Chronobiology: Biological Timing in Health and Disease

Chronobiology: Biological Timing in Health and Disease

1st Edition - July 27, 2013

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  • Editor: Martha Gillette
  • eBook ISBN: 9780123972804
  • Hardcover ISBN: 9780123969712

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This special volume of Progress in Molecular Biology and Translational Science focuses on chronobiology.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Researchers in molecular biology and translational science

Table of Contents

  • Contributors

    Introduction to Biological Timing in Health and Disease


    Chapter One. The Suprachiasmatic Nucleus and the Circadian Timing System

    1 Introduction

    2 The Emergence of a Circadian Neurobiology

    3 Anatomical Organization of the SCN

    4 Afferent and Efferent Connections

    5 Conclusions

    6 Reprise


    Chapter Two. Epigenetic Regulation of the Molecular Clockwork

    1 Introduction to Epigenetics and the Circadian Clock

    2 Circadian Epigenetics and Synaptic Plasticity in the Brain

    3 Linking the Circadian Metabolome and Metabolism to Epigenetics

    4 Conclusions


    Chapter Three. Diversity of Human Clock Genotypes and Consequences

    1 Introduction

    2 BMAL1

    3 Clock

    4 NPAS2

    5 PER1

    6 PER2

    7 PER3

    8 CRY1

    9 CRY2

    10 REV-ERBα

    11 CK1ε

    12 CK1δ

    13 CUL1

    14 β-TrCP

    15 DEC1

    16 DEC2


    18 Concluding Remarks


    Chapter Four. Peripheral Circadian Oscillators: Time and Food

    1 Introduction

    2 The SCN as Master Clock

    3 The Peripheral Oscillators and Their Relationship with Clock Genes

    4 The SCN as the Driving Force Behind the Oscillators

    5 Synchronization of the Circadian System by the SCN

    6 Timing by Food?

    7 Energy Oscillation in the Cell

    8 Heme as Another Metabolic Clock Connection Possibility

    9 The Link Between Clock Genes and Metabolic Genes

    10 Conclusions



    Chapter Five. Circadian Clocks, Food Intake, and Metabolism

    1 Introduction

    2 Physiology

    3 Pathology

    4 Chronotherapeutics

    5 Conclusion



    Chapter Six. Control of Sleep and Wakefulness in Health and Disease

    1 The Brain Stem

    2 The Hypothalamus

    3 The Cortex

    4 The Endocrine System

    5 The Rest


    Chapter Seven. Circadian Rhythms, Sleep Deprivation, and Human Performance

    1 Introduction

    2 Sleep–Wake and Circadian Regulation: Two-Process Model

    3 Circadian Rhythms of Performance

    4 Protocols to Assess Circadian Variation in Neurobehavioral Functions

    5 Interindividual Variability in Circadian Rhythms

    6 Sleep Deprivation and Performance

    7 Conclusions



    Chapter Eight. Timing, Sleep, and Respiration in Health and Disease

    1 Introduction

    2 Normal Breathing

    3 Circadian Rhythms and Breathing

    4 Sleep and Breathing

    5 Implications for Human Disease

    6 Conclusions


    Chapter Nine. The Circadian Clock in Cancer Development and Therapy

    1 Introduction

    2 Circadian Dysfunction Promotes Cancer Development in Humans

    3 Circadian Disruption Promotes Cancer Development in Animal Models

    4 The Role of the Mammalian Circadian Clock in Tumor Suppression

    5 Anticancer Chronotherapy

    6 Conclusions



    Chapter Ten. Health Consequences of Circadian Disruption in Humans and Animal Models

    1 Introduction

    2 Circadian Regulation

    3 Types of Circadian Disruption in Humans and Animal Models

    4 Health Consequences of Circadian Disruption

    5 Future Research Questions


    Chapter Eleven. Sleep and Circadian Rhythm Disruption in Social Jetlag and Mental Illness

    1 The Biology of Sleep

    2 Sleep and Circadian Rhythm Disruption Arising from Social Timing

    3 SCRD and Psychoses

    4 A Conceptual Framework for SCRD in Psychiatric Illness

    5 Conclusions



Product details

  • No. of pages: 376
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: July 27, 2013
  • Imprint: Academic Press
  • eBook ISBN: 9780123972804
  • Hardcover ISBN: 9780123969712

About the Serial Volume Editor

Martha Gillette

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