Clinical Immunobiology

Clinical Immunobiology

1st Edition - January 1, 1972

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  • Editors: Fritz H. Bach, Robert A. Good
  • eBook ISBN: 9781483216324

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Clinical Immunobiology, Volume 1 is a 12-chapter introductory text to the several aspects of immunobiology field. The opening chapters describe the structural and functional development, as well as the molecular and cellular nature of the immune apparatus. The subsequent chapters deal with the relation of structure to function in the lymphoid system and its molecules. These topics are followed by discussions of the fundamental issues of tolerance, inflammation, immunological mediators and amplifiers, and immunogenetics. The remaining chapters explore the immunobiological aspects of transplantation, allergy, tumor immunity, autoimmunity, immunodeficiency, and immunosuppression. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

Table of Contents

  • List of Contributors


    Structure-Function Relations in the Lymphoid System

    I. Introduction

    II. The Two-Component Concept

    III. Development of B and T Cells

    IV. Major Function of T Cells

    V. Location and Nature of T Cells

    VI. Distribution of T Cells

    VII. The Nature and Distribution of B Cells

    VIII. Development and Structure of the Thymus

    IX. Functions of the Thymus

    X. T-Cell Markers

    XI. B-Cell Markers

    XII. Structure and Function of the Bursa

    XIII. The Bursal Equivalent

    XIV. T-Cell-B-Cell Interactions

    XV. Involution of the Immunological Systems

    XVI. Immunodeficiency Diseases of Man in Light of the Differentiation of T and B Cells

    XVII. The Crucial Experiments of Nature


    The Immunoglobulins

    I. Introduction

    II. Methods of Study

    III. Problems of Heterogeneity

    IV. Nomenclature

    V. Antigenic Markers

    VI. Gross Structural Relations

    VII. Metabolism and Distribution of the Immunoglobulins

    VIII. Function of Immunoglobulins and Structure-Function Relationships

    IX. Cell Surface Immunoglobulins and Receptors

    X. Phylogeny and Ontogeny

    XI. Conclusion

    Cellular Immunity

    I. Introduction

    II. Some Definitions and the Ingredients of the Reaction

    III. Cellular Immunity—A Basis for Immunological Homeostasis

    IV. Immunological Surveillance and Tumor Espionage

    V. Microbial Parasitism and Self + χ Linkage—An Invitation to Autoimmunity

    VI. Mechanisms of Cellular Immunity—in Vivo Expressions

    VII. In Vitro Correlates of Cellular Immunity and Their Mediators

    VIII. In Vivo Realities—The Scope of Cellular Immunity

    IX. Immunological Amnesia—The Price of Immunosuppression

    X. Deciphering the Language of Cells

    XI. Cellular Ecology—Waste Disposal and the Loss of Immunological Virginity

    XII. Cries of Relevance and Immunological Reconstitution

    XIII. Conclusion


    Transplantation Immunology

    I. Introduction

    II. Mechanisms of Rejection

    III. Physiological Consequences of Classic Rejection

    IV. Immunosuppression

    V. Changing Host-Graft Relationships

    VI. Graft Pretreatment

    VII. Histocompatibility Typing in Patients

    VIII. Is Clinical Organ Transplantation Practical?


    Immunological Tolerance

    I. Introduction

    II. Relevance to Medicine

    III. T and B Lymphocytes

    IV. Antibody Affinity

    V. Protein Antigens

    VI. Pneumococcal Polysaccharide

    VII. Antigen-Binding Cells in Tolerant Animals

    VIII. In Vitro Tests for Cell-Mediated Cytotoxicity

    IX. Blocking and Unblocking Serum Factors

    X. Induced Tolerance to Allogeneic Cells

    XI. Chimerism

    XII. Transplanted Organs

    XIII. Viruses and Virus-Induced Tumors

    XIV. Tolerance to Foreign Red Blood Cells

    XV. Tolerance to Skin Sensitizers

    XVI. T-Cell Control

    XVII. Ontogeny of Immune Responsiveness

    XVIII. Development of Autoimmunity

    XIX. In Vitro Studies of Tolerance and Underlying Mechanisms



    I. Introduction

    II. Vascular Phase

    III. Cellular Phase

    IV. Lymphatics

    V. Mediators

    VI. Control of Inflammation

    VII. Chronic Inflammation

    VIII. Conclusion


    Fundamental Immunogenetics—Their Application to Histocompatibility

    I. Introduction

    II. Basic Genetics

    III. Genes and Antigens

    IV. Transplantation Genetics in the Mouse

    V. Histocompatibility in Man

    VI. Addendum

    Humoral Amplification Systems in Inflammation

    I. Introduction

    II. Complement

    III. Kinin-Generating System

    IV. Concluding Comments




    I. Agents or Methods That Do Not Discriminate for Lymphocytes

    II. Agents That Discriminate for Lymphocytes

    III. Agents That Discriminate for Macrophages

    IV. Agents That Discriminate between Lymphocyte Subpopulations

    V. Agents That Discriminate for Specific Reactive Lymphocyte Clones

    Miscellaneous Comments


    Tumor Immunology

    I. Introduction

    II. Critical Demonstration of Specific Defense Reactions against Experimental Tumors

    III. Tumor-Associated Antigens in Virus-Induced Experimental Neoplasms

    IV. In Vitro Approaches

    V. Escapes

    VI. Studies on Human Tumors

    VII. Etiological Clues



    I. Introduction

    II. The Target Cells

    III. The Antibodies

    IV. The Allergens

    V. Mediators

    VI. The Interaction between Cell-Bound IgE and Allergen

    VII. Mechanism of Mediator Release by the IgE-Allergen Interaction

    VIII. The Relation of Intrinsic Asthma to the Allergic Response

    IX. The Clinical Diagnosis of Allergic Diseases

    X. The Pharmacological Therapy of Allergic Diseases

    XI. The Immunological Therapy of Allergic Diseases


    Immunological Deficiency Disease

    I. Introduction

    II. Severe Combined Immunodeficiency

    III. Infantile X-Linked Agammaglobulinemia

    IV. Transient Hypogammaglobulinemia of Infancy

    V. Selective Immunoglobulin Deficiencies

    VI. X-Linked Immunodeficiency wity Hyper-IgM

    VII. Congenital Thymic Aplasia (DiGeorge’s Syndrome)

    VIII. Episodic Lymphopenia with Lymphocytotoxin

    IX. Wiskott-Aldrich Syndrome

    X. Hereditary Ataxia-Telangiectasia

    XI. Immunodeficiency with Normal or Hyperimmunoglobulinemia

    XII. Immunodeficiency with Short-Limbed Dwarfism

    XIII. Immunodeficiency with Thymona

    XIV. Common, Variable, Unclassifiable Immunodeficiency

    XV. Secondary Defects in Immunity

    XVI. Summary


    Subject Index

Product details

  • No. of pages: 310
  • Language: English
  • Copyright: © Academic Press 1972
  • Published: January 1, 1972
  • Imprint: Academic Press
  • eBook ISBN: 9781483216324

About the Editors

Fritz H. Bach

Robert A. Good

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