Clinical Immunology

Clinical Immunology

Principles and Practice

5th Edition - January 13, 2018

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  • Authors: Robert Rich, Thomas Fleisher, William Shearer, Harry Schroeder, Anthony Frew, Cornelia Weyand
  • Hardcover ISBN: 9780702068966
  • eBook ISBN: 9780702070396

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Keep abreast of the latest advances in this complex field with the 5th Edition of Clinical Immunology: Principles and Practice. This substantially revised edition by Drs. Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Harry W. Schroeder, Jr., Anthony J. Frew, and Cornelia M. Weyand, offers authoritative guidance from some of the most respected global leaders in immunology, helping you navigate today’s latest knowledge and evidence-based practices that result in improved patient care. This trusted resource features sweeping content updates, rewritten chapters, a highly clinical perspective, and an easy-to-use organization designed to enhance your diagnosis and management skills in daily practice.

Key Features

User-friendly format features color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles.

Table of Contents

  • Clinical Immunology



    Section 1 - Principles of Immune Response

    1. The Human Immune Response

    2. Organization of the Immune System

    3. Innate Immunity

    4. Antigen Receptor Genes, Gene Products, and Co-Receptors

    5. The Major Histocompatibility Complex

    6. Antigens and Antigen Presentation

    7. B-Cell Development and Differentiation

    8. T-Cell Development

    9. Cytokines and Cytokine Receptors

    10. Chemokines and Chemokine Receptors

    11. Lymphocyte Adhesion and Trafficking

    12. T-Cell Activation and Tolerance

    13. Regulated Cell Death

    14. The Microbiota in Immunity and Inflammation

    Section 2 - Host Defense Mechanisms and Inflammation

    15. Immunoglobulin Function

    16. Helper T-Cell Subsets and Control of the Inflammatory Response

    17. Cytotoxic T Lymphocytes and Natural Killer Cells

    18. Regulatory Immune Cells

    19. Host Defenses in the Skin

    20. Host Defenses at Mucosal Surfaces

    21. Complement in Host Deficiencies And Diseases

    22. Phagocyte Deficiencies

    23. Mast Cells, Basophils, and Mastocytosis

    24. Eosinophils and Eosinophilia

    Section 3 - Host Defenses to Infectious Agents

    25. Host Defenses to Viruses

    26. Host Defenses to Intracellular Bacteria

    27. Host Defenses to Extracellular Bacteria

    28. Host Defenses to Spirochetes

    29. Host Defenses to Fungi

    30. Host Defenses to Protozoa

    31. Host Defenses to Helminths

    Section 4 - Immunologic Deficiencies

    32. Approach to the Evaluation of the Immunodeficient Patient

    33. Human Genomics in Immunology

    34. Primary Antibody Deficiencies

    35. Primary T-cell Immunodeficiencies

    36. Immunodeficiencies at the Interface of Innate and Adaptive Immunity

    37. Infections in the Immunocompromised Host

    38. Immune Deficiencies at the Extremes of Age

    39. HIV Infection and Acquired Immunodeficiency Syndrome

    40. Autoantibody Mediated Phenocopies of Primary Immunodeficiency Diseases

    Section 5 - Allergic Diseases

    41. Immunological Mechanisms of Airway Diseases and Pathways to Therapy

    42. Urticaria, Angioedema, and Anaphylaxis

    43. Allergic Reactions to Stinging and Biting Insects

    44. Atopic and Contact Dermatitis

    45. Food Allergy

    46. Eosinophil-Associated Gastrointestinal Disorders

    47. Allergic Disorders of the Eye

    48. Drug Hypersensitivity

    49. Occupational Respiratory Allergies

    Section 6 - Systemic Immune Diseases

    50. Mechanisms of Autoimmunity

    51. Systemic Lupus Erythematosus

    52. Rheumatoid Arthritis

    53. Juvenile Idiopathic Arthritis

    54. Sjögren’s Syndrome

    55. Scleroderma-Systemic Sclerosis

    56. Inflammatory Muscle Diseases

    57. Spondyloarthritis

    58. Small and Medium Vessel Primary Vasculitis

    59. Large-Vessel Vasculitides

    60. Systemic Autoinflammatory Syndromes

    61. Antiphospholipid Syndrome

    Section 7 - Organ-Specific Inflammatory Disease

    62. Immunohematologic Disorders

    63. Bullous Diseases of the Skin and Mucous Membranes

    64. Immunology of Psoriasis

    65. Myasthenia Gravis

    66. Multiple Sclerosis

    67. Autoimmune Peripheral Neuropathies

    68. Immunologic Renal Diseases

    69. Inflammation and Atherothrombosis

    70. Autoimmune Thyroid Diseases

    71. Diabetes and Related Autoimmune Diseases

    72. Immunologic Lung Diseases

    73. Sarcoidosis

    74. Immunologic Ocular Disease

    75. Immunologic Diseases of the Gastrointestinal Tract

    76. Inflammatory Hepatobiliary Diseases

    Section 8 - Immunology of Neoplasia

    77. Tumor Immunotherapy

    78. Lymphoid Leukemias

    79. Lymphomas

    80. Monoclonal Gammopathies

    Section 9 - Transplantation

    81. Concepts and Challenges in Organ Transplantation: Rejection, Immunosuppression, and Tolerance

    82. Immune Reconstitution Therapy for Immunodeficiency

    83. Hematopoietic Stem Cell Transplantation for Malignant Diseases

    Section 10 - Prevention and Therapy of Immunologic Diseases

    84. Immunoglobulin Therapy: Replacement and Immunomodulation

    85. Gene Therapy

    86. Glucocorticoids

    87. Immunomodulating Pharmaceuticals

    88. Protein Kinase Antagonists as Therapeutic Agents for Immunological and Inflammatory Disorders

    89. Biological Modifiers of Inflammation

    90. Vaccines

    91. Immunotherapy of Allergic Disease

    Section 11 - Diagnostic Immunology

    92. Flow Cytometry

    93. Assessment of Functional Immune Responses

    94. Assessment of Neutrophil Function

    95. Assessment of Human Allergic Diseases

    96. Molecular Methods


    97. A1: Selected CD Molecules and their Characteristics

    98. A2: Laboratory Reference Values

    99. A3: Vaccine Schedules


Product details

  • No. of pages: 1392
  • Language: English
  • Copyright: © Elsevier 2018
  • Published: January 13, 2018
  • Imprint: Elsevier
  • Hardcover ISBN: 9780702068966
  • eBook ISBN: 9780702070396

About the Authors

Robert Rich

Affiliations and Expertise

Professor of Medicine and Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA

Thomas Fleisher

Affiliations and Expertise

Adjunct Professor of Pediatrics, USUHA, Chief, Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health, Bethesda MD, USA

William Shearer

Affiliations and Expertise

Professor of Pediatrics and of Pathology and Immunology, Baylor College of Medicine, Chief, Allergy and Immunology Service, Texas Children’s Hospital, Houston, TX, USA

Harry Schroeder

Affiliations and Expertise

Professor of Medicine, Microbiology, and Genetics

Anthony Frew

Affiliations and Expertise

Professor of Allergy and Respiratory Medicine, Department of Respiratory Medicine, Brighton General Hospital, Brighton, UK

Cornelia Weyand

Affiliations and Expertise

Professor of Medicine, Stanford University School of Medicine, Department of Medicine: Immunology and Rheumatology, Stanford, CA, USA

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