The Human Genome Project has triggered a technological revolution influencing nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy. Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies presents and analyzes ethical issues raised by the latest genetic and genomic technologies of relevance to these fields, and provides practical recommendations, guidelines, and algorithms to support ethically sound approaches to prenatal genetic testing, gene therapy, genetic counseling and other aspects of clinical practice.
Broken into two parts, preconception and post-conception bioethical issues, Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers thorough discussion of preconception carrier screening, genetic engineering and use of CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction and the moral status of the embryo, genetic enhancement, and sharing genetic data among other topics. Chapter contributions from leading bioethicists and clinicians encourage a global, holistic perspective on applied challenges and moral questions related to implementing genetic reproductive technology, enhancing the book’s practical value for practitioners, regulators, lawmakers, clinical researchers, genetic counselors, and graduate and medical students.
- Provides practical analysis of ethical issues raised by cutting-edge techniques and recent advances in prenatal and reproductive genetics
- Chapter contributions from leading bioethicists and clinicians offer a global, holistic perspective on applied challenges and moral questions related to implementing genetic and genomic reproductive technology, enhancing the book’s practical value for clinical practitioners, regulators, lawmakers, clinical researchers, and graduate and medical students, and encouraging ethically sound approaches to prenatal genetic testing, gene therapy, and genetic counseling
- Thoroughly discusses preconception carrier screening, genetic engineering and use of CRISPR gene editing, mitochondrial gene replacement therapy, ethical issues raised by multi-parents and same sex parents, sex selection, predictive testing, embryo reduction and the moral status of the embryo, secondary findings in prenatal testing, genetic enhancement, and sharing genetic data among other topics
- Focuses heavily on ethical issues related to the latest developments in reproductive genetics, including new prenatal testing methods and gene editing approaches
Active researchers, basic and translational scientists, clinicians, and students in the areas of human genetics, medical genetics, genomics, reproductive medicine, gynecology, obstetrics, andrology, embryology, prenatal testing, and genetic testing; genetic counselors; bioethicists; fertility specialists; lawmakers and regulators; medical students and residents; pharmacologists
Part 1. The right versus moral duty to have a perfect genetic child
1. Predictive testing for neurodegenerative diseases
2. Predictive testing for common, multifactorial diseases
3. Whole genome sequencing as a method of prenatal genetic diagnosis
4. Prenatal testing for autosomal recessive disorders
5. Using crispr/cas 9 to select a perfect child
6. Prenatal testing without an objective medical reason
7. Expanded preconception carrier screening
8. Using genetic modifications for enhancement
9. Ethics of mitochondrial gene replacement therapy
Part 2. New issues arising within the geneticist - patient relationship
10. Revisiting the non-directive principle of genetic testing
11. Should incidental findings arising from prenatal tested be reported indiscriminately to patients?
Part 3. New issues generated by atypical family cores
12 Ethical issues raised by multi-parents
13. Ethical issues raised by same gender parents
- No. of pages:
- © Academic Press 2018
- 1st August 2018
- Academic Press
- Paperback ISBN:
Sorin Hostiuc, MD, PhD, is an Assistant Professor in the Department of Legal Medicine and Bioethics at Carol Davila Medicine and Pharmacy University, Bucharest, Romania, and Senior Physician at the National Institute of Legal Medicine Bucharest, Romania. Dr. Hostiuc has written extensively on such topics as informed consent, research ethics, history of medical ethics, and reproductive ethics, with over 100 published articles in PLOS ONE, Journal of Translational Medicine, and Frontiers in Neuroscience among other journals. He has also published three monographs in the Romanian language dealing with bioethical issues, including Ethics of Scientific Research, Ethics of Scientific Publishing, and Informed Consent, as well as a book chapter on the current state of bioethics in Bioethics – A Global Discourse (LIT Verlag Publishers, 2016). Dr. Hostiuc received his PhD in medicine and his MD, from Carol Davila Medicine and Pharmacy University. He also completed a certification in research ethics at the Icahn School of Medicine at Mount Sinai, New York, USA.
Assistant Professor, Department of Legal Medicine and Bioethics, Carol Davila Medicine and Pharmacy University, Bucharest, Romania, and Senior Physician, National Institute of Legal Medicine Bucharest, Romania