Clinical Molecular Medicine

Clinical Molecular Medicine

Principles and Practice

1st Edition - November 30, 2019

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  • Editor: Dhavendra Kumar
  • Hardcover ISBN: 9780128093566

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Description

Clinical Molecular Medicine: Principles and Practice presents the latest scientific advances in molecular and cellular biology, including the development of new and effective drug and biological therapies and diagnostic methods. The book provides medical and biomedical students and researchers with a clear and clinically relevant understanding on the molecular basis of human disease. With an increased focus on new practice concepts, such as stratified, personalized and precision medicine, this book is a valuable and much-needed resource that unites the core principles of molecular biology with the latest and most promising genomic advances.

Key Features

  • Illustrates the fundamental principles and therapeutic applications of molecular and cellular biology
  • Offers a clinically focused account of molecular heterogeneity
  • Includes comprehensive coverage of many different disorders, including growth and development, cardiovascular, metabolic, skin, blood, digestive, inflammatory, neuropsychiatric disorders, and many more

Readership

Medical and biomedical students, clinicians and scientists who are expected to have a clear and clinically relevant understanding of the molecular basis of human disease to practice evidence-based clinical medicine

Table of Contents

  • Part I. FUNDAMENTALS OF MOLECULAR MEDICINE
    1. The human genome and molecular medicine
    2. Cellular structure and molecular cell biology
    3. Molecular basis of clinical metabolomics
    4. Clinical applications of next-generation sequencing

    Part II. MOLECULAR MEDICINE IN CLINICAL PRACTICE
    5. Molecular basis of obesity disorders
    6. Molecular dysmorphology
    7. Disorders of sex development
    8. Molecular systems in cardiovascular developmental disorders
    9. Channelopathies in clinical medicine—cardiac arrhythmias
    10. Chronic heart failure
    11. Molecular pathophysiology of systemic hypertension
    12. Molecular basis of stroke
    13. Clinical molecular endocrinology
    14. Genetic disorders of lipoprotein metabolism
    15. Molecular medicine of diabetes mellitus
    16. Molecular genetic management of epilepsy
    17. The human leukocyte antigen system in human disease and transplantation medicine
    18. Disorders of abnormal hemoglobin
    19. Coagulation and bleeding disorders
    20. Molecular and genomic basis of bronchial asthma
    21. Molecular systems in inflammatory bowel disease
    22. Molecular biology of acute and chronic inflammation
    23. Molecular basis of susceptibility and protection from microbial infections
    24. Molecular mechanisms in cancer susceptibility—lessons from inherited cancers
    25. Clinical molecular nephrology—acute kidney injury and chronic kidney disease
    26. Molecular basis of chronic neurodegeneration
    27. Molecular basis of movement disorders
    28. Molecular pathology in neuropsychiatric disorders
    29. Targeted molecular therapy: the cancer paradigm
    30. Gene, genome, and molecular therapeutics
    31. Personalizing medicine with pharmacogenetics and pharmacogenomics
    32. Integrated genomic and molecular medicine

Product details

  • No. of pages: 606
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: November 30, 2019
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128093566

About the Editor

Dhavendra Kumar

Professor Kumar has considerable previous experience in writing and editing books and journals related to genetics and genomics. His books include Genomics and Clinical Medicine and Genomics and Health in the Developing World. He founded and leads the new open access journal Applied and Translational Genomics, published by Elsevier. He has published 40 articles in the journals literature.

Professor Dhavendra Kumar is a Visiting Professor, Genomic Policy Unit, Faculty of Life Sciences and Education, The University of South Wales and Consultant in Clinical Genetics at the University Hospital of Wales, Institute of Medical Genetics, Cardiff University, Cardiff, United Kingdom. He is one of the Consultants for the All Wales Medical Genetics Service and the lead Clinician for Clinical Cardiovascular Genetics. After qualifying in Medicine from the King George’s Medical College, University of Lucknow, India, he completed postgraduate training in Pediatrics with an MD. Since 1980 he has pursued a career in Medical Genetics in the UK. In 1990 he became a Diplomate of the American Board of Medical Genetics. He is a Fellow of the American College of Medical Genetics (FACMG) and as well as Royal Colleges of Physicians (FRCP-London and FRCP-Ireland) and Pediatrics and Child Health (FRCPCH-UK).

In 2015, he was conferred with the higher degree of DSc by his Alma Mater, King George’s Medical University, Lucknow (UP, India) based on his life-time contributions and achievements to genetic and genomic applications in medicine and health.

Affiliations and Expertise

Visiting Professor, Genomic Policy Unit, Faculty of Life Sciences and Education, The University of South Wales, UK; Consultant in Clinical Genetics at the University Hospital of Wales, Institute of Medical Genetics, Cardiff University, Cardiff, UK

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