Description

This special volume of Progress in Molecular Biology and Translational Science focuses on chronobiology.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Readership

Researchers in molecular biology and translational science

Table of Contents

Contributors

Introduction to Biological Timing in Health and Disease

References

Chapter One. The Suprachiasmatic Nucleus and the Circadian Timing System

1 Introduction

2 The Emergence of a Circadian Neurobiology

3 Anatomical Organization of the SCN

4 Afferent and Efferent Connections

5 Conclusions

6 Reprise

References

Chapter Two. Epigenetic Regulation of the Molecular Clockwork

1 Introduction to Epigenetics and the Circadian Clock

2 Circadian Epigenetics and Synaptic Plasticity in the Brain

3 Linking the Circadian Metabolome and Metabolism to Epigenetics

4 Conclusions

References

Chapter Three. Diversity of Human Clock Genotypes and Consequences

1 Introduction

2 BMAL1

3 Clock

4 NPAS2

5 PER1

6 PER2

7 PER3

8 CRY1

9 CRY2

10 REV-ERBα

11 CK1ε

12 CK1δ

13 CUL1

14 β-TrCP

15 DEC1

16 DEC2

17 TIMELESS

18 Concluding Remarks

References

Chapter Four. Peripheral Circadian Oscillators: Time and Food

1 Introduction

2 The SCN as Master Clock

3 The Peripheral Oscillators and Their Relationship with Clock Genes

4 The SCN as the Driving Force Behind the Oscillators

5 Synchronization of the Circadian System by the SCN

6 Timing by Food?

7 Energy Oscillation in the Cell

8 Heme as Another Metabolic Clock Connection Possibility

9 The Link Between Clock Genes and Metabolic Genes

10 Conclusions

Acknowledgments

References

Chapter Five. Circadian Clocks, Food Intake, and Metabolism

1 Introduction

2 Physiology

3 Pathology

4 Chronotherapeutics

5 Conclusion

Acknowledgments

References

Chapter Six. Control of Sleep and Wak

Details

No. of pages:
376
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
Electronic ISBN:
9780123972804
Print ISBN:
9780123969712

About the serial-volume-editor

Reviews

Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal