Ciliary Function in Mammalian Development

Ciliary Function in Mammalian Development

1st Edition - December 11, 2008

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  • Editor: Bradley Yoder
  • Hardcover ISBN: 9780123744531
  • eBook ISBN: 9780080922478

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Cilia--the tiny hairlike structures on the surface of cells—-have recently been identified as playing a role in a variety of disease and developmental disorders. Absent or defective cilia in certain cells can cause infertility, blindness, kidney disease, and lung disease. This volume presents recent findings in cilia research and current thought on the role of cilia in disease and developmental abnormalities.


Researchers in cell, developmental, and molecular biology as well as researchers in genetics

Table of Contents

  • 1. Assembly and function of the basal body
    Susan Dutcher
    2. Cilia assembly and maintenance
    Lotte Pedersen and Joel Rosenbaum
    3. Origin and Evolution of the cilium
    Peter Satir, David R. Mitchell, and Gaspar Jekely
    4. Transport and targeting of ciliary proteins
    Gregory Pazour and Robert Bloodgood
    5. Tubulin Modifications and Regulation of Cilia formation and function
    Jacek Gaertig
    6. Ciliary functions in early embryo patterning and axis formation
    Martina Brueckner
    7. Cilia mediated control of Wnt signaling activity
    Nicholas Katsanis
    8. Ciliary function in regulating planar cell polarity of the inner ear
    Ping Chen
    9. Ciliary role in hedgehog signaling activity
    Jeremy Reiter
    10. Cilia regulation of cell migration during development and tissue repair
    Soren Christensen
    11. Cilia involvement in patterning and maintenance of bone
    Rosa Serra and Courtney Haycraft
    12. IFT in photoreceptor assembly and function
    Joe Besharse
    13. Ciliary dysfunction disease
    Neeraj Sharma and Bradley Yoder

Product details

  • No. of pages: 488
  • Language: English
  • Copyright: © Academic Press 2008
  • Published: December 11, 2008
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123744531
  • eBook ISBN: 9780080922478

About the Editor

Bradley Yoder

Affiliations and Expertise

University of Alabama, Birmingham, USA

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