Clinical Immunology

4th Edition

Principles and Practice

Print ISBN: 9780723436911
eBook ISBN: 9780723437109
Imprint: Saunders
Published Date: 12th December 2012
Page Count: 1323


Offer your patients the best possible care with clear, reliable guidance from one of the most respected and trusted resources in immunology. Authoritative answers from internationally renowned leaders in the field equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems.

"This is a 'must have' book for any serious student of clinical immunology...I heartily recommend this book."
Reviewed by: Dr Andy Gennery on behalf of the British Journal of Immunology, December 2013

Key Features

  • Depend on authoritative information from leading experts in the field who equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems.
  • Focus on the information that’s most relevant to your daily practice through a highly clinical focus and an extremely practical organization that expedites access to the answers you need.
  • Stay at the forefront of your field with cutting-edge coverage of the human genome project, immune-modifier drugs, and many other vital.


Table of Contents

PART 1: Fundamental Principles of the Immune Response

1 The human immune response
2 Organization of the immune system
3 Innate immunity
4 Antigen receptor genes, gene products, and co-receptors
5 The major histocompatibility complex
6 Antigens and antigen processing
7 Antigen-presenting cells and antigen presentation
8 B-cell development and differentiation
9 T-cell development
10 Cytokines and cytokine receptors
11 Chemokines and chemokine receptors
12 Lymphocyte adhesion and trafficking
13 T-cell activation and tolerance
14 Programmed cell death in lymphocytes

PART 2: Host Defense Mechanisms and Inflammation

15 Immunoglobulin function
16 Regulatory T cells
17 Helper T-cell subsets and control of the inflammatory response
18 Cytotoxic lymphocyte function and natural killer cells
19 Host defenses at mucosal surfaces
20 Complement and complement deficiencies
21 Phagocytes and phagocyte deficiencies
22 Mast cells, basophils and mastocytosis
23 Eosinophils and eosinophilia

PART 3: Infection and Immunity

24 Immune response to extracellular bacteria
25 Immune responses to intracellular bacteria
26 Immune responses to spirochetes
27 Immune responses to viruses
28 I mmune responses to protozoans
29 Immune responses to helminths

PART 4: Immunologic Deficiencies

30 Evaluation of the immunodeficient patient
31 Infections in the immunocompromised host
32 Development of the fetal and neonatal immune system
33 Aging and the immune system
34 Primary antibody deficiencies
35 Primary T-cell immunodeficiencies
36 Inherited disorders of IFN-γ-, IFN-α/β-, and NF-κB-mediated immunity
37 HIV infection and acquired immunodeficiency syndrome
38 Immunodeficiency due to congenital, metabolic, infectious,
surgical, and environmental factors



No. of pages:
© Saunders 2013
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"The authors and editors have taken pains to make the text clinician-friendly...The page layout is pleasing to the eye and easy to use." - JAMA, review of the last edition

"This is a 'must have' book for any serious student of clinical immunology...Certain highlights stand out for me: the use of line diagrams  to supplement histological photographs is excellent- to provide clarity to the features that are being demonstrated...overall , thiw book is very readable and user friendly, despite the size, and I learnt a lot. I heartily recommend this book."

British Journal of Immunology, December 2013