurophysiology: Basis and Technical Aspects, Volume 160

1st Edition

Handbook of Clinical Neurology Series

Series Volume Editors: Kerry Levin Patrick Chauvel
eBook ISBN: 9780444640338
Hardcover ISBN: 9780444640321
Imprint: Elsevier
Published Date: 3rd July 2019
Page Count: 622
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Table of Contents

Section 1. Basic Physiological and Recording Concepts
1. Generation and propagation of the action potential
2. Volume conduction, waveform analysis, and near and far field potentials
3. Instrumentation for electrodiagnostic studies
4. Filtering of neurophysiological signals
5. Electrical safety

Section 2. EEG: Technologic Aspects and Basic Rhythms
6. EEG source localization
7. Adult EEG
8. Child EEG (and maturation)
9. Normal EEG variants
10. Ambulatory EEG
11. Video-EEG
12. High-resolution EEG
13. Magnetoencephalography for localizing and characterizing the epileptic focus

Section 3. Nerve Conduction Studies, Methods and Techniques
14. Nerve conduction studies: Basic concepts
15. F wave, A wave, H reflex, and blink reflex

Section 4. Needle Electromyography, Methods and Techniques
16. Needle electromyography: basic concepts
17. Normal and abnormal spontaneous activity
18. Normal and abnormal voluntary activity
19. Single fiber EMG

Section 5. Intra-operative Clinical Neurophysiology, MEP, SSEP
20. Electrocorticography and functional mapping
21. Spinal cord monitoring
22. Electrophysiological mapping for deep brain stimulation for movement disorders

Section 6. Sleep Physiology and Studies
23. Sleep-wake physiology
24. Practical aspects of actigraphy and approaches in clinical and research domains
25. Polysomnography
26. The Multiple sleep latency test

Section 7. Autonomic Nervous System: Basic and Technical Aspects
27. Basics of autonomic nervous system function
28. Autonomic testing, methods and techniques

Section 8. Auditory, Visual and Somatosensory Evoked Potentials
29. Cochlea and auditory nerve
30. Auditory brainstem response
31. The auditory and association cortex and language evaluation methods
32. Electroretinograms
33. The Electrooculogram
34. Visually evoked potentials
35. Somatosensory evoked potentials

Section 9. Cognitive Neurophysiology
36. Cognitive neurophysiology: event-related potentials
37. Transcranial magnetic stimulation


Clinical Neurophysiology: Basis and Technical Aspects, the latest release in the Handbook of Clinical Neurology series, is organized into sections on basic physiological concepts, on the function and limitations of modern instrumentation, and on other fundamental or methodologic aspects related to the recording of various bioelectric signals from the nervous system for clinical or investigative purposes. There is discussion of the EEG, nerve conduction studies, needle electromyography, intra-operative clinical neurophysiology, sleep physiology and studies, the autonomic nervous system, various sensory evoked potentials, and cognitive neurophysiology.

Key Features

  • Provides an up-to-date review on the practice of neurophysiological techniques in the assessment of neurological disease
  • Explores the electrophysiological techniques used to better understand neurological function and dysfunction, first in the area of consciousness and epilepsy, then in the areas of the peripheral nervous system and sleep
  • Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, magnetoencephalography, laser evoked potentials, and transcranial magnetic stimulation


Basic and clinical researchers in neuroscience and neurophysiology; fellows, residents, and practicing clinicians in neurology, clinical neurophysiology, sleep medicine, subspecialists in epilepsy, neuromuscular diseases


No. of pages:
© Elsevier 2019
3rd July 2019
eBook ISBN:
Hardcover ISBN:


"For individuals who are looking for a concise, but in depth, review of a specific neurophysiological technique, this is the text for you. Editors Levin and Chauvel provide a thoughtful examination of the technical characteristics of a variety of neurophysiological techniques. There do not appear to have been any corners cut in describing the technical aspects of each measurement procedure. As a whole, the volume represents a significant advancement to the rapidly evolving field of clinical neurophysiology." -- Applied Neuropsychology-Adult, April 2020

Ratings and Reviews

About the Series Volume Editors

Kerry Levin

Dr. Levin began his position at Cleveland Clinic in 1984 as a neurologist and currently serves in multiple capacities, including Chair of the Department of Neurology, Director of the Neuromuscular Center at the Neurological Institute, Program Director for neurophysiology and neuromuscular fellowships and Professor at the Cleveland Clinic Lerner College of Medicine, Case Western Reserve University. Twice awarded Teacher of the Year by the Neurology Department, Dr. Levin's specialties are electromyography and clinical neuromuscular diseases. Dr. Levin is a fellow of the American Academy of Neurology and of the American Association of Electrodiagnostic Medicine, and his been elected to membership in the American Neurological Association. He has held leadership positions in these and other professional associations and sits on the editorial board of Muscle and Nerve. The author of several books and many articles, Dr. Levin is also engaged in clinical research with interests ranging from the electrodiagnosis of radiculopathy and defects of neuromuscular junction transmission, to the treatment of polyneuropathy.

Affiliations and Expertise

Chair, Department of Neurology, Director of the Neuromuscular Center at the Neurological Institute, Cleveland Clinic, Cleveland, OH, USA

Patrick Chauvel

After becoming an INSERM (Paris) researcher, Pr. Chauvel began his work in experimental and later clinical research into the mechanisms of the epilepsies. Under the mentorship of Talairach and Bancaud at Hopital Sainte-Anne, Paris, he developed SEEG (StereoElectroEncephalography) as a presurgical method in epilepsy surgery. His research work has been devoted to the neurophysiology of the epileptogenic zone, emergence of seizure clinical semiology in relation to intracerebral recording, and cerebral cortex physiology. He has promoted the concept of epileptogenic network over the classical epileptic focus idea, and opened new vistas in markers of the epileptogenic zone and pathophysiology of frontal epilepsies. Pr. Chauvel served as the Director of the SEEG Unit in Hôpital Sainte-Anne in Paris (1986-1990), then Professor and Chairman of Neurology in Rennes (1990-1997) where he configured a new type of Epilepsy Unit including research, then Professor and Chairman of Clinical Neurophysiology and Director of the INSERM Institute of Systems Neuroscience in Marseille (1997-2014). In 2014, he relocated to the Epilepsy Center of the Cleveland Clinic, in order to promote the development of presurgical investigation using SEEG in North America. He is the author of 250 original articles in international journals and is a member of several Scientific and Medical Societies, both French and International. He has been elected as a Member of the Belgian Royal Academy of Medicine.

Affiliations and Expertise

Staff Neurologist in the Epilepsy Center at the Neurological Institute, Cleveland, OH, USA