Chronic Renal Disease

2nd Edition - August 28, 2019
Editors: Paul L. Kimmel, Mark E. Rosenberg
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 1 5 8 7 6 - 0
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 5 8 7 7 - 7

Chronic Renal Disease, Second Edition, comprehensively investigates the physiology, pathophysiology, treatment and management of chronic kidney disease (CKD). This translati… Read more

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Chronic Renal Disease, Second Edition, comprehensively investigates the physiology, pathophysiology, treatment and management of chronic kidney disease (CKD). This translational reference takes an in-depth look at CKD with no coverage of dialysis or transplantation. Chapters are devoted to the scientific investigation of chronic kidney disease, the most common problems faced by nephrologists in the management of chronic kidney disease, specific illnesses in the CKD framework, and how the management of CKD in a polycystic kidney disease patient differs from other CKD patients. This award-winning reference features a series of case studies, covering both clinical aspects and pathophysiology.

Questions are open ended, progressively more difficult, and repetitive across different patient clinical problems and different chapters. The cases and questions included will be useful for medical students, residency board reviews, and clinician teaching or conference preparation.

I INTRODUCTION

1. Introduction

II CLASSIFICATION AND MEASUREMENT

2. From Bright’s Disease to Chronic Kidney Disease

3. Classification of Chronic Kidney Disease - Historic Perspective: From Insufficiency and Failure to Chronic Kidney Disease

4. Assessing Kidney Function

5. Clinical Assessment and Management of Chronic Kidney Disease Across Its Stages

III EPIDEMIOLOGY

6. Epidemiology of Chronic Kidney Disease - Scope of the Problem

7. Gender Issues in Chronic Kidney Disease

8. Ethnicity and Chronic Kidney Disease - United States

9. Ethnicity and Chronic Kidney Disease in Disadvantaged Populations - An International Perspective

10. Ethnicity and Chronic Kidney Disease in Japan

11. Ethnicity and Chronic Kidney Disease in Africa

12. Ethnicity and Chronic Kidney Disease in China

13. Poverty and Chronic Kidney Disease

IV PATHOPHYSIOLOGY

14. The Uremic Syndrome

15. Pathophysiology of Proteinuria: Albuminuria as a Target for Treatment

16. Protein Energy Metabolism in Chronic Kidney Disease

17. Aging and the Kidney: Clinical and Pathophysiologic Issues

18. Pathophysiology of Chronic Kidney Disease Progression: Organ and Cellular Considerations

19. Pathophysiology of Diabetic Nephropathy

20. Prenatal Antecedents of Chronic Kidney Disease

21. Pathophysiology of Hypertension in Chronic Kidney Disease

22. Chronic Kidney Disease and the Vascular Endothelium

23. Cardiovascular Disease and Chronic Kidney Disease

24. Inflammation in Chronic Kidney Disease

25. Genetics and Chronic Kidney Disease

26. Acute Kidney Injury and Chronic Kidney Disease

V COMPLICATIONS OF CHRONIC KIDNEY DISEASE

27. Psychosocial Issues in Chronic Kidney Disease Patients

28. Ophthalmic Issues in Chronic Kidney Disease

29. Neurologic Complications of Chronic Kidney Disease

30. Hematologic Complications of Chronic Kidney Disease - Anemia and Platelet Disorders

31. Hematologic and Infectious Complications of Chronic Kidney Disease

32. Immune Function in Chronic Kidney Disease

33. Chronic Kidney Disease and Gastrointestinal Disorders

34. Endocrine Complications of Chronic Kidney Disease

35. Chronic Kidney Disease - Mineral and Bone Disorders

36. Sleep Disorders in Chronic Kidney Disease

37. Sexual Dysfunction in Chronic Kidney Disease

VI FLUID AND ELECTROLYTE DISORDERS IN CHRONIC KIDNEY DISEASE

38. Water Homeostasis in Chronic Kidney Disease

39. Sodium Metabolism in Chronic Kidney Disease

40. Potassium Metabolism in Chronic Kidney Disease

41. Calcium, Phosphate, and Magnesium Metabolism in Chronic Kidney Disease

42. Acid/Base Metabolism in Chronic Kidney Disease

43. Uric Acid Metabolism and the Kidney

44. Trace Elements in Chronic Kidney Disease

VII CHRONIC KIDNEY DISEASE AND SYSTEMIC ILLNESSES - CLINICAL CONSIDERATIONS

45. Approach to the Patient with Chronic Glomerular Disease

46. Approach to the Patient with Hypertensive Nephrosclerosis

47. Approach to the Patient with Chronic Kidney Disease and Renovascular Disease

48. Polycystic Kidney Disease

49. Lupus Nephritis

50. Sickle Cell Disease

51. Approach to Chronic Kidney Disease in the Diabetic Patient

52. Human Immunodeficiency Virus Infection and Chronic Kidney Disease

53. Liver Disease and Chronic Kidney Disease

54. Chronic Kidney Disease and Heart Failure - A Nephrologic Approach

55. Cancer and Chronic Kidney Disease

VIII THERAPEUTIC CONSIDERATIONS

56. The Interdisciplinary Clinic for Chronic Kidney Disease

57. Slowing Progression of Chronic Kidney Disease

58. Approach to the Patient with Non-nephrotic Proteinuria

59. Nutritional Management of Patients with Chronic Kidney Disease

60. Management of Anemia in Chronic Kidney Disease

61. Management of Hypertension in Chronic Kidney Disease

62. Management of Mineral and Bone Disorders in Chronic Kidney Disease

63. Drug Metabolism in Chronic Kidney Disease

64. Use of Diuretics in Chronic Kidney Disease Patients

65. Nonsteroidal Anti-inflammatory Drugs and Opioids in Chronic Kidney

66. Dyslipidemia and Chronic Kidney Disease

67. Nephrolithiasis, Nephrocalcinosis, and Hypercalciuria

68. Treatment of Psychiatric Disorders in Chronic Kidney Disease Patients

69. Preparing for Transplantation

70. Preparing for Hemodialysis

71. Preparing for Peritoneal Dialysis

IX SPECIAL CONSIDERATIONS

72. Emerging Therapies

73. The Renal Biopsy in Chronic Kidney

74. Pregnancy and Kidney Disease

75. Chronic Kidney Disease in Children

76. Reflux Nephropathy

77. Chronic Kidney Disease in the Elderly - Who Has It? Who Does One Treat? and How are They to be Treated?

78. Pain and Chronic Kidney Disease

79. The Perioperative Management of the Patient with Chronic Kidney Disease

80. Ethical Issues in Chronic Kidney Disease Patients

81. Imaging the Chronic Kidney Disease Patient

Paul L. Kimmel

Paul L. Kimmel, MD, MACP, FRCP, FASN, was educated at Yale College and the New York University School of Medicine. He completed his internal medicine residency at Bellevue Hospital in New York City and Nephrology fellowship at the Hospital of the University of Pennsylvania. He was a member of the faculty at the University of Pennsylvania and the George Washington University, where he attained the rank of professor. From 2001 to 2006, Dr. Kimmel served as Director of the Division of Renal Diseases and Hypertension at George Washington University. From 2006 to 2008, he was the Director of Education of the American Society of Nephrology. Dr. Kimmel currently is Clinical Professor of Medicine at George Washington University in Washington, DC. His interests include psychosocial adaptation to chronic renal disease, sleep disorders in patients with kidney disease, zinc metabolism in renal diseases, HIV associated kidney diseases, the clinical genetics of common kidney disease, and the interrelationships between acute kidney injury and chronic kidney disease.

Affiliations and expertise

Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University, Washington, DC, United States

Mark E. Rosenberg

Mark E. Rosenberg, MD, FASN, attended medical school at the University of Manitoba in Winnipeg, Canada, and did his internal medicine residency and nephrology fellowship at the University of Minnesota. He served as Director of the Division of Renal Diseases and Hypertension at the university from 2000 to 2009. From 2009 to 2012, he was the Chief of Medicine and Director of the Primary and Specialty Medicine Service Line at the Minneapolis VA Health Care System. Dr. Rosenberg currently serves as Vice Dean for Education and Academic Affairs, and Professor of Medicine at the University of Minnesota Medical School in Minneapolis, Minnesota. In this position, he is responsible for the continuum of medical education. He served as Chair of the Postgraduate Education Committee and Education Director for Kidney Week for 6 years before being elected in 2013 to the Council of the American Society of Nephrology. Dr. Rosenberg served as President of the American Society of Nephrology in 2019. His interests include pathophysiology and progression of chronic kidney disease, kidney regeneration following acute injury, models of care delivery including telehealth, and workforce issues in nephrology.

Affiliations and expertise

Professor of Medicine, Division of Renal Diseases and Hypertension; Vice Dean for Education, University of Minnesota Medical School, Minneapolis, Minnesota