Clinical Neuroendocrinology

Clinical Neuroendocrinology

1st Edition - January 1, 1977

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  • Editor: Luciano Martini
  • eBook ISBN: 9780323144292

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Clinical Neuroendocrinology covers the clinical significance of the advances made in the understanding of relationships between the actions of neurotransmitters and the hypothalamic control of pituitary secretions. This book contains 24 chapters that examine the interactions of target gland secretions with the effects of hypothalamic and pituitary hormones. This book begins with a discussion of the physiological regulation and clinical applications of thyrotropin-stimulating hormone and thyrotropin-releasing hormone. The subsequent chapters are devoted to neuroendocrine aspects, secretion, regulation, and analysis of gonadotropin and gonadotropin-releasing hormone. Other chapters explore the regulations, tests, therapeutic implications, and clinical physiology of growth hormones and prolactin. This text also considers the chemical nature, brain pathways, mode of action, and clinical significance of other hormones, including corticotropin-releasing factor, melanocyte-stimulating hormone release-inhibiting factor, melanocyte-stimulating hormone, and related pituitary peptides. The remaining chapters examine the control mechanisms and pathophysiology of vasopressin, oxytocin, and neurophysins. Clinical neuroendocrinologists and researchers will find this book of great value.

Table of Contents

  • List of Contributors


    Chapter 1 Physiology and Nature of Hypothalamic Regulatory Hormones

    I. General Introduction

    II. Corticotropin-Releasing Factor (CRF)

    III. Thyrotropin-Releasing Hormone (TRH)

    IV. The LH- and FSH-Releasing Hormone (LH-RH/FSH-RH)

    V. Prolactin Release-Inhibiting Factor (PIF)

    VI. Prolactin-Releasing Factor (PRF)

    VII. Growth Hormone Release-Inhibiting Hormone (GH-RIH; Somatostatin)

    VIII. Growth Hormone-Releasing Factor (GH-RF)

    IX. Melanocyte-Stimulating Hormone Release-Inhibiting Factor (MIF)


    Chapter 2 Role of Central Cholinergic and Aminergic Neurotransmitters in the Control of Anterior Pituitary Hormone Secretion

    I. Introduction

    II. Role of Cholinergic Neurotransmitters

    III. Role of Catecholaminergic Neurotransmitters

    IV. Role of Indoleaminergic Neurotransmitters

    V. Conclusions


    Chapter 3 TSH and TRH: Their Physiological Regulation and the Clinical Applications of TRH

    I. Normal TSH Control, TSH Rhythm, and Nature of Feedback

    II. The TRH Test

    ΙII. Other Test Procedures for TSH Reserve


    Chapter 4 TRH: Clinical Investigations for Nonendocrine Actions in Man

    I. Introduction

    II. Mental Depression

    III. TSH Response in Mental Depression

    IV. Miscellaneous Clinical Trials with TRH

    V. Summary


    Chapter 5 Normal Gonadotropin Secretion in Females

    I. Episodic Secretion of Pituitary Gonadotropins

    II. Circadian Studies of Pituitary Gonadotropin Secretion

    III. Gonadotropin Secretion during the Normal Menstrual Cycle

    IV. Ovarian Steroid Secretion during the Normal Menstrual Cycle

    V. Temporal Relationships between Ovarian Steroids and Gonadotropins at Midcycle

    VI. The Reciprocal Relationship between the Ovarian Hormones and the Pituitary Gonadotropins

    VII. Hormonal Changes during Menstrual Cycles in the Premenopausal Period

    VIII. Gonadotropin Secretion before and after Menopause

    IX. Effects of Exogenous Sex Steroids on the Pituitary Gonadotropin Secretion in Women

    X. Effect of Synthetic Sex Steroids on Gonadotropin Secretion during the Menstrual Cycle

    XI. Effects of Clomiphene Citrate on the Pituitary Gonadotropin Secretion in Normal Women

    XII. Effects of Exogenous Gonadotropin-Releasing Hormone in Normal Women during the Menstrual Cycle

    XIII. Present Concept of the Regulation of the Human Menstrual Cycle


    Chapter 6 Neuroendocrine Aspects of the Regulation of Cyclic Gonadotropin Release in Women

    I. Introduction

    II. The Three-Component System

    III. Clinical Aspects

    IV. Summary


    Chapter 7 Gonadotropin Secretion in Male Subjects

    I. Introduction

    II. Gonadotropin Secretion at Different Stages of Life in the Male

    III. Regulation of Gonadotropin Secretion in Males

    IV. Conclusions


    Chapter 8 Gonadotropin-Releasing Hormone

    I. Introduction

    II. Gn-RH in Normal Subjects

    III. Gn-RH in Pathological States

    IV. Gn-RH Therapy


    Chapter 9 Test Procedures for Gonadotropin Reserve Other than Gn-RH

    I. Introduction

    II. Mechanisms of Action of Clomiphene

    III. Clinical Use of Clomiphene

    IV. 2-Hydroxyestrone


    Chapter 10 Growth Hormone

    I. Introduction

    II. Regulation of Growth Hormone Secretion

    III. Tests of Growth Hormone Secretion

    IV. Disordered Growth Hormone Secretion


    Chapter 11 Growth Hormone Release-Inhibiting Hormone (GH-RIH, Somatostatin)

    I. Introduction

    II. Localization

    III. Mechanism of Action

    IV. Actions on Pituitary Function

    V. Actions on Extrapituitary Hormones

    VI. Therapy


    Chapter 12 Therapeutic Implications of Dopaminergic Drugs in Acromegaly

    I. Introduction

    II. GH Secretion and Neurotransmitters

    III. Medical Therapy for Acromegaly


    Chapter 13 Nature of Prolactin and Its Measurement

    I. Introduction

    II. Purification and Characterization

    III. Measurement of Prolactin

    IV. The Form of Prolactin in Serum

    V. Comparison of Methods


    Chapter 14 Prolactin: Clinical Physiology and the Significance and Management of Hyperprolactinemia

    I. Introduction

    II. Secretory Patterns

    III. Normal Control of Prolactin Secretion

    IV. Physiological Role of Prolactin

    V. Dynamic Tests for Prolactin Secretion

    VI. Disorders of Prolactin Secretion

    VII. Mechanisms of Hypogonadism in Hyperprolactinemia

    VIII. Conclusions


    Chapter 15 The Nature of CRF and Its Relationship to Vasopressin

    I. Introduction

    II. Chemical Nature of Vasopressin and CRF

    III. Dissimilarity of Vasopressin and CRF: In Vitro Studies

    IV. Brain Pathways and ACTH Regulation

    V. Response to Vasopressin Administration in Normal Subjects

    VI. Vasopressin as a Test of Hypothalamic-Pituitary (ACTH) Function

    VII. Response to Vasopressin Administration in Patients Receiving Corticosteroid

    VIII. Response to Vasopressin Administration in Patients with Cushing's Disease or Syndrome


    Chapter 16 MIF-I: Actions in Man

    I. Introduction

    II. Parkinson's Disease

    III. Mental Depression

    IV. Tardive Dyskinesia

    V. MSH Release

    VI. Summary


    Chapter 17 Human Adrenocorticotropin and Lipotropin (MSH) in Health and Disease

    I. Introduction

    II. Nature of ACTH and Related Peptides

    III. Measurement of ACTH

    IV. Physiological Mechanisms Controlling ACTH Secretion

    V. Assessment of Basal ACTH Secretion

    VI. Dynamic Tests of ACTH Secretion

    VII. ACTH and Cushing's Syndrome

    VIII. ACTH and Adrenocortical Failure

    IX. Nature of ß-LPH, γ-LPH, and ß-MSH

    X. Measurement of ß-LPH, γ-LPH, and ß-MSH

    XI. Physiology and Pathophysiology of ßh-LPH Secretion: Relationship to MSH

    XII. ACTH and ß-LPH-Related Peptides in the Fetus

    XIII. The Endorphins


    Chapter 18 Central Nervous System Actions of MSH and Related Pituitary Peptides

    I. Introduction

    II. Behavioral Studies with Rats

    III. Behavioral Studies with Human Beings

    IV. Other CNS Effects of MSH and ACTH Analogues

    V. Discussion


    Chapter 19 Measurement of Hypothalamic Regulatory Hormones in Biological Systems

    I. General Principles

    II. Biological Assays

    III. Radioimmunoassays and Receptor Assays

    IV. Problems Associated with Assays in Biological Fluids

    V. Significance of Assay Results

    VI. Conclusions


    Chapter 20 The Neuroendocrine System and Puberty

    I. Neuroendocrine Control of Gonadotropins before Puberty

    II. Puberal Maturation of Neuroendocrine Control

    III. Neuroendocrine Control in Pathological Conditions

    IV. Concluding Comments


    Chapter 21 Pathological States Involving the Pineal

    I. Neuroanatomy and Cytology of the Pineal

    II. Synthesis and Metabolism of Melatonin

    III. Physiology of the Pineal Organ

    IV. Biological Effects of Pineal Compounds

    V. Pineal Pathology


    Chapter 22 Vasopressin

    I. Introduction

    II. Nature

    ΙΠ. Control Mechanisms

    IV. Neurotransmitters

    V. Effects of Vasopressin

    VI. Drug Interactions

    VII. Pathophysiology

    VIII. Conclusions


    Chapter 23 Oxytocin

    I. Introduction

    II. The Nature of Oxytocin

    III. The Synthesis and Release of Oxytocin

    IV. The Control of Oxytocin Release

    V. The Measurement of Oxytocin

    VI. Function of Oxytocin in Labor

    VII. Function of Oxytocin in Lactation

    VIII. Other Functions of Oxytocin

    IX. Disorders Involving Oxytocin Secretion


    Chapter 24 Neurophysins

    I. Introduction

    II. Oxytocin Neurophysin and Vasopressin Neurophysin

    III. Human Neurophysins: Nicotine-Stimulated Neurophysin (NSN) and Estrogen-Stimulated Neurophysin (ESN)

    IV. Conclusions


Product details

  • No. of pages: 628
  • Language: English
  • Copyright: © Academic Press 1977
  • Published: January 1, 1977
  • Imprint: Academic Press
  • eBook ISBN: 9780323144292

About the Editor

Luciano Martini

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