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Circadian Rhythms and the Human - 1st Edition - ISBN: 9780723605928, 9781483193427

Circadian Rhythms and the Human

1st Edition

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Authors: D. S. Minors J. M. Waterhouse
eBook ISBN: 9781483193427
Imprint: Butterworth-Heinemann
Published Date: 24th September 1981
Page Count: 348
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Circadian Rhythms and the Human covers the basic principles behind the human circadian rhythms. This book is composed of 12 chapters that discuss the detection, analysis, and definition of rhythms, specifically exogenous and endogenous rhythms. This book also demonstrates the mechanism of metabolic and gastrointestinal rhythms. The opening chapters deal with the rhythms in living organism; establishing the endogeneity of rhythms; definition of nychthemeral rhythm; methods of measuring the frequency of rhythms; exogenous effects upon the temperature rhythm; interaction between exogenous and endogenous influences; and possible origins of renal rhythmicity. The succeeding chapters consider the effect of exercise at different times of day and the concept of sleep-wakefulness rhythm. The discussion then shifts to the effects of repeated time-zone transitions and the effects of time on drug administration. The closing chapters are devoted to the assessment of work performance during shift work.
The book can provide useful information to doctors, students, researchers, and the general reader.

Table of Contents


Chapter 1 Introduction and Methods of Study

Rhythms in Living Organisms

Definition of Terms

Detection of Rhythms

Analysis of Rhythms

Exogenous and Endogenous Rhythms

Establishing the Endogeneity of Rhythms;


Chapter 2 The Circadian Rhythm of Deep Body Temperature

Methods of Measurement

The Nychthemeral Rhythm

The Endogenous Component

Exogenous Effects upon the Temperature Rhythm

The Interaction between Exogenous and Endogenous Influences

Origin of the Rhythm

Implications and Usefulness

Chapter 3 Cardiovascular, Respiratory, Metabolic and Gastrointestinal Rhythms

I Cardiovascular system: Continuous Monitoring

Blood Pressure

Pulse Rate

Other Cardiovascular Variables

The Causal Nexus between Cardiovascular Variables

II Respiratory System: Oxygen Consumption, Respiratory Frequency and Blood Gas Partial Pressures

Mechanical Factors

The Effect of Exercise at Different Times of Day

The Causal Nexus

III Metabolic and Gastrointestinal Rhythms: Metabolic Rhythms

Gastrointestinal Rhythms

Chapter 4 The Kidney and Hormones Affecting it Endogenous and Exogenous Components

Possible Origins of Renal Rhythmicity

Chapter 5 Sleep and Wakefulness

Studying the Sleep-Wakefulness Rhythm

Results of Sleep-Wake Fullness Studies

Inferences from Isolation Experiments

Sleep Stages

Chapter 6 Rhythms in Mental Performance

Problems Associated with Psychometric Testing

Assessment of Mental Performance Rhythms Results on a Nychthemeral Routine

The Causal Nexus and Performance Rhythms


Chapter 7 The Endocrine System


Cortisol, Adrenocorticotrophic Hormone and Corticotrophin Releasing Factor

Growth Hormone

Other Hormones

Some General Problems

Chapter 8 Rhythms in the Infant and the Aged

I The Infant: Results

Inferences and Speculations

II The Aged

Chapter 9 Time-Zone Transitions



Differences Produced by Time-Zone Transitions

Entrainment by Partition: Masking

Consequences of Repeated Time-Zone Transitions

Advice to Travelers

Chapter 10 Shiftwork


Some Problems in Assessing Implications of Shift Work

Complaints Associated with Shift Work

Performance during Shift Work

Results and Problems with Other Shift Systems

Permanent Shift Workers and Adaptability to Shift Work


Chapter 11 Clinical Implications

Normal Values and Circadian Rhythms


Changed Circadian Rhythms in Illness

The Effects of Time of Drug Administration—Chronotherapy

Implications for the Availability of Medical Services


Chapter 12 Circadian Rhythm Mechanisms

A Hierarchy of Rhythms and the Causal Nexus between Them

How Many Clocks?

Properties of the Endogenous Oscillator(s)

Entrainment and Zeitgeber

Zeitgeber in Man

Appendix Statistical Analysis of Rhythms




No. of pages:
© Butterworth-Heinemann 1981
24th September 1981
eBook ISBN:

About the Authors

D. S. Minors

J. M. Waterhouse

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