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Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Topics discussed include the omics landscape of impaired mitochondrial bioenergetics, hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therapeutic opportunities for impaired bioenergetics, addressing both known treatment pathways and future directions for research, are discussed in-depth.
Diseases and Disorders examined include brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among others.
- Provides a thorough discussion of foundational aspects of bioenergetics and disease, modes of analysis, and treatments for impaired bioenergetics
- Discusses the role of bioenergetics and treatment pathways in brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among other diseases and disorders
- Features chapter contributions from international leaders in translational bioenergetics research and clinical practice
Active researchers in biochemistry, molecular biology, cell biology, oncology, pharmacology; clinician scientists
Part I: Foundational aspects of bioenergetics and disease
1. Tissue specificity of energy metabolism in mitochondria
2. Impaired mitochondrial bioenergetics and signaling pathways: an overview
Part II: Disease-specific case studies
3. Abnormal mitochondrial metabolism in obesity and insulin resistance
4. Impaired mitochondrial energy metabolism: etiologies and implications in neurodegenerative disease
5. Mitochondrial dysfunction in kidney diseases
6. Mitochondrial role in NAFLD as a chronic disease
7. Decreased bioenergetics in traumatic brain injury
8. Impaired mitochondrial bioenergetics in psychiatric disorders
Part III: Modes of analysis in clinical bioenergetics
9. Monitoring mitochondrial oxygenation in clinical environment
10. Assessing metabolic flexibility and mitochondrial bioenergetics
11. Assessing the real-time metabolism and bioenergetics of single cells using fluorescence biosensors
12. Bioenergetic profiling in the skin
13. Evaluating tissue bioenergetics by phosphorous-31 magnetic resonance spectroscopy
14. Targeting respiratory complex Idmolecular mechanism and drug design
Part IV: Theraputic opportunities for impaired bioenergetics
15. Targeting Alzheimer’s disease neuronal mitochondria as a therapeutic approach
16. Mitochondria replacement as an innovative treatment to tackle impaired bioenergetics in clinical medicine
17. Mitochondrial drug delivery systems: therapeutic application for clinical bioenergetics in neurodegenerative disease
18. Dietary interventions for patients with obesity and impaired bioenergetics
19. Novel nutraceuticals to tackle brain and muscle bioenergetics
20. Therapeutic targeting of cardiolipin composition in injury and disease using TPP-conjugated compounds
21. NEET proteins as novel drug targets for mitochondrial dysfunction
22. Translation of bioenergetics therapies: challenges from bench to bedside
23. New therapeutics to modulate mitochondrial energy metabolism in neurodegenerative disorders: the example of mitochondrial disorders
24. Targeting impaired bioenergetics in heart failure
25. Exploring vulnerabilities of quiescent tumor cells by targeting mitochondrial bioenergetics
26. Modulation of the mitochondrial function with polyphenols and other natural bioactive compounds to treat obesity
27. Antioxidants and natural-derived products in the modulation of mitochondrial bioenergetics and dysfunction in chronic kidney disease models
28. Transcranial and systemic photobiomodulation for the enhancement of mitochondrial metabolism in depression
29. Alterations in mitochondrial glucose carbon metabolism in epilepsy and targeted metabolic treatments
- No. of pages:
- © Academic Press 2021
- 13th November 2020
- Academic Press
- Paperback ISBN:
- eBook ISBN:
Dr. Sergej M. Ostojic is a Full Professor in the Biomedical Sciences Department of the University of Novi Sad, Belgrade, Serbia. His current research is focused on evaluating effectiveness and safety of novel mitochondria-targeted nutraceuticals (including molecular hydrogen, creatine salts and guanidinoacetic acid) tackling impaired bioenergetics in health and disease. To date, he has authored and co-authored over 160 peer-reviewed research and review articles in high-impact journals, such as The Lancet, Trends in Endocrinology and Metabolism, Theranostics, Sports Medicine, Mayo Clinic Proceedings, Clinical Science, Pharmacological Research, International Journal of Cardiology, and the European Journal of Nutrition. He is a member of the American Society for Nutrition, the American Physiological Society, the American College of Sports Medicine, and the Nutrition Society, and has been the recipient of internationally research grants such as the World Anti-Doping Agency and NSCA International Award. Dr. Ostojic holds 4 patents in the US, UK, EU, and Japan.
Full Professor, University of Novi Sad, Biomedical Sciences Department, Belgrade, Serbia
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