Clinical Immunobiology

Clinical Immunobiology

1st Edition - January 1, 1980

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  • Editors: Fritz H. Bach, Robert A. Good
  • eBook ISBN: 9781483216355

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Clinical Immunobiology, Volume 4 is a 13-chapter text that covers the advances in understanding of the concepts and practical applications of lymphoid subpopulations and the major histocompatibility complex (MHC). The first chapter presents an overview of the problems of various subpopulations of cells involved in the immune system. The succeeding chapters describe the techniques used for cell classification, either by their cell surface phenotype or by their responsiveness to a series of different stimuli. These chapters include surveys of the methods of detection of complement receptors and expression of these receptors on the surface of both normal and leukemic human lymphocytes. A discussion of the evidence that different T-lymphocyte populations differentially express receptor for IgG and IgM is also provided. Other chapters describe the relationship of MHC to serology of cell surface antigens and reactivity in the mixed leukocyte culture test. This work also explores the methods that employ the so-called "proliferative and cytotoxic responses". The remaining chapters look into the association between HLA antigens and a variety of different diseases. These chapters also discuss other genetic markers in the HLA linkage group. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

Table of Contents

  • List of Contributors


    Contents of Previous Volumes

    General Orientation of Human Lymphocyte Subpopulations

    I. Introduction

    II. Cytoplasmic Immunoglobulin

    III. Membrane Immunoglobulin

    IV. la System

    V. Epstein-Barr Virus (EBV) Receptor

    VI. Complement Receptors

    VII. Receptors for Fc Region of Immunoglobulins

    VIII. Enzymatic Markers

    IX. Receptors for Peanut Agglutinin

    X. Erythrocyte Receptors

    XI. Surface Antigens of Lymphocyte Subpopulations Defined by Monoclonal Antibodies

    XII. Relationship between Tγ Cells and Monocytes

    XIII. Distinction of Lymphocytes from Monocytes

    XIV. The Third-Cell Population or Unclassified Lymphoid Cells

    XV. Summary


    Lymphocyte Membrane Complement Receptors

    I. Introduction

    II. Methods for Detection of C Receptors

    III. Expression of C Receptors and Other Surface Markers on Normal and Leukemic Human Lymphocytes

    IV. Interpetation and Significance


    Regulatory Human T-Cell Subpopulations Defined by Receptors for IgG or IgM

    I. Introduction

    II. Enumeration and Isolation of T.M and T.G Cells

    III. Morphology of T.M and T.G Cells

    IV. Tissue Distribution of T.M and T.G Cells

    V. Functional Analysis of T.M and T.G Cells

    VI. Clinical Relevance of T.M and T.G Subpopulations

    Selected Reading



    I. Introduction

    II. Fundamentals of Lectin-Induced Mitogenesis

    III. Procedure for Determining in Vitro Lectin-Induced Activation of Lymphocytes

    IV. Clinical Usefulness of Lectins

    General Reading References

    Natural Killer Cells and Cells Mediating Antibody-Dependent Cytotoxicity Against Tumors

    I. Introduction

    II. Methods

    III. Characteristics of NK Cells and Their Relationship to K Cells

    IV. Specificity of Natural Cytotoxicity

    V. Factors Affecting Levels of NK and K Cell Activities

    VI. Possible Clinical Significance of These Effector Cells


    Regulation of the Immune System by Lymphocyte Sets: Analysis in Animal Models

    I. General Considerations

    II. Analysis in the Mouse

    III. Conclusions

    Selected References

    The Serology of HLA-A, -B, and -C

    I. Introduction

    II. Experimental Methods and Findings

    III. Conclusions


    The Serology of HLA-DR

    I. Introduction

    II. Technical Considerations

    III. Results

    IV. Discussion


    Cellular Immunogenetics—Definition of HLA-D Region Encoded Antigens by T Lymphocyte Reactivities

    I. Introduction

    II. Mixed Leukocyte Culture Homozygous Typing Cells

    III. Primed LD-Typing (PLT)

    IV. General Discussion


    Cell-Mediated Lympholysis

    I. Introduction

    II. Terminology

    III. Technique

    IV. Specificity of Cell-Mediated Lympholysis

    V. Genetic Control of CML

    VI. Cell-Mediated Lympholysis Typing

    VII. Preliminary Information from CML Typing Experiments

    VIII. Future Prospects

    Suggested Reading List

    HLA and Graft Survival

    I. Introduction

    II. Methodology

    III. Results

    IV. Discussion


    HLA and Disease

    I. Introduction

    II. Methods

    III. Relationships Between HLA and Diseases

    IV. Disease Heterogeneity

    V. Inheritance of Disease Susceptibility and Resistance

    VI. Mechanisms that Can Explain the Associations

    VII. Diagnostic and Prognostic Value

    Key References

    Other Markers in the HLA Linkage Group

    I. Introduction

    II. Genetic Considerations

    III. Other Markers in the HLA Linkage Group

    IV. Complement Components

    V. Intracellular Enzymes

    VI. Concluding Remarks

    Selected References


Product details

  • No. of pages: 222
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 1, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9781483216355

About the Editors

Fritz H. Bach

Robert A. Good

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