CS is an unbranched, polydisperse, complex glycosaminoglycan extracted and purified from various tissues. This polyanion is interacting with both plasma and cells, it is able to modulate many biochemical and physiologic processes. Due to the presence of sulfate groups in different amounts and located in various positions, CS represents a very heterogeneous family of polysaccharides. therefore, the preparative approach and the analytical techniques are of paramount importance to produce CS with specific structure and properties and of pharmaceutical grade.

Key Features

*Includes recent technologies and methodologies to study and understand the structure and properties of chondroitin sulfate (CS) *Authoritative contributors from the scientific community with expertise in the field of CS and complex polysaccharides *Detailed and accurate figures to describe and illustrate complex molecular and macromolecular structures and properties


University researchers and students in the field of complex polysaccharides, biomaterials, biochemistry, pharmacology and pathology. Pharmaceutical companies, researchers, and medical doctors/clinicians.

Table of Contents

STRUCTURE Isolation, purification and analysis of chondroitin sulfate proteoglycans Fumiko Matsui and Atsuhiko Oohira Isolation and Purification of Chondroitin Sulfate Luiz-Claudio F. Silva Structure of chondroitin sulfate Fotini N. Lamari and Nikos K. Karamanos Progress in the structural biology of chondroitin sulfate Barbara Mulloy The biosynthesis and catabolism of galactosaminoglycans Vikas Prabhakar and Ram Sasisekharan Biosynthesis of chondroitin sulfate: from the early, precursor discoveries to nowadays, genetic approaches Mauro S.G. Pavao, Ana Christina Vilela-Silva and Paulo A.S. Mourao Advances in the analysis of chondroitin/dermatan sulfate M. Stylianou, I.-E. Triantaphyllidou and D.H. Vynios Chondroitin sulfate lyases - their applications in analysis and glycobiotechnology Emmanuel Petit, Cedric Delattre, Dulce Papy-Garcia and Phillipe Michaud Chondroitin sulfate Lyases: Structure, Activity and Applications in Analysis and the Treatment of Diseases Robert J. Linhardt, Fikri Y Avci, Toshohiko Toida, Yeong Shik Kim and Miroslaw Cygler BIOLOGICAL ROLE OF CHONDROITIN SULFATE Structure, metabolism and tissue roles of chondroitin sulfate proteoglycans Christopher J. Handley, Tom Samiric and Mina Z. Ilic Emergence and structural characteristics of chondroitin sulfates in the animal kingdom Lucia O. Sampaio and Helena B. Nader Role of the sulfation pattern of chondroitin sulfate in its biological activities and the binding of growth factors Chilkund


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© 2006
Academic Press
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