Clinical Biochemistry of Domestic Animals

Clinical Biochemistry of Domestic Animals

3rd Edition - January 1, 1980

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  • Editor: Jiro J. Kaneko
  • eBook ISBN: 9781483273655

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Clinical Biochemistry of Domestic Animals, Third Edition, represents a major revision of the previous editions. Since the publication of the first edition of ""Clinical Biochemistry of Domestic Animals,"" veterinary clinical biochemistry has enjoyed a virtual explosion of new knowledge commensurate with the increased importance of companion animals, the livestock industry, and experimental animals. This third edition brings together some of the most important areas of clinical biochemistry pertinent to these sectors. For this purpose, new chapters on the reproductive hormones and clinical enzymology have been added, in addition to a rewriting of the chapters on renal function and plasma proteins and extensive revisions of all other chapters. The volume contains 18 chapters and opens with discussions of carbohydrate and lipid metabolism and associated disorders. This is followed by separate chapters on serum proteins and the dysproteinemias; porpyhrins; clinical enzymology; liver, pancreatic, and kidney function; and the physiology and pathophysiology of body fluids. Subsequent chapters deal with pituitary, adrenal, and thyroid function; skeletal muscle function; calcium, phosphorus, magnesium, and iron metabolism; the mechanisms of homeostasis; and cerebrospinal fluid physiology.

Table of Contents

  • List of Contributors


    1 Carbohydrate Metabolism and Its Disorders

    I. Introduction

    II. Digestion

    III. Absorption

    IV. Metabolism of Absorbed Carbohydrates

    V. Interrelationships of Carbohydrate, Lipid, and Protein Metabolism

    VI. Insulin and Carbohydrate Metabolism

    VII. Blood Glucose Concentration and It's Regulation

    VIII. Methodology

    IX. Disorders of Carbohydrate Metabolism

    X. Disorders of Ruminants Associated with Hypoglycemia


    2 Lipid Metabolism and Its Disorders

    I. Introduction

    II. Classes of Lipids

    III. Chemistry of Some Lipids

    IV. Digestion and Absorption of Lipids

    V. Fate of Dietary Lipids

    VI. Transport of Lipids

    VII. Biosynthesis of Lipids

    VIII. Oxidation of Fatty Acids

    IX. Special Aspects of Lipid Metabolism in Domestic Animals


    3 Serum Proteins and the Dysproteinemias

    I. Introduction

    II. Methodology

    III. Normal Serum Proteins

    IV. Interpretation of Serum Protein Profiles


    4 Porphyrins, Heme, and Erythrocyte Metabolism: The Porphyrias

    I. Introduction

    II. Erythropoiesis

    III. The Developing Erythrocyte and Reticulocyte

    IV. The Mature Erythrocyte

    V. Determinants of RBC Survival

    VI. Porphyrias of Animals


    5 Clinical Enzymology

    I. Introduction

    II. Basic Enzymology

    III. Serum Enzymes of Clinical Diagnostic Importance

    IV. Organs


    6 Liver Function

    I. Introduction

    II. General Types of Liver Disease

    III. Indication for Liver Function Tests

    IV. Classification of Liver Function Tests

    V. Tests Measuring the Hepatic Transport (Uptake, Conjugation, and Excretion) of Organic Anions

    VI. Serum Enzyme Tests

    VII. Specific Biochemical Tests

    VIII. Liver Biopsy and Radiographic Procedures


    7 Pancreatic Function

    I. Introduction

    II. Psychology of the Pancreas

    III. Pancreatic Disease

    IV. Laboratory Diagnostic Aids


    8 Gastrointestinal Function

    I. Introduction

    II. Gastrointestinal Secretion

    III. Digestion and Absorption

    IV. Disturbances of Gastrointestinal Function


    9 Kidney Function

    I. Introduction

    II. Normal Renal Functions

    III. Alterations in Renal Function Due to Extrarenal Factors

    IV. Primary Renal Dysfunction—Acute Failure

    V. Primary Renal Dysfunction—Chronic Failure

    VI. Urinalysis

    VII. Tests of Renal Function


    10 Fluids, Electrolytes, and Acid-Base Balance

    I. Introduction

    II. Physiology of Body Fluids

    III. Pathophysiology of Body Water

    IV. Pathophysiology of Osmotic Pressure

    V. Salt and Water Interrelationships

    VI. Pathophysiology of Acid-Base Balance

    VII. Pathophysiology of Potassium Metabolism

    VIII. Role of Anions

    IX. Clinical Evaluation of Patients

    X. Laboratory Evaluation of Patients

    XI. Clinical Syndromes Associated with Disturbances of Water, Electrolyte, and Acid-Base Balance

    XII. Fluid Therapy


    11 Pituitary and Adrenal Function

    I. Introduction

    II. Hormones of the Adenohypophysis

    III. Hormones of the Neurohypophysis

    IV. Hormones of the Adrenal Cortex

    V. Hormones of the Adrenal Medulla

    VI. Tests of Function


    12 Thyroid Function

    I. Introduction

    II. Anatomical Considerations

    III. Physiology

    IV. Thyroid Function Tests

    V. Disorders of Iodine Metabolism


    13 Reproductive Hormones

    I. Introduction

    II. Assay Methods

    III. Physiology of Reproductive Hormones in the Female

    IV. Clinical Aspects of Reproductive Endocrinology


    14 Skeletal Muscle Function

    I. Introduction

    II. Sarcoplasmic Organelles and Muscular Contraction

    III. Heterogeneity of Skeletal Muscle

    IV. Neural Tropic Influences on Muscle

    V. Adaptations to Exercise

    VI. Serum Enzyme Determinations in the Diagnosis of Neuromuscular Disorders

    VII. Muscle Biopsy and Histochemistry in the Diagnosis of Neuromuscular Disorders


    15 Calcium, Phosphorus, and Magnesium Metabolism

    I. Calcium and Inorganic Phosphorus Metabolism

    II. Serum Calcium and Phosphorus Levels

    III. Abnormal Calcium and Phosphorus Metabolism

    IV. Bone Disorders

    V. Magnesium Metabolism

    VI. Serum Magnesium

    VII. Disturbances of Magnesium Metabolism


    16 Iron Metabolism

    I. Introduction

    II. Iron Balance

    III. Dietary Iron

    IV. Iron Metabolism

    V. Tests of Iron Metabolism

    VI. Disorders of Iron Metabolism


    17 Hemostasis and Coagulation

    I. Introduction

    II. Mechanisms of Hemostasis

    III. Laboratory Diagnosis of Bleeding Disorders

    IV. Bleeding Disorders


    18 Cerebrospinal Fluid

    I. Introduction

    II. Secretion of CSF

    III. Outflow of CSF

    IV. Factors Governing CSF Composition

    V. Blood-Brain Barrier

    VI. Composition of CSF

    VII. Removal of CSF

    VIII. Examination of CSF

    IX. CSF in Disease


    19 Synovial Fluid

    I. Introduction

    II. Characteristics and Composition of Synovial Fluid

    III. Examination of Synovial Fluid

    IV. Pathological Changes in Synovial Fluid



    Appendix I. SI Units

    Appendix II. Conversion Factors of Some Conventional Serum Enzyme Units to International Units

    Appendix III. Temperature Correction Factors for Some Common Enzymes

    Appendix IV. Stability of Enzymes in Serum under Various Storage Conditions

    Appendix V. Temperature Conversions from Degrees Fahrenheit to Degrees Celsius

    Appendix VI. Normal Concentrations of Blood Constituents in Domestic Animals

    Appendix VII. Normal Concentrations of Urine Constituents in Domestic Animals

    Appendix VIII. Normal Concentrations of Constituents of Cerebrospinal Fluid in Domestic Animals


Product details

  • No. of pages: 846
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 1, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9781483273655

About the Editor

Jiro J. Kaneko

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