Clinical Biochemistry V2

Clinical Biochemistry V2

Contemporary Theories and Techniques

1st Edition - January 28, 1982

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  • Editor: Herbert Spiegel
  • eBook ISBN: 9780323155526

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Description

Clinical Biochemistry: Contemporary Theories and Techniques, Volume 2 is a collection of papers that deals with coagulation chemistry, inborn errors of metabolism (IEM), and the biochemistry of aging. One paper explains the biochemistry and clinical importance of lipoprotein-X (LP-X) as a marker for obstructive jaundice and also as a pointer in the deficiency of lecithin-cholesterol acyltransferase (LCAT), a rare inborn error of metabolism. Another paper presents guidelines in determining radioimmunoassay that are used, for example, in identifying enzymes produced by various malignant lesions. One paper reviews the basic molecular events and interactions involved in the blood clotting process and its related systems. To determine inborn errors of metabolism, the investigator can use screening techniques, prenatal diagnosis or therapy, and laboratory procedures related to IEM. To correct errors at the gene level, transgenosis and genetic engineering use recombinant DNA research techniques involving the introduction of a foreign DNA into the host cell. Some examples of IEM are phenylketonuria and hyperphenylalaninemia without PKU. This collection can prove useful for the clinical chemists, endocrinologists, internists, medical practitioners, and investigators involved in research on biochemistry.

Table of Contents


  • Contributors

    Preface

    Acknowledgments

    Contents of Volume 1

    1 Biochemistry and Clinical Significance of Lipoprotein-X

    I. Introduction

    II. Chemistry of LP-X

    III. Analysis of LP-X Preparations

    IV. Properties of LP-X

    V. Methodology for the Measurement of LP-X

    VI. LP-X and LCAT Activity

    VII. Clinical Usefulness

    VIII. Metabolism

    IX. Conclusion

    References

    2 Radioimmunoassay

    I. Introduction

    II. Immunological Background in Radioimmunoassay

    III. Preparation of Antibodies

    IV. Labeling of Antigen

    V. Principle of Gamma- and Beta-Scanning Equipment

    VI. Rationale of Radioimmunoassay

    VII. Methods of Separating Bound from Free Antigen

    VIII. Calculation and Evaluation

    IX. RIA of Polypeptide-Releasing Factors

    X. Polypeptide Hormones from the Neurophypophysis

    XI. Polypeptide Hormones from the Adenophypophysis

    XII. Gastrointestinal Polypeptide Hormones

    XIII. Calcitrophic Polypeptides

    XIV. Placental Polypeptides

    XV. Steroid Hormones

    XVI. Cancer Markers

    XVII. Various Proteins

    XVIII. Miscellaneous

    XIX. New Concepts in RIA

    XX. Monoclonal Antibodies

    XXI. Conclusion

    References

    3 Thyroid Function

    I. Introduction

    II. Thyroid Physiology

    III. Laboratory Approach to Thyroid Disease

    IV. Special Concerns for the Clinical Chemist

    References

    4 Coagulation Chemistry

    I. Introduction

    II. Hemostasis

    III. Overview of the Mechanism of Blood Coagulation

    IV. Biochemistry of the Intrinsic Blood Coagulation System

    V. Biochemistry of the Extrinsic Blood Coagulation System

    VI. The Common Pathway of Blood Coagulation

    VII. Biochemistry of the Transformation of Fibrinogen to Fibrin

    VIII. Significance of Coagulation Biochemistry

    References

    5 Inborn Errors of Metabolism

    I. Introduction and Historical Background

    II. Mendelian Inheritance: Modes of Genetic Transmission

    III. Gene Mapping

    IV. Biochemical Genetics

    V. Consequences of Inborn Errors of Metabolism

    VI. Experimental Approaches and Methods of Diagnosis for Inborn Errors of Metabolism

    VII. Genetic Screening

    VIII. Prenatal Diagnosis of Inherited Metabolic Disorders

    IX. Therapy of Inborn Errors of Metabolism

    X. Biochemical and Genetic Heterogeneity

    XI. Classification of Inborn Errors of Metabolism

    XII. Examples of Inborn Errors of Metabolism

    References

    6 Biochemistry of Aging

    I. The Evolution of Aging

    II. Primary and Secondary Causes of Aging

    III. The Chain of Life and the First Law of LeCompte

    IV. The Vulnerability of Molecules in Transit

    V. Approaches to Measurement of Physiological Age

    VI. The Exogenous Factors

    VII. The Endogenous Factors

    VIII. Direct Causes of Premature Decline and Death

    IX. Approaches to the Extension of a Healthy Life

    X. The Central Facts

    References

    7 Quantitation and Interpretation of Serum Drug Concentrations

    I. Introduction

    II. Clinical Pharmacology-An Overview

    III. Pharmacokinetics

    IV. Individualization of Dosage

    V. Basic Guidelines for Routine Therapeutic Drug Monitoring

    VI. Optimal Therapy Requirement of a Minimum Effective Concentration

    VII. Pediatric Clinical Pharmacology

    VIII. Guide to Therapeutic Drug Monitoring

    IX. An Overview of the Role of the Clinical Laboratory in Therapeutic Drug Monitoring

    References

    Index

Product details

  • No. of pages: 334
  • Language: English
  • Copyright: © Academic Press 1982
  • Published: January 28, 1982
  • Imprint: Academic Press
  • eBook ISBN: 9780323155526

About the Editor

Herbert Spiegel

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