Chondroitin Sulfate

Chondroitin Sulfate

Structure, Role and Pharmacological Activity

1st Edition - June 28, 2006

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  • Editor: Nicola Volpi
  • eBook ISBN: 9780080471952

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Description

CS is an unbranched, polydisperse, complex glycosaminoglycan extracted and purified from various tissues. This polyanion is interacting with both plasma and cells, it is able to modulate many biochemical and physiologic processes. Due to the presence of sulfate groups in different amounts and located in various positions, CS represents a very heterogeneous family of polysaccharides. therefore, the preparative approach and the analytical techniques are of paramount importance to produce CS with specific structure and properties and of pharmaceutical grade.

Key Features

*Includes recent technologies and methodologies to study and understand the structure and properties of chondroitin sulfate (CS)
*Authoritative contributors from the scientific community with expertise in the field of CS and complex polysaccharides
*Detailed and accurate figures to describe and illustrate complex molecular and macromolecular structures and properties

Readership

University researchers and students in the field of complex polysaccharides, biomaterials, biochemistry, pharmacology and pathology. Pharmaceutical companies, researchers, and medical doctors/clinicians.

Table of Contents

  • STRUCTURE

    Isolation, purification and analysis of chondroitin sulfate proteoglycans
    Fumiko Matsui and Atsuhiko Oohira

    Isolation and Purification of Chondroitin Sulfate
    Luiz-Claudio F. Silva

    Structure of chondroitin sulfate
    Fotini N. Lamari and Nikos K. Karamanos

    Progress in the structural biology of chondroitin sulfate
    Barbara Mulloy

    The biosynthesis and catabolism of galactosaminoglycans
    Vikas Prabhakar and Ram Sasisekharan

    Biosynthesis of chondroitin sulfate: from the early, precursor discoveries to nowadays, genetic approaches
    Mauro S.G. Pavao, Ana Christina Vilela-Silva and Paulo A.S. Mourao

    Advances in the analysis of chondroitin/dermatan sulfate
    M. Stylianou, I.-E. Triantaphyllidou and D.H. Vynios

    Chondroitin sulfate lyases - their applications in analysis and glycobiotechnology
    Emmanuel Petit, Cedric Delattre, Dulce Papy-Garcia and Phillipe Michaud

    Chondroitin sulfate Lyases: Structure, Activity and Applications in Analysis and the Treatment of Diseases
    Robert J. Linhardt, Fikri Y Avci, Toshohiko Toida, Yeong Shik Kim and Miroslaw Cygler


    BIOLOGICAL ROLE OF CHONDROITIN SULFATE

    Structure, metabolism and tissue roles of chondroitin sulfate proteoglycans
    Christopher J. Handley, Tom Samiric and Mina Z. Ilic

    Emergence and structural characteristics of chondroitin sulfates in the animal kingdom
    Lucia O. Sampaio and Helena B. Nader

    Role of the sulfation pattern of chondroitin sulfate in its biological activities and the binding of growth factors
    Chilkunda D. Nandini and Kazuyuki Sugahara

    Chondroitin sulfate as a key molecule in the development of atherosclerosis and cancer progression
    A.D. Theocharis, G.N. Tzanakakis and N.K. Karamanos

    Chondroitin sulfate proteoglycans in tumor progression
    Yanusz Wegrowski and Francois-Xavier Maquart

    Chondroitin sulfate proteoglycans in the brain
    Sachiko Aono and Atsuhiko Oohira

    Chondroitin/dermatan sulfate in the central nervous system: structures and functions in health and disease
    Uwe Rauch and Joachim Kappler

    Chondroitin sulfate proteoglycan and its degradation products in CNS repair
    Asya Rolls and Michal Schwartz

    Role of Chondroitin 4-Sulfate in Pregnancy-Associated Malaria
    D. Channe Gowda


    PHARMACOLOGICAL ACTIVITIES OF CHONDROITIN SULFATE

    Immunological activity of chondroitin sulfate
    Toshihiko Toida, Shinobu Sakai, Hiroshi Akiyama and Robert J. Lindhardt

    Antioxidant activity of chondroitin sulfate
    G.M. Campo, A. Avenoso, S. Campo, A.M. Ferlazzo and A. Caltroni

    Effects of chondroitin sulfate on the cellular metabolism
    N. Brandl, J. Holzmann, R. Schabus and M. Huettinger

    In vitro effects of chondroitin sulfate
    A. Fioravanti, R. Marcolongo and G. Collodel

    Effect of chondroitin sulfate as nutraceutical in dogs with arthropathies
    Britta Dobenecker

    Chondroitin sulfate as a structure modifying agent
    Daniel Uebelhart, Ruud Knols, Elling D. de Bruin and Gust Verbruggen


    CLINICAL EFFICACY AND TRIALS

    Chondroitin sulfate in the management of erosive osteoarthritis of the interphalangeal finger joints
    Gust Verbruggen

    Chondroitin sulfate in the management of hip and knee osteoarthritis: an overview
    Geraldine Bana, Benedicte Jamard, Evelyne Verrouil and Bernard Mazieres

    Treatment of knee osteoarthritis with oral chondroitin sulfate
    Daniel Uebelhart, Ruud Knols, Elling D. de Bruin and Gust Verbruggen

Product details

  • No. of pages: 600
  • Language: English
  • Copyright: © Academic Press 2006
  • Published: June 28, 2006
  • Imprint: Academic Press
  • eBook ISBN: 9780080471952

About the Serial Volume Editor

Nicola Volpi

Affiliations and Expertise

University of Modena and Reggio Emilia, Department of Biologia Animale, Modena, Italy

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