Clinical and Experimental Toxicology of Organophosphates and Carbamates

Clinical and Experimental Toxicology of Organophosphates and Carbamates

1st Edition - March 24, 1992

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  • Authors: Bryan Ballantyne, Timothy C. Marrs
  • eBook ISBN: 9781483193656

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Clinical & Experimental Toxicology of Organophosphates and Carbamates considers the histochemical localization of cholinesterase in anticholinesterase poisoning. This book is organized into eight parts encompassing 59 chapters that discuss the pharmacology and toxicology of carbamates, as well as the neurobehavioral toxicology of anticholinesterases. Some of the topics covered in the book are the overview of biological and clinical aspects of organophosphates and carbamates; biochemical determination of cholinesterase activity in fluids and tissues; intermediate syndrome in anticholinesterase neurotoxicity; structure-activity relationships and anticholinesterase activity; and the molecular events in delayed neuropathy. Other parts deal with the cardiac effects of anticholinesterase agents and the ecotoxicological consequences of interactions between avian esterases and organophosphorus compounds. These topics are followed by discussions on the analysis of the cutaneous and respiratory tract absorption of anticholinesterases and the use of organophosphorus compounds as chemical warfare agents. The final parts are devoted to the toxicity of anticholinesterases to aquatic organisms. The book can provide useful information to toxicologists, doctors, students, and researchers.

Table of Contents

  • Foreword


    List of Contributors

    Abbreviations Used in the Text

    Part 1 Basic Science

    1 Overview of the Biological and Clinical Aspects of Organophosphates and Carbamates

    2 Biochemical Determination of Cholinesterase Activity in Biological Fluids and Tissues

    3 Histochemical Localization of Cholinesterase in Anticholinesterase Poisoning

    4 Pharmacology and Toxicology of Organophosphates

    5 Pharmacology and Toxicology of Carbamates

    6 Structure-Activity Relationships and Anticholinesterase Activity

    Part 2 Neurotoxicity

    7 Neurobehavioural Toxicology of Anticholinesterases

    8 Central Neurotoxicity and Behavioural Effects of Anticholinesterases

    9 Acute and Subchronic Neurotoxicity and Cardiotoxicity of Anticholinesterases

    10 Molecular Events in Delayed Neuropathy: Experimental Aspects of Neuropathy Target Esterase

    11 Validation of a Rodent Model of Organophosphorus-Induced Delayed Neuropathy

    12 Intermediate Syndrome in Anticholinesterase Neurotoxicity

    Part 3 Specific Organ and Long-Term Toxicology

    13 Cardiac Effects of Anticholinesterase Agents

    14 Effects of Organophosphates on the Heart

    15 Effects of Anticholinesterases on Airway Smooth Muscle

    16 Pulmonary Toxicity of Anticholinesterases

    17 Anticholinesterase-Induced Myonecrosis

    18 Ophthalmic Toxicology of Anticholinesterases

    19 Nephrotoxicity of Anticholinesterases

    20 Immunotoxicology of Anticholinesterase Agents

    21 Immunotoxic Effects of Anticholinesterases

    22 Genotoxic and Carcinogenic Potential of Anticholinesterases

    23 Developmental and Reproductive Toxicity of Anticholinesterases

    Part 4 Environmental Aspects

    24 Agricultural and Veterinary Toxicology of Anticholinesterases

    25 Avian Toxicology of Anticholinesterases

    26 Ecotoxicological Consequences of Interactions between Avian Esterases and Organophosphorus Compounds

    27 Toxicity of Anticholinesterases to Aquatic Organisms

    Part 5 Exposure Patterns

    28 Cutaneous Absorption of Anticholinesterases

    29 Respiratory Tract Absorption of Anticholinesterases

    30 Exposure of Agricultural Workers to Anticholinesterases

    31 Greenhouse Exposure to Anticholinesterases

    32 Commercial and Residential Poisoning with Anticholinesterases

    33 Residues of Anticholinesterases in Foodstuffs

    34 Organophosphorus Compounds as Chemical Warfare Agents

    35 Combustion Toxicology of Anticholinesterases

    Part 6 Protection and Monitoring

    36 General Considerations on Workplace Safety for Anticholinesterases

    37 Physical Protection Against Anticholinesterases

    38 Screening of Agricultural Workers for Exposure to Anticholinesterases

    39 Monitoring for Exposure to Anticholinesterase-Inhibiting Organophosphorus and Carbamate Compounds by Urine Analysis

    40 Neurophysiological Monitors of Anticholinesterase Exposur

    Part 7 Clinical Toxicology by Geographical Regions

    41 Organophosphate Poisoning in the UK: The National Poisons Information Service Experience during 1984-1987

    42 Incidence, Presentation and Therapeutic Attitudes to Anticholinesterase Poisoning in the USA

    43 Incidence, Presentation and Therapeutic Attitudes to Anticholinesterase Poisoning in Asia

    44 Incidence, Presentation and Therapeutic Attitudes to Anticholinesterase Poisoning in Egypt

    45 Anticholinesterases used in the USSR: Poisoning, Treatment and Preventative Measures

    46 Acute Anticholinesterase Poisoning in China

    Part 8 Clinical and Therapeutic Aspects

    47 Clinical Presentation and Diagnosis of Acute Organophosphorus Insecticide and Carbamate Poisoning

    48 Pseudocholinesterase Deficiency and Anticholinesterase Toxicity

    49 Clinical Management of Acute Organophosphate Poisoning: an Overview

    50 Anticholinesterase Poisoning: an Overview of Pharmacotherapy

    51 Atropine in the Management of Anticholinesterase Poisoning

    52 Efficacy, Toxicity and Clinical use of Oximes in Anticholinesterase Poisoning

    53 Anticonvulsants in Anticholinesterase Poisoning

    54 Calcium Channel Blocking Agents in the Management of Acute Anticholinesterase Poisoning

    55 Acetylcholinesterase Sequestration of Organophosphate Intoxicants

    56 Prophylaxis Against Anticholinesterase Poisoning

    57 Role of Poison Control Centres in the Recognition and Management of Anticholinesterase Poisoning

    58 Forensic Aspects of Acute Anticholinesterase Poisoning

    59 Aerial Application and Spray Drift of Anticholinesterases: Protective Measures


Product details

  • No. of pages: 662
  • Language: English
  • Copyright: © Butterworth-Heinemann 1992
  • Published: March 24, 1992
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483193656

About the Authors

Bryan Ballantyne

Timothy C. Marrs

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