Chondroitin Sulfate
Structure, Role and Pharmacological Activity
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CS is an unbranched, polydisperse, complex glycosaminoglycan extracted and purified from various tissues. This polyanion is interacting with both plasma and cells, it is able to modulate many biochemical and physiologic processes. Due to the presence of sulfate groups in different amounts and located in various positions, CS represents a very heterogeneous family of polysaccharides. therefore, the preparative approach and the analytical techniques are of paramount importance to produce CS with specific structure and properties and of pharmaceutical grade.
Key Features
*Includes recent technologies and methodologies to study and understand the structure and properties of chondroitin sulfate (CS)
*Authoritative contributors from the scientific community with expertise in the field of CS and complex polysaccharides
*Detailed and accurate figures to describe and illustrate complex molecular and macromolecular structures and properties
*Authoritative contributors from the scientific community with expertise in the field of CS and complex polysaccharides
*Detailed and accurate figures to describe and illustrate complex molecular and macromolecular structures and properties
Readership
University researchers and students in the field of complex polysaccharides, biomaterials, biochemistry, pharmacology and pathology. Pharmaceutical companies, researchers, and medical doctors/clinicians.
Table of Contents
- STRUCTURE
Isolation, purification and analysis of chondroitin sulfate proteoglycans
Fumiko Matsui and Atsuhiko Oohira
Isolation and Purification of Chondroitin Sulfate
Luiz-Claudio F. Silva
Structure of chondroitin sulfate
Fotini N. Lamari and Nikos K. Karamanos
Progress in the structural biology of chondroitin sulfate
Barbara Mulloy
The biosynthesis and catabolism of galactosaminoglycans
Vikas Prabhakar and Ram Sasisekharan
Biosynthesis of chondroitin sulfate: from the early, precursor discoveries to nowadays, genetic approaches
Mauro S.G. Pavao, Ana Christina Vilela-Silva and Paulo A.S. Mourao
Advances in the analysis of chondroitin/dermatan sulfate
M. Stylianou, I.-E. Triantaphyllidou and D.H. Vynios
Chondroitin sulfate lyases - their applications in analysis and glycobiotechnology
Emmanuel Petit, Cedric Delattre, Dulce Papy-Garcia and Phillipe Michaud
Chondroitin sulfate Lyases: Structure, Activity and Applications in Analysis and the Treatment of Diseases
Robert J. Linhardt, Fikri Y Avci, Toshohiko Toida, Yeong Shik Kim and Miroslaw Cygler
BIOLOGICAL ROLE OF CHONDROITIN SULFATE
Structure, metabolism and tissue roles of chondroitin sulfate proteoglycans
Christopher J. Handley, Tom Samiric and Mina Z. Ilic
Emergence and structural characteristics of chondroitin sulfates in the animal kingdom
Lucia O. Sampaio and Helena B. Nader
Role of the sulfation pattern of chondroitin sulfate in its biological activities and the binding of growth factors
Chilkunda D. Nandini and Kazuyuki Sugahara
Chondroitin sulfate as a key molecule in the development of atherosclerosis and cancer progression
A.D. Theocharis, G.N. Tzanakakis and N.K. Karamanos
Chondroitin sulfate proteoglycans in tumor progression
Yanusz Wegrowski and Francois-Xavier Maquart
Chondroitin sulfate proteoglycans in the brain
Sachiko Aono and Atsuhiko Oohira
Chondroitin/dermatan sulfate in the central nervous system: structures and functions in health and disease
Uwe Rauch and Joachim Kappler
Chondroitin sulfate proteoglycan and its degradation products in CNS repair
Asya Rolls and Michal Schwartz
Role of Chondroitin 4-Sulfate in Pregnancy-Associated Malaria
D. Channe Gowda
PHARMACOLOGICAL ACTIVITIES OF CHONDROITIN SULFATE
Immunological activity of chondroitin sulfate
Toshihiko Toida, Shinobu Sakai, Hiroshi Akiyama and Robert J. Lindhardt
Antioxidant activity of chondroitin sulfate
G.M. Campo, A. Avenoso, S. Campo, A.M. Ferlazzo and A. Caltroni
Effects of chondroitin sulfate on the cellular metabolism
N. Brandl, J. Holzmann, R. Schabus and M. Huettinger
In vitro effects of chondroitin sulfate
A. Fioravanti, R. Marcolongo and G. Collodel
Effect of chondroitin sulfate as nutraceutical in dogs with arthropathies
Britta Dobenecker
Chondroitin sulfate as a structure modifying agent
Daniel Uebelhart, Ruud Knols, Elling D. de Bruin and Gust Verbruggen
CLINICAL EFFICACY AND TRIALS
Chondroitin sulfate in the management of erosive osteoarthritis of the interphalangeal finger joints
Gust Verbruggen
Chondroitin sulfate in the management of hip and knee osteoarthritis: an overview
Geraldine Bana, Benedicte Jamard, Evelyne Verrouil and Bernard Mazieres
Treatment of knee osteoarthritis with oral chondroitin sulfate
Daniel Uebelhart, Ruud Knols, Elling D. de Bruin and Gust Verbruggen
Product details
- No. of pages: 600
- Language: English
- Copyright: © Academic Press 2006
- Published: June 28, 2006
- Imprint: Academic Press
- eBook ISBN: 9780080471952
About the Serial Volume Editor
Nicola Volpi
Affiliations and Expertise
University of Modena and Reggio Emilia, Department of Biologia Animale, Modena, Italy