Chromatin Signaling and Neurological Disorders

Chromatin Signaling and Neurological Disorders

1st Edition - May 24, 2019

Write a review

  • Editor: Olivier Binda
  • eBook ISBN: 9780128137970
  • Hardcover ISBN: 9780128137963

Purchase options

Purchase options
DRM-free (Mobi, EPub, PDF)
Available
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

Chromatin Signaling and Neurological Disorders, Volume Seven, explores our current understanding of how chromatin signaling regulates access to genetic information, and how their aberrant regulation can contribute to neurological disorders. Researchers, students and clinicians will not only gain a strong grounding on the relationship between chromatin signaling and neurological disorders, but they'll also discover approaches to better interpret and employ new diagnostic studies and epigenetic-based therapies. A diverse range of chapters from international experts speaks to the basis of chromatin and epigenetic signaling pathways and specific chromatin signaling factors that regulate a range of diseases. In addition to the basic science of chromatin signaling factors, each disease-specific chapter speaks to the translational or clinical significance of recent findings, along with important implications for the development of epigenetics-based therapeutics. Common themes of translational significance are also identified across disease types, as well as the future potential of chromatin signaling research.

Key Features

  • Examines specific chromatin signaling factors that regulate spinal muscular atrophy, ulbospinal muscular atrophy, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, multiple sclerosis, Angelman syndrome, Rader-Willi syndrome, and more
  • Contains chapter contributions from international experts who speak to the clinical significance of recent findings and the implications for the development of epigenetics-based therapeutics
  • Provides researchers, students and clinicians with approaches to better interpret and employ new diagnostic studies for treating neurological disorders

Readership

Translational researchers, clinicians and graduate students in genomic medicine, epigenetics, neurology, neuroscience, and neuropsychiatry interested in genetics and the epigenetic basis of neurological disorders; life science researchers; developmental biologists; neurologists, psychiatrists, and other MD/clinicians; pharmacologists in industry and academia

Table of Contents

  • Background

    Preface

    1. Chromatin and epigenetic signaling pathways

    2. Non-pathologic neurological development

    Neurodegenerative disorders

    3. Spinal muscular atrophy

    4. Triplet-Repeat Neurological Diseases

    5. Amyotrophic Lateral Sclerosis

    6. Charcot-Marie-Tooth disease

    7. Parkinson's disease

    8. Huntington's disease

    9. Multiple Sclerosis

    10. Ataxia Telangiectasia

    11. Cockayne Syndrome neurodevelopmental disorders

    Neurodevelopmental disorders

    12. Angelman Syndrome and Prader-Willi Syndrome

    13. Rett Syndrome

    14. Rubinstein-Taybi Syndrome

    15. Sotos Syndrome

    16. ATRX

    17. Fragile X syndrome and mental retardation

    Neuropsychiatric disorders

    18. Autism Spectrum Disorder and Asperger Syndrome

    19. Schizophrenia

    20. Gilles de la Tourette Syndrome

    21. Alzheimer's disease (and other dementias)

    22. Mood disorders

    23. Attention deficit hyperactivity disorder (ADHD)

    24. Obsessive compulsive disorder (OCD)

Product details

  • No. of pages: 378
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: May 24, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128137970
  • Hardcover ISBN: 9780128137963

About the Series Volume Editor

Olivier Binda

Dr. Olivier Binda is a Principal Investigator at Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, England, specializing in epigenetics and gene expression as it relates to human disease. Dr. Binda co-edited Chromatin Signaling and Diseases (Elsevier 2016), a volume in Elsevier’s Translational Epigenetics series, and has published 20 scientific papers in such peer reviewed journals as the Journal of Biological Chemistry, Biochemistry, Epigenetics, Oncogene, Scientific Reports, and Stem Cell Research. In past positions he has served as a postdoctoral fellow at McGill University and Stanford University, and he completed his PhD in Biochemistry at McGill University in 2007.

Affiliations and Expertise

Principal Investigator, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK

Ratings and Reviews

Write a review

There are currently no reviews for "Chromatin Signaling and Neurological Disorders"