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Clinical Immunobiology - 1st Edition - ISBN: 9780120700035, 9781483216348

Clinical Immunobiology, Volume 3

1st Edition

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Editors: Fritz H. Bach Robert A. Good
eBook ISBN: 9781483216348
Imprint: Academic Press
Published Date: 1st January 1976
Page Count: 462
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Table of Contents

List of Contributors


Contents of Previous Volumes

Evaluation of the Immunoglobulins

I. Introduction

II. Techniques

III. Results

IV. Summary


Electrophoresis and Immunoelectrophoresis in the Evaluation of Homogeneous Immunoglobulin Components

I. Introduction

II. Homogeneous Proteins in Disease States

III. Techniques for Characterization and Quantitation of Homogeneous Immunoglobulin Components

IV. Evaluation of Test Results

V. Conclusions


Serum Concentrations of IgG Subclasses

I. Introduction

II. Quantitative Determination of IgG Subclasses

III. IgG Subclass Concentrations in Sera of Normal Individuals

IV. Subclass Levels in Sera of Patients with Increased Concentrations of Total IgG

V. IgG Subclasses in Primary Immunodeficiency Diseases

VI. IgG Subclasses after Bone Marrow Transplantation in Severe Combined Immunodeficiency


Imbalances of the κ/λ Ratio of Human Immunoglobulins

I. Introduction

II. Methods for Detection of Human Immunoglobulin Light-Chain Imbalances

III. Analyses of Normal and Pathological Sera

IV. Conclusions


Metabolism of Immunoglobulins

I. Introduction

II. Methods Used in Immunoglobulin Turnover Studies

III. Metabolism of Immunoglobulins in Normal Individuals

IV. Problems in Interpretation of the Data

V. Disorders of Immunoglobulin Metabolism

VI. Summary


Cell-Mediated Immunity: In Vivo Testing

I. Introduction

II. Skin Test Battery

III. Results

IV. Differential Diagnosis


Cellular Immunity: Antibody-Dependent Cytotoxicity (K-Cell Activity)

I. Introduction

II. Model Studies with Effector Cells from Nonimmune Donors

III. K-Cell Activity in Different Immune Systems


Short-Term 51Cr-Release Tests for Direct Cell-Mediated Cytotoxicity: Methods, Clinical Uses, and Interpretations

I. Introduction

II. Pathways for Direct Cell-Mediated Cytotoxicity

III. Methodology

IV. Examples of Clinical Applications

V. Interpretive Limitations

VI. Some Future Applications

VII. Concluding Comments


Lymphocyte Transformation in Vitro in Response to Mitogens and Antigens

I. Introduction

II. Lymphocyte Activation: Specific or Nonspecific

III. Characteristics of the Reaction

IV. Regulation of the Reaction

V. Lymphocyte Transformation in Vitro in Clinical Immunology


Products of Activated Lymphocytes

I. Introduction

II. Cell Migration Inhibition System

III. Macrophage Activation by Lymphocyte Mediators

IV. Macrophage (Monocyte) Chemotactic Factor

V. Lymphocyte Mitogenic (Blastogenic ) Factors

VI. Cytotoxic Factors ( Lymphotoxins )

VII. Interferon

VIII. Summary


Leukocyte Aggregation Test for Evaluating Cell-Mediated Immunity

I. Introduction

II. Method

III. Results

IV. Discussion


The HLA System: Serologically Defined Antigens

I. The HLA System: Serologically Defined Antigens

II. HLA and Transplantation

III. HLA and Disease

IV. Clinical Application


Mixed Leukocyte Cultures: A Cellular Approach to Histocompatibility Testing

I. Introduction

II. Methods

III. Results

IV. Clinical Usefulness of Mixed Leukocyte Culture Testing

V. Addendum


The Reticuloendothelial System

I. Introduction

II. Clearance Testing

III. Rebuck Skin Windows

IV. Cellular Studies


Assessment of Allergic States: IgE Methodology and the Measurement of Allergen-Specific IgG Antibody

I. Introduction

II. Total Serum IgE

III. Allergen-Specific IgE

IV. Allergen-Specific IgG Antibodies

V. Conclusions

Selected References

Autoantibodies in Hematological Disorders

I. Introduction

II. Autoimmune Hemolytic Anemia

III. Autoantibodies against Thrombocytes

IV. Autoantibodies against Leukocytes



Rheumatoid Factors in Human Disease

I. Introduction

II. General Test Procedures

III. Clinical Significance

Appendix: Commonly Used Rheumatoid Factor Tests


Antibodies to Nucleic Acids

I. Introduction

II. Performance of the Tests

III. Results and Interpretation

IV. Differential Diagnosis



I. Introduction

II. Complement Components and Activation Sequence

III. Biological Activities of Complement

IV. Test Involving Complement

V. Complement-Fixation Tests

VI. Miscellaneous Tests

VII. Complement Abnormalities in Disease

VIII. Inherited Disorders of the Complement System


Detection of Tumor-Associated Antigens in Plasma or Serum

I. Introduction

II. α-Fetoprotein

III. Carcinoembryonic Antigen

IV. Other Antigens, Antibodies

V. Conclusion


Neutrophil Function

I. Introduction

II. Phagocytosis

III. Bactericidal Assays of Neutrophils

IV. Assays of Neutrophil Movement


Subject Index


Clinical Immunobiology, Volume 3 covers a variety of methods used for assaying the immune status of an individual.

This volume is composed of 21 chapters and begins with a presentation of the background and issues to which clinical tests would be applied. The succeeding chapters outline the methodological procedures used in the analyses. Other chapters present some examples of the kinds of data that can be generated with the procedures used and provide guidelines for interpretation of the tests. The remaining chapters discuss the value of the immunological test procedures in differential diagnosis and analysis of diseases. These chapters also explore the usefulness of these procedures in prognosis of disease and the consequences of immunological manipulation undertaken for treatment or prevention of disease.

This book will be of great value to clinical immunobiologists, biochemists, and researchers.


No. of pages:
© Academic Press 1976
1st January 1976
Academic Press
eBook ISBN:

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About the Editors

Fritz H. Bach

Robert A. Good